hrp0084p1-24 | Diabetes | ESPE2015

The Influence of miR-125b in Pancreatic β-Cell Apoptosis

Han Bei , Zhu Ziyang , Gu Wei , Ni Shining , Yang Ruixue , Shi Xing , Yuan Xuewen , Gao Wentao

Background: Type 1 diabetes is characterised by destruction of islet β cell by autoimmune insulitis and islet cell apoptosis. This study analysed the microRNA 125b how to regulate pancreatic β-cells dysfunction, aiming to elucidate the association between miRNA125b and type 1 diabetes.Objective and hypotheses: Recent study indicate miRNA may have role in the development of type 1 diabetes, so this study analyse the miRNA expression profile in t...

hrp0084p3-1050 | Growth | ESPE2015

BMI and Total Cholesterol are Negative Predictors of Peak Stimulated GH in Han Children with Short Stature

Wu Su , Gu Wei , Zhu Ziyang , Ni Shining , Shi Xing , Liu Qianqi

Background: BMI has a negative impact on spontaneous and stimulated GH secretion in children, but the impact of BMI and free fatty acids (FFA) on peak stimulated GH values in Han children with short stature is unknown.Objective and hypotheses: To assess the effects of BMI and FFA on peak GH values in Han children with short stature.Method: This was a retrospective, cross-sectional study. We used arginine–clonidine test to anal...