hrp0084p2-193 | Adrenals | ESPE2015

Adrenal Function in Children Born Small for Gestational Age

Petraitiene Indre , Verkauskiene Rasa

Background: Subjects born small for gestational age (SGA) were shown to be at higher risk to metabolic consequences later in life and this might be related to changes in hypothalamic–pituitary–adrenal axis.Objective and hypotheses: We aimed to investigate DHEAS and cortisol levels in adolescents born SGA or appropriate for gestational age (AGA) and their relationship with perinatal and postnatal factors.Method: A prospect...

hrp0089p1-p027 | Bone, Growth Plate & Mineral Metabolism P1 | ESPE2018

Bone Health in Adolescents Born Small for Gestational Age (SGA)

Petraitiene Indre , Basevicius Algidas , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Subjects born small for gestational age (SGA) are at higher risk for metabolic, hormonal and reproductive problems later in life and about 2–10% of children born SGA do not catch-up in height. All these changes may influence bone mineral density (BMD).Aim: To evaluate hormonal profile and BMD in adolescents born SGA in comparison to their peers born appropriate for gestational age (AGA).Methods: 103 children were e...

hrp0086p1-p485 | Fat Metabolism and Obesity P1 | ESPE2016

What are Early Predictors of Impaired Glucose Tolerance in Children Born SGA?

Petraitiene Indre , Jasinskiene Edita , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Subjects born small for gestational age (SGA) were shown to be at higher risk to later metabolic consequences but early prediction factors of changes in glucose metabolism are not clearly known.Objective and hypotheses: We aimed to investigate glucose tolerance and insulin resistance in adolescents born SGA or appropriate for gestational age (AGA) and their relationship with perinatal and postnatal factors.Method: A pro...

hrp0082p3-d3-938 | Puberty and Neuroendocrinology (1) | ESPE2014

Hyperandrogenism Doesn’t Increase the Insulin Resistance in Overweight and Obese Adolescent Girls with Polycystic Ovary Syndrome

Smetanina Natalija , Seibokaite Audrone , Valickas Raimondas , Verkauskiene Rasa

Background: Polycystic ovary syndrome (PCOS) is associated with metabolic abnormalities and increased insulin resistance (IR), which is closely associated with abdominal obesity and hyperandrogenism in adults. Some studies indicate that hyperandrogenism influences insulin resistance development in PCOS patients. Data on PCOS association with risks of metabolic disorders in adolescence are scars.Objectives: In this study we aimed to investigate androgen p...

hrp0084p1-135 | Turner & Puberty | ESPE2015

Sex Hormones and Gonadal Size in Pubertal Girls Born Small or Appropriate for Gestational Age

Petraitiene Indre , Verkauskiene Rasa , Jariene Kristina , Vitkauskiene Astra

Background: Small for gestational age (SGA) birth size has been associated with various metabolic, hormonal and reproductive problems in later life.Objective and hypotheses: We aimed to compare differences in sex hormones, uterine and ovarian sizes in SGA and appropriate for gestational age (AGA) adolescent girls.Method: 23 SGA and 47 AGA pubertal 11–14 years old girls (median age 13.2±1.94 years, median pubertal stage 4&...

hrp0092lb-9 | Late Breaking Posters | ESPE2019

Left Ventricular Mass Index and Cardiovascular Function in Adolescents Born Small for Gestational Age (SGA)

Petraitiene Indre , Kasparaviciene Jurate , Valuniene Margarita , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Subjects born small for gestational age (SGA) were shown to be at higher risk for metabolic consequences in adulthood but less is known on their cardiovascular function.Objective and Hypotheses: We aimed to investigate cardiovascular function and left ventricular mass index (LVMI) in adolescents born SGA and appropriate for gestational age (AGA) and their relationship with perinatal and postnatal factors....

hrp0094p1-154 | Fetal Endocrinology and Multisystem Disorders B | ESPE2021

The Evaluation of Accuracy and Effectiveness of Newborn Screening for Congenital Adrenal Hyperplasia in Lithuania

Navardauskaite Ruta , Baneviciute Kornelija , Mockeviciene Giedre , Songailiene Jurgita , Grigalionienė Kristina , Smirnova Marija , Utkus Algirdas , Verkauskiene Rasa ,

Introduction: The main reason for Newborn screening (NBS) for congenital adrenal hyperplasia (CAH) is to prevent adrenal insufficiency that can lead to life-threatening conditions. On the other hand, screening programmes are not always sensitive and effective enough to detect the disease. We aimed to evaluate the specificity, sensitivity and efficiency of the national NBS for CAH in Lithuania.Methods: retrospective study...

hrp0095p1-2 | Adrenals and HPA Axis | ESPE2022

Growth evaluation by applying the QEPS growth model in patients with CAH

Navardauskaite Ruta , Verkauskiene Rasa , Niklasson Aimon , F.M Nierop Andreas , Albertsson-Wikland Kerstin , Holmgren Anton

Objective: Patients with congenital adrenal hyperplasia (CAH) seldom achieve their target height. Early adrenarche may accelerate bone age maturation and affect adult height. The QEPS-growth-model have been used for developing growth references and investigating healthy/pathological growth, however, not before used in individuals with endocrine disorders. This study aimed to evaluate growth patterns in CAH-patients with the QEPS-model.<s...

hrp0095p1-443 | Diabetes and Insulin | ESPE2022

Co-segregation analysis and functional trial in vivo of candidate genes for monogenic diabetes

Ingrida Stankute , Kazokaite Mintaute , Blouin Jean-Louis , M. Schwitzgebel Valerie , Verkauskiene Rasa

The aim of this study was to perform familial co-segregation analysis and functional trial in vivo during mixed meal tolerance test (MMTT) of novel variants in diabetes candidate genes.Methods: This study is a continuation of collaborative research project “Genetic diabetes in Lithuania” with the cohort of 1209 young diabetes patients. Prior screening for GADA, IA-2, IAA, ZnT8A confirmed type 1 diabetes (T1D) diagnos...

hrp0092p2-70 | Diabetes and Insulin | ESPE2019

Evaluation of β-cell Function in Young MODY Patients using a Mixed Meal Tolerance Test

Stankute Ingrida , Morkunaite Ausra , Dobrovolskiene Rimante , Danyte Evalda , Razanskaite-Virbickiene Dovile , Jasinskiene Edita , Mockeviciene Giedre , Schwitzgebel Valerie , Verkauskiene Rasa

Background: Mixed meal tolerance test (MMTT) is a gold standard for evaluating β-cell function. There is limited data on MMTT and β-cell function in MODY patients.Objective: The aim was to analyze plasma C-peptide (CP) levels during MMTT in MODY patients as a biomarker of β-cell function.Methods: The cohort consisted of 39 patients with MODY genes mutations:...