ESPE Abstracts

Background: Patients with congenital adrenal hyperplasia (CAH) are glucocorticoid deficient and require cortisol replacement to maintain homeostasis and prevent adrenal crises. Hydrocortisone dosing needs to be individualized because of variable cortisol clearance rates. Patients are thus prone to be either over or undertreated, both of which compromises final height.Objective and hypotheses: Performing 24-h cortisol profiling serially may allow for more...

Background: Craniopharyngiomas are the commonest pituitary tumours of childhood. Though benign histologically, their localisation and invasive tendency can cause significant neuroendocrine morbidity and late mortality.Objective and hypotheses: To prospectively determine risk factors for neuroendocrine morbidity by longitudinal survival analysis.Method: All children with craniopharyngioma newly presenting to our quaternary centre be...

Introduction: Osteoporosis is well described among children with rheumatological conditions. Data on the specific bone deficits and microarchitectural alterations in this group of children are limited. This study aimed to assess the bone microarchitectural alterations in children with rheumatological conditions on long-term glucocorticoids using high-resolution peripheral quantitative computed tomography (HR-pQCT).Methods:</stron...