ESPE Abstracts

Background: Currently, only two centers for diagnosis and treatment of growth disorders are operating in the Western and Eastern parts of Bulgaria. About 200 children are currently GH treated while at least as many children with growth disorders from mostly Central Northern and Southern Bulgaria are presumably not diagnosed. Thus inequalities in children's access to health care are created. In order to correct this and to quickly align practices between ex...

Background: Obesity is a major risk factor for developing type 2 diabetes mellitus (T2DM). Despite the obesity epidemics, the incidence of childhood T2DM is not increased.Objective and hypotheses: To assess the β-cell reserve expressed as an oral glucose disposition index (GDIo), an independent predictor of developing T2DM.Method: A total of 80 adolescents (61.3% girls), aged from 10.0 to 17.6 years (mean age 13.59±2.34 y...

Background: Obesity prevalence is increasing among young children in both developed and developing countries, showing a tendency to persist with age and lead to early morbidity and mortality.Objective and hypotheses: The aim of this study is to present the most recent trend in obesity prevalence and to investigate the changes in BMI among Bulgarian pre-pubertal children for a period of 17 years (from 1990 to 2007).Method: Three cro...

Background: Recently childhood obesity shows trends of lowering age at start. Preschool children are still very physically active. A possible association between total and abdominal obesity and metabolic risk at preschool age could be of value for preventive measures.Objective and hypotheses: To investigate the relationship between body composition and some metabolic risk factors at preschool age.Method: A total of 40 (50% boys) he...

Background: Non-classical congenital adrenal hyperplasia (NCCAH) is a hyperandrogenic disorder affecting negatively the psychological health and the quality of life (QoL) of patients.Aim: To evaluate the psychological health and QoL in female NCCAH patients in comparison to female age-matched healthy controls.Participants and Methods: A total of sixty-eight females, aged 10-27 year...

Background: Polycystic ovary syndrome (PCOS) is the most common hyperandrogenic disorder in pubertal girls affecting between 3 and 11 % of them. Menstrual irregularities and hyperandrogenism are the main characteristics of the syndrome. PCOS is associated with obesity, cardiovascular complications, impaired fertility and increased cancer risk in adulthood. Some of these complications are potentially preventable with timely diagnosis, life-style change and phar...

Background: Activity dependent neuroprotective protein (ADNP) syndrome (OMIM: 615873), also known as Helsmoortel Van Der Aa syndrome (HVDAS), is an autosomal dominant monogenic neurodevelopmental disorder caused by ADNP gene mutations. It is characterized with impaired learning and motor skills, hypotonia, dysmorphic features, organ anomalies, behavioral and psychiatric problems.Aim: To present a female patient with HVDA...

Background: Turner syndrome (TS) is a common chromosomal disorder affecting approximately 1:2500 live female births caused by partial or complete absence of one X chromosome. Its most common clinical features are short stature and gonadal insufficiency. Only about a third of girls with Turner syndrome may have spontaneous puberty.Objective: The aimof this case presentation is to describe the clinical manifestations in th...

Background: Precocious pubarche (PP), defined as the development of pubic hair before 8 years of age in females could be the first sign of a hyperandrogenic condition.Aim: The purpose of the study was to analyze the etiology of premature androgenization of girls with a history for PP and to evaluate their clinical, laboratory and ovarian ultrasound profile.Material and methods: A t...

Background: Non-classic congenital adrenal hyperplasia (NCCAH) is a genetic disorder characterized by hyperandrogenism associated with potential metabolic alterations and changes in body composition and bone mineral parameters.Aim: The purpose of this pilot study was to evaluate the clinical and biochemical characteristics in association with bone mineral parameters and body composition in female patients diagnosed with ...