hrp0084p3-721 | Diabetes | ESPE2015

GAD Antibodies Negative Type 1 Diabetes and Dravet Syndrome

Ciccone Sara , Marini Romana , Fusco Lucia , Terracciano Alessandra , Schiaffini Riccardo , Cappa Marco

Background: An association between type 1 diabetes mellitus (T1DM) and idiopathic generalized epilepsy is reported. Some authors suggest an autoimmune mechanism mediated by antibodies to glutamic-acid-decarboxylase (GAD), that is an enzyme involved in the synthesis of the neurotransmitter GABA. Dravet syndrome (DS) is a rare, severe epilepsy disorder characterized by febrile hemiclonic seizures or generalized status epilepticus starting at 6 months of age. In classical DS, a d...

hrp0095p1-442 | Diabetes and Insulin | ESPE2022

A Continuous Quality Improvement Effort Implemented by The Italian Network of Pediatric Diabetes Clinics

Zucchini Stefano , Bonfanti Riccardo , Lombardo Fortunato , Nicolucci Antonio , Rabbone Ivana , Schiaffini Riccardo , Vespasiani Giacomo

Pediatric diabetes management extends beyond glycemic control. A gap between guidelines and actual care exists. Standardized performance measures represent a key strategy to improve quality of care. In Italy, a non-profit initiative of continuous monitoring and quality improvement of diabetes care is in place since 2018, promoted by the ISPEDCARD association and involving the Society for Pediatric Endocrinology and diabetology (ISPED). Aim of the present work is to report the ...

hrp0092fc7.3 | Diabetes and Insulin Session 2 | ESPE2019

MicroRNA Circulating Levels in Children at Diagnosis of Type 1 Diabetes

Inzaghi Elena , Rapini Novella , Deodati Annalisa , Schiaffini Riccardo , Patera Patrizia , Matteoli Maria Cristina , Ciampalini Paolo , Cianfarani Stefano

Background: Type 1 diabetes (T1D) is a chronic disease characterized by autoimmune destruction of pancreatic beta-cells. Dysregulated miRNA levels have been described in T1D patients, though results are inconclusive.Objective and Hypotheses: The aim of this study was to assess the circulating profile of different miRNAs in children at diagnosis of T1D.Method: 27 children with T1D o...

hrp0089p1-p073 | Diabetes & Insulin P1 | ESPE2018

Efficacy of Real-time Continuous Glucose Monitoring in Type 1 Diabetic Pre-school and School Children Treated with Multiple Daily Injections

Schiaffini Riccardo , Rapini Novella , Pellicano Grazia , Patera Patrizia Ippolita , Ciampalini Paolo , Matteoli Maria Cristina , Deodati Annalisa , Cianfarani Stefano

Background: Young children affected by Type 1 Diabetes (T1D) are prone to glucose fluctuations and hardly reach a stable glycometabolic control, especially when treated with a Multiple Daily Insulin Injections (MDI) scheme. The recent Real-Time Continuous Glucose Monitoring (RT-CGM) System, Dexcom G5, the only available device registered for non-adjunctive insulin intervention, potentially facilitates a better management of the disease. Evidence regarding CGM effectiveness amo...

hrp0095p1-61 | Diabetes and Insulin | ESPE2022

Increased incidence of childhood type 1 diabetes during COVID-19 pandemic. Figures from an Italian tertiary care center

Deodati Annalisa , Rapini Novella , Pampanini Valentina , Ciampalini Paolo , Cristina Matteoli Maria , Patriza Patera Ippolita , Schiaffini Riccardo , Stefano Cianfarani

Background: CDC (Centers for Disease Control and Prevention) reported an increased risk of newly diagnosed diabetes over 30 days after SARS-CoV-2 infection among persons aged < 18 years. Similarly, the results from the DPV Registry demonstrated a significant increase in the incidence of pediatric Type 1 Diabetes during COVID-19 pandemic. The underlying mechanisms are not yet elucidated.Aim: To investigate the incidenc...

hrp0095p1-247 | Diabetes and Insulin | ESPE2022

Monogenic diabetes clinic: 3-year experience

Rapini Novella , Ippolita Patera Patrizia , Schiaffini Riccardo , Ciampalini Paolo , Pampanini Valentina , Cristina Matteoli Maria , Deodati Annalisa , Bracaglia Giorgia , Porzio Ottavia , Novelli Antonio , Mucciolo Mafalda , Cianfarani Stefano , Barbetti Fabrizio

Background: In Italy monogenic forms of hyperglycemia account for more than 6% of cases referred to pediatric diabetes clinics. In January 2019 we started a Monogenic Diabetes Clinic (MDC) with the three main aims: a) implementing a standardized pathway towards genetic testing, 2) ease the revision of complex cases, 3) implement standardized therapies for monogenic diabetes mellitus (MDM) subtypes.Methods: Type 1 diabete...