hrp0082p2-d3-437 | Growth Hormone (2) | ESPE2014

Long-Term Effects of GH Replacement Therapy on Thyroid Function in GH Deficiency Children

Esposito Andrea , Donato Iolanda Di , Rezzuto Martina , Alfano Sara , Moracas Cristina , Capalbo Donatella , Salerno Mariacarolina

Background: Several studies have investigated the effects of GH replacement therapy (GHRT) on thyroid function in children with GH deficiency (GHD) leading to contrasting results. Indeed, GHRT has been reported to affect the peripheral metabolism of thyroid hormones, to alter TSH secretion by pituitary and to unmask secondary hypothyroidism.Objective and hypotheses: To evaluate long-term effects of GHRT on thyroid function in a large cohort of GHD childr...

hrp0092p1-409 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (2) | ESPE2019

Long-Term Outcome in Young Women Treated for Central Precocious Puberty

Improda Nicola , Alfano Sara , Anselmi Federica , Gaeta Valeria , Bufalo Lorenzo , Santamaria Fabiana , Di Mase Raffaella , Salerno Mariacarolina

Background: GnRH-analogs (GnRHa) are the recommended treatment for Central Precocious Puberty (CPP). Despite a normal long-term outcome is generally reported, reproductive function and emotional sphere in adulthood are still poorly evaluated.Objective: To evaluate the general long-term outcome of young women with previous CPP treated with GnRHa.Patients and Methods: A cohort of 63 ...

hrp0086p1-p904 | Thyroid P1 | ESPE2016

Cardiac Size and Function in Children with Subclinical Hypothyroidism

Alfano Sara , Arcopinto Michele , Cerbone Manuela , Improda Nicola , Di Mase Raffaella , Ungaro Carla , Salzano Andrea , Cittadini Antonio , Salerno Mariacarolina

Background: The management of subclinical hypothyroidism (SH) is still challenging in particular for mild forms with TSH levels ranging between 4.5 and 10 mU/L.Objective and hypotheses: to compare left ventricular (LV) geometry and function of SH subjects and matched euthyroid controls, and to evaluate the effect of L-thyroxine (L-T4) therapy on cardiac parameters.Method: Thirty-six (36) children (19 females and 17 males), aged 8.6...

hrp0082p3-d1-975 | Thyroid | ESPE2014

Prevalence of Additional Autoimmune Diseases in Autoimmune’s Thyroiditis Children and Their First- and Second-Degree Relatives: Results from a Large, Single-Center Study

De Martino Lucia , Di Donato Iolanda , Alfano Sara , D'Acunzo Ida , Di Pinto Rosita , Capalbo Donatella , Salerno Mariacarolina

Background: Autoimmune’s thyroiditis (AT) is the most common cause of thyroid diseases in children and adolescents with a peak in early to mid-puberty (prevalence of 0.3–1.2%). Previous studies showed a high rates of familiarity for autoimmune disease (AD) and co-existing autoimmunity in AT subjects.Objective and hypotheses: Aim of our study is to investigate familiarity for AD and co-existing autoimmunity in a large cohort of pediatric AT pati...

hrp0084fc13.5 | Thyroid | ESPE2015

Effect of 2 Years of Treatment with Levothyroxine on Cardiovascular Risk Factors in Children with Mild Idiopathic Subclinical Hypothyroidism

Cerbone Manuela , Wasniewska Malgorzata , Alfano Sara , Capalbo Donatella , Di Mase Raffaella , Improda Nicola , De Luca Filippo , Salerno Mariacarolina

Background: The benefits of levothyroxine (L-T4) therapy in subjects with mild SH (TSH between 5 and 10 mU/l with normal FT4 values) are controversial. Current recommendations in adults suggest to start on treatment selected groups of subjects with mild SH and evidence of atherosclerotic CV disease. Data in children are lacking.Objective and hypotheses: To investigate the effect of L-T4 treat...