hrp0097p1-291 | GH and IGFs | ESPE2023

Adult heights of the cases whose GH treatment was discontinued at early retesting reached their target heights

Vuralli Dogus , Ozon Alev , Gonc Nazli

Background: It has been reported that 25–75% of patients with diagnosis of growth hormone deficiency (GHD) may show normal growth hormone (GH) responses in repeated stimulation tests after completion of treatment. Retests are typically conducted following completion of growth phase. In a small number of studies retests are conducted during early stages of GH therapy. Accuracy of early retesting to exclude GHD can be evaluated by adult heights of those wh...

hrp0097p1-491 | GH and IGFs | ESPE2023

Priming with sex steroids increases the specificity of GH tests in the diagnosis of “True” isolated growth hormone deficiency

Vuralli Dogus , Ozon Alev , Gonc Nazli

Background and Aim: Priming with sex steroids before growth hormone (GH) stimulation tests is considered to increase the specificity of the GH stimulation tests, however, its use in the diagnosis of growth hormone deficiency (GHD) is still controversial. Purpose of this study is to analyze efficacy of sex steroid priming in the diagnosis of GHD.Methods: The study comprised 115 peripubertal boys who were diagnosed with is...

hrp0089p2-p329 | Pituitary, Neuroendocrinology and Puberty P2 | ESPE2018

Gender-Related Differences in Etiological Distribution of Organic Causes of Central Precocious Puberty

Vuralli Dogus , Ozon Alev , Gonc Nazli , Kandemir Nurgun , Alikasifoglu Ayfer

Introduction: Organic lesion underlying central precocious puberty (CPP) is common in boys, and rare in girls. We aimed to compare the etiological distribution of organic causes according to gender, and define the clinical-laboratory characteristics that predict an organic cause to CPP.Subject and methods: Medical records of 260 girls and 120 boys with CPP were reviewed retrospectively to analyze the clinical, laboratory characteristics, radiological fin...

hrp0082p1-d2-154 | Growth (1) | ESPE2014

Clinical and Laboratory Parameters Predicting a Requirement for Reevaluation of GH Status During GH Treatment

Vuralli Dogus , Gonc Nazli , Ozon Alev , Alikasifoglu Ayfer , Kandemir Nurgun

Background: Reevaluation of children diagnosed as GH deficiency (GHD) showed 25–75% of cases had normal GH responses in retests after cessation of therapy. Low reproducibility and high intra-individual variability of the tests are the important problems in diagnosis. Repeat evaluation during treatment may help detect cases with normal GH status earlier.Objective and hypotheses: We repeated stimulation tests following the first year of GH treatment t...

hrp0089rfc9.3 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2018

What is the Best Parameter to Decide the Initial Dose of Depot Leuprolide Acetate in Girls with Idiopathic Central Precocious Puberty?

Vuralli Dogus , Alikasifoglu Ayfer , Iyigun Irem , Canoruc Dicle , Ozon Alev , Gonc Nazli , Kandemir Nurgun

Introduction: Formulations and doses of GnRH analogues used to treat idiopathic central precocious puberty (iCPP) may vary with clinician preference or local approvals. Aim of this study is to define factors that affect initial depot leuprolide acetate (LA) dose which suppress hypothalamo-pituitary-gonad (HPG) axis in girls with iCPP.Methods: A total of 220 girls receiving LA for iCPP were included. LA is started in the dose of 3.75 mg/28 days, and suppr...

hrp0089p1-p130 | Fat, Metabolism and Obesity P1 | ESPE2018

The Frequency of Obstructive Sleep Apnea in Children with Hypothalamic and Exogenous Obesity

Iyigun Irem , Alikasifoglu Ayfer , Ozon Alev , Gonc Nazli , Hizal Mina , Eryilmaz Sanem , Kiper Nural , Ozcelik Ugur

Introduction: Hypothalamus is an important regulator of sleep onset, sleep maintenance and wakefulness as well as appetite control. Thus, hypothalamic damage can lead to both sleep dysregulation and severe morbid obesity. So, sleep apnea may be more prevalent and severe in obesity due to hypothalamic damage in comparison to exogenous obesity.Aim: We aim to compare frequency and severity of obstructive sleep apnea (OSA) in children with hypothalamic and e...

hrp0089p1-p154 | GH & IGFs P1 | ESPE2018

Early Onset GH Replacement in GH Deficiency: Is Neonatal Hypoglycemia Important for Long Term Follow-Up?

Alikasifoglu Ayfer , Emet Sadiye Dicle , Ozon Alev , Gonc Nazlı , Kandemir Nurgun

A small number of GH deficient patients can be recognized before age 3, and only few of them are diagnosed during work-up for hypoglycemia. Data comparing clinical and laboratory characteristics of hypoglycemic vs non-hypoglycemic population of children with early onset GH deficiency is scarce. The aim of this study is to assess long-term follow-up of growth hormone therapy in early onset GH deficiency, and compare pre-treatment and treatment related factors with respect to hi...

hrp0086p1-p196 | Diabetes P1 | ESPE2016

Development of Type 1 Diabetes in a Child with Inherited CD59 Deficiency Treated with Eculizumab

Koca Serkan Bilge , Ozon Alev , Alikasifoglu Ayfer , Haliloglu Goknur , Topaloglu Haluk

Background: CD59 is a complement regulatory protein which inhibits membrane attack complex protecting self-cells from complement-mediated damage. Recent evidence suggests CD59 may suppress T cell activation via a complement-independent mechanism. Other than an immune regulator, CD59 is shown to regulate glucose stimulated insulin secretion. Herein we report a patient with inherited CD59 deficiency who developed type 1 diabetes.Case: 11 year-old girl was ...

hrp0084p2-244 | Diabetes | ESPE2015

Diabetes Mellitus and Hypoparathyroidism in a Girl with Mitochondrial Disease

Buyukyilmaz Gonul , Gonc Nazli , Haliloglu Goknur , Talim Beril , Ozon Alev , Alikasifoglu Ayfer , Kandemir Nurgun

Background: Mitochondrial disease is an uncommon cause of diabetes mellitus and hypoparathyroidism in children. Coexistence of these two endocrinopathies in a child with mitochondrial disease is extremely rare.Case report: An 11-year-old girl was diagnosed with type 1 diabetes mellitus due to a blood glucose of 300 mg/dl. Simultaneous C-peptide and insulin were very low, however anti-GAD, anti-islet cell and anti-insulin antibodies were negative. HbA1c w...

hrp0084p3-1080 | Hypo | ESPE2015

Severe Congenital Hyperinsulinism in a Neonate Homozygous for Two Novel Missense Mutations in the KCNJ11 Gene

Ozon Alev , Alikasifoglu Ayfer , Ellard Sian , Flanagan Sarah , Gonc Nazli , Orhan Diclehan , Ekinci Saniye , Kandemir Nurgun

Background: Congenital hyperinsulinism (CHI) is a heterogenous disorder characterized by hyperinsulinaemic hypoglycaemia, and may present in the neonatal period in severe forms of the disease. Molecular defects involving eight genes has been described so far. Herein we report a case of severe, diazoxide unresponsive CHI caused by two homozygous novel missense mutations in the KCNJ11 gene.Case report: An 8-day old girl was referred for hyperinsul...