hrp0084p2-391 | Fat | ESPE2015

POMC DNA Hypermethylation Variant is Highly Associated with Obesity in Adults

Kuhnen Peter , Handke Daniela , Spranger Jochen , Fischer-Rosinsky Antje , Hinney Anke , Hebebrand Johannes , Gruters Annette , Krude Heiko

Background: POMC plays a major role in central body weight regulation. Recently we have shown that a POMC hypermethylation variant is significantly associated with obesity in children and adolescents (Kuehnen et al. PLoS Genetics 2012).Objective and hypotheses: Here we report about our extended studies to elucidate the mechanism behind the occurrence of the POMC hypermethylation variant in obese individuals.<p clas...