hrp0097p1-441 | Diabetes and Insulin | ESPE2023
Vourdoumpa Aikaterini
, Paltoglou George
, Sertedaki Amalia
, Sakou Irini-Ikbale
, Karanasios Spyridon
, Karavanaki Kyriaki
, Charmandari Evangelia
Introduction: HNF1B gene (OMIM*189907) encodes the transcription factor HNF1B, which is expressed early in embryogenesis, controls gene expression and is involved in multiple tissue and organ development. Mutations of HNF1B account for a complex disorder with multisystemic manifestations (Renal Cysts and Diabetes syndrome, OMIM #137920). Congenital urinary tract abnormalities and HNF1B MODY, a rare cause of diabetes mellitus (DM) (≤5% of M...