hrp0095p1-380 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Effect of Long Acting Gonadotropin Releasing Hormone Agonists on Height Outcome in Children

Sahmoud Shaimaa , Gupta Sanjay , Greetham Sandra

Gonadotropin releasing hormone agonists (GnRHa) stops premature sexual maturation in young children and preserve the potential of achieving acceptable adult height.Aim: To assess the efficacy of long acting GnRHa in suppressing early pubertal development and its impact on height outcome in our patient population.Methods: Records of children treated with GnRHa since 2018 at Hull University Hospital;...

hrp0097p1-246 | Fat, Metabolism and Obesity | ESPE2023

Obesity Caused by Mutations in the Melanocortin 4 Pathway: Experience From a Teaching Hospital

Gupta Sanjay , Dalpathadu Sanjalee , Mathew Verghese , Greetham Sandra

Introduction: The role of genetics in obesity is a much under discussed area. Whilst it is undeniable that environmental factors play a major role in obesity in most cases, there is a small proportion of cases where genetic mutations are the main underlying cause. This includes novel monogenic conditions involving mutations in the Melanocortin-4 receptor (MC4R) signalling pathway. In a healthy individual, the post-meal increase in leptin (LEP) stimulates melan...