hrp0092p1-34 | Diabetes and Insulin | ESPE2019

Serum Dipeptidyl peptidase-4 Activity and its Relation to Insulin Resistance in Type 1 Diabetic Adolescents

Hana Mona , Madani Hanan , Ibrahim Amany , Soliman Hend , Salah Shimaa

Background: Insulin resistance (IR) plays a larger role in type 1 diabetes (T1D) disease process than is commonly recognized. Dipeptidyl peptidase-4 (DPP-4) is an enzyme that is expressed on almost all cell surfaces. It deactivates many bioactive peptides involved in glucose regulation; glucose-dependent insulinotropic polypeptide and Glucagon-like peptide-1.Objectives: This study evaluates serum DPP-4 activity in adoles...