hrp0084p3-874 | Fat | ESPE2015

Relation between Thyroid Function Tests and Cardiometabolic Risk Factors in Childhood Obesity

Vuralli Dogus , Tapci Esra , Dallar Yildiz Bilge

Background: It is known that obese children are at higher risk in terms of cardiovascular diseases when compared with normal weight children. Recent studies emphasizes on the fact that there is a relation between TSH and several cardiovascular risk factors in obese children.Objective and hypotheses: The aim of the study is to investigate the relation between cardiometabolic risk factors and thyroid function tests in obese children....

hrp0095fc11.5 | Late Breaking | ESPE2022

Serum kisspeptin, neurokinin B and inhibin B levels can be used as an auxiliary parameter to distinguish idiopathic CPP from premature thelarche in the early stages of puberty

Vuralli Dogus , Ciftci Nurdan , Demirbilek Huseyin

Background: There are controversial results among the results of various studies evaluating diagnostic utility of kisspeptin, NKB, AMH, and INHB for demonstrating activation of hypothalamic-pituitary-gonadal axis in girls with CPP.Aim: To evaluate these 4 neuropeptides in the same individuals who presented with early pubertal signs and their validity in the diagnosis and differential diagnosis of CPP.<p class="abstex...

hrp0089p2-p192 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Hyperinsulinemic Hypoglycemia in Congenital Disorder of Glycosylation Type-1a (CDG-1a)

Vuralli Dogus , Yildiz Yilmaz , Serap Sivri H. , Alikasifoglu Ayfer

Introduction: Congenital disorder of glycosylation type-1a is a multi-system disease involving neurological, gastrointestinal, ophthalmologic, cardiac or endocrine systems. In addition to hypothyroidism and hypergonadotropic hypogonadism, rare occurrences of hyperinsulinemic hypoglycemia in CDG patients have been reported. In the present report, we describe a patient diagnosed with CDG type-1a accompanied by hyperinsulinemic hypoglycemia, and whose responsive to diazoxide....

hrp0089p2-p329 | Pituitary, Neuroendocrinology and Puberty P2 | ESPE2018

Gender-Related Differences in Etiological Distribution of Organic Causes of Central Precocious Puberty

Vuralli Dogus , Ozon Alev , Gonc Nazli , Kandemir Nurgun , Alikasifoglu Ayfer

Introduction: Organic lesion underlying central precocious puberty (CPP) is common in boys, and rare in girls. We aimed to compare the etiological distribution of organic causes according to gender, and define the clinical-laboratory characteristics that predict an organic cause to CPP.Subject and methods: Medical records of 260 girls and 120 boys with CPP were reviewed retrospectively to analyze the clinical, laboratory characteristics, radiological fin...

hrp0082p1-d2-154 | Growth (1) | ESPE2014

Clinical and Laboratory Parameters Predicting a Requirement for Reevaluation of GH Status During GH Treatment

Vuralli Dogus , Gonc Nazli , Ozon Alev , Alikasifoglu Ayfer , Kandemir Nurgun

Background: Reevaluation of children diagnosed as GH deficiency (GHD) showed 25–75% of cases had normal GH responses in retests after cessation of therapy. Low reproducibility and high intra-individual variability of the tests are the important problems in diagnosis. Repeat evaluation during treatment may help detect cases with normal GH status earlier.Objective and hypotheses: We repeated stimulation tests following the first year of GH treatment t...

hrp0084p3-603 | Adrenals | ESPE2015

A Case of Phaeochromocytoma Diagnosed as Adrenal Incidentaloma

Vuralli Dogus , Agras Pinar Isik , Tapci Esra , Dallar Yildiz Bilge

Background: There are two main problems that should be solved when encountering adrenal incidentaloma. The first of these is to decide whether the adrenal mass is benign or malignant and the second is to determine whether the mass is hormonally active or not.Objective and hypotheses: We aimed to focus on the approach to adrenal masses in childhood.Method: A case of phaeochromocytoma, which was diagnosed as incidentaloma is presente...

hrp0092p1-404 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

Improvement of Final Height in Idiopathic Central Precocious Puberty is Associated with Delay of Bone Maturation with GnRH Agonist Therapy Under the Age of 7 Years

Vuralli Dogus , Gonc E. Nazli , Ozon Z. Alev , Kandemir Nurgun , Alikasifoglu Ayfer

Background: GnRHa therapy is shown to be beneficial in increasing final height when started before 6 years of age in girls with idiopathic CPP(iCPP). However controversial data exist in improvement of final height whose pubertal signs appear after age of 6.Aim: To investigate effect of age of onset of GnRHa therapy on final height n girls with iCPP, and to evaluate factors affecting height gain.<st...

hrp0092p2-59 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Spondyloocular Syndrome: Presentation of Two Siblings Diagnosed with The Rare Disease and The Results of Pamidronate Therapy

Vuralli Dogus , Simsek Kiper Pelin Ozlem , Utine Eda , Unsal Yagmur , Alikasifoglu Ayfer , Kandemir Nurgun

Spondyloocular syndrome (OMIM 605822) is an autosomal recessive disorder characterized by skeletal complaints (osteoporosis, platyspondyly, multiple bone fractures), hearing loss and ocular symptoms (cataracts, retinal detachment). XYLT2 gene (OMIM 608125) mutation encoding xylosyltransferase II enzyme which is responsible from the first step of proteoglycan assembly is responsible for the pathogenesis. Phenotypical variability is associated with varying genetic expre...

hrp0092p2-223 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Long Term Effects of GnRH Agonist Therapy on BMI in Girls with Idiopathic Central Precocious Puberty

Vuralli Dogus , Ozon Z. Alev , Gonc E. Nazli , Alikasifoglu Ayfer , Kandemir Nurgun

Background: Studies investigating effects of GnRHa therapy on body weight (BW) and BMI in subjects with CPP are generally including short term effects.Aim: To investigate changes in BMI at the beginning, during and two years after completion of GnRHa therapy to determine influential factors in girls with idiopathic CPP.Methods: Data of 138 girls who completed GnRHa therapy for iCPP...

hrp0092p2-224 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

To Whom Should Central Nervous System Imaging be Performed in Girls with Central Precocious Puberty (CPP)?

Vuralli Dogus , Gonc E. Nazli , Alikasifoglu Ayfer , Kandemir Nurgun , Ozon Z. Alev

Background: Organic lesions are present in 5-10% of cases with CPP. Determinants of an increased risk for organic pathology underlying CPP in girls are debatable. CNS imaging is recommended for girls who have pubertal signs before 6 years of age. Although neurological findings may suggest organic pathology, other clinical features and hormonal variables have not been adequately examined.Aim: To analyze clinical&h...