ESPE Abstracts

Background: During treatment of adrenal insufficiency (AI) with hydrocortisone (HC), cortisol concentrations are supra-physiological following doses, and low before doses. We speculated that this cortisol profile may result in periods of hyperglycaemia and hypoglycaemia. We describe glucose profiles in the first 18 children recruited to a study of metabolic and cardiovascular profiles in AI. Methods: Children with primar...

Background: Increased risk of cardiovascular disease and increased subclinical atherosclerosis have been reported in children with primary adrenal insufficiency (AI), including those with congenital adrenal hyperplasia (CAH), when compared to healthy children. Carotid intima media thickness (CIMT) can be used as an early marker of cardiovascular risk. The severity of adverse metabolic profile has been related to the total hydrocortisone dose and duration of tr...

Background: Cortisol is a hormone critical for good health. Concentrations of cortisol are reported to be increased in people born small for gestational age and obese children. Cortisol excess and deficiency are associated with growth disturbances and changes in blood pressure (BP). Salivary cortisol (SC) and cortisone (SCn) correlate strongly with serum cortisol. In this study we investigated the relationship between SC and SCn, auxological parameters, BP, ag...