hrp0086p2-p54 | Adrenal P2 | ESPE2016

Hyperandrogenism in a 12-year Old Girl with a Congenital Porto-Systemic Shunt and Congenital Hepatic Fibrosis

Danko Mikolaj , Kot Karolina , Szalecki Mieczysław , Moszczynska Elzbieta , Malinowska Anna

Background: Hyperandrogenism in children is associated with excessive adrenal or gonadal androgens secretion. The most common causes of androgens hypersecretion are PCOS, adrenal tumors, CushingÂ’s syndrome, CAH, and gonadal virilizing tumors. Within the last 15 years single case-reports of hyperandrogenism in female patients with congenital porto-systemic shunts were described in literature. The mechanism of such coincidence is unknown but the role of hyperinsulinism, imp...

hrp0086p2-p765 | Pituitary and Neuroendocrinology P2 | ESPE2016

Symptomatic Rathke Cleft Cyst in Pediatric Patients – Clinical Presentations, Surgical Treatment and Postoperative Outcomes – An Analysis of 38 Cases

Prokop Monika , Moszczyńska Elżbieta , Bogusz Agnieszka , Daszkiewicz Paweł , Szalecki Mieczysław , Roszkowski Marcin

Background: Rathke cleft cysts are benign, epithelium-lined intrasellar and/or suprasellar cysts believed to originate from remnants of the Rathke pouch. Although its prevalence in adults is rather high, Rathke cleft cysts are rare in children. Often they are asymptomatic findings, however depending on their size and localization they can present with a wide spectrum of symptoms.Objective and hypotheses: The aim of the study was to analyse the symptoms a...

hrp0094p2-455 | Thyroid | ESPE2021

Expression of Zinc transporter 8 in thyroid tissues from patient with immune and non-immune thyroid diseases

Bossowski Artur , Niklinska Wiesława , Gasowska Marta , Polnik Dariusz , Szalecki Mieczysław , Mikłosz Agnieszka , Chabowski Adrian , Reszec Joanna

Introduction: Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet autoantigen in type 1 diabetes.Materials and methods: We studied the expression of ZnT8 transporter in thyroid tissues from patients with im...