hrp0097p1-451 | Fat, Metabolism and Obesity | ESPE2023

Diagnostic Journey with an 80-gene Panel in Non-syndromic Early-Onset Severe Obesity: Association of Outcomes with Metabolic Status and Hyperphagia

Tercan Ummahan , Yildiz Melek , Dilruba Aslanger Ayca , Derya Kardelen Al Asli , Poyrazoglu Sükran , Bas Fİrdevs , Darendeliler Feyza

Background: Monogenic defects are among the significant causes of early-onset non-syndromic severe obesity in childhood. Identifying the genetic cause of obesity can guide for treatment. The aim of our study is to investigate the clinical and biochemical features of patients with early-onset severe obesity and evaluate the underlying molecular diagnosis.Materials and Methods: A total of 39 patients (M/F: 22/17) with non-...

hrp0097p1-105 | GH and IGFs | ESPE2023

Effects of Growth Hormone Therapy on Glucose Metabolism in Children and Adolescents: 1-year follow-up results

Derya Kardelen Aslı , Kandemir Tuğçe , Demirel Özge , Tercan Ummahan , Yıldız Melek , Poyrazoğlu Şükran , Baş Firdevs , Darendeliler Feyza , Marja Ojaniemi

Introduction: It is thought that long-term growth hormone (GH) treatment may impair hepatic glucose production and insulin-dependent glucose utilization, and therefore it is attributed that GH may adversely affect glucose metabolism.Objective: In our study, we aimed to examine the effects of GH treatment on insulin sensitivity and glucose metabolism in patients with GH deficiency after 1-year of treatment.<p class="a...