hrp0095p2-66 | Diabetes and Insulin | ESPE2022

A Novel Mutation in the Hepatocyte Nuclear Factor 1-Alpha Detected in Case of a 13-Year-Old Female with Maturity Onset Diabetes of the Young (MODY)

Hyang Cho Ja , Woon Jung Hae , Shik Shim Kye

Maturity onset diabetes of the young (MODY) is a rare type of non-autoimmune diabetes mellitus which usually present in young adulthood. An estimated prevalence was 1.2% within the pediatric diabetic population. To date it has been proposed that pathogenic variants in at least 14 genes cause MODY. Among these genes, most cases result from mutations in HNF1A (MODY3), GCK (MODY2), HNF4A (MODY1) and HNF1B (MODY5). The patient is a 13-year-old, previously healthy, nonobese female ...

hrp0092rfc7.4 | Diabetes and Insulin Session 2 | ESPE2019

Handgrip Strength Correlates with Insulin Resistance and the Metabolic Syndrome in Children and Adolescents: Analysis of the Korean National Health and Nutrition Examination Survey 2014-2016

Woon Jung Hae , Ah Lee Young , Yong Lee Seong , Ho Shin Choong , Won Yang Sei , Hyun Kim Jae

Introduction: Reduced muscle strength is associated with increased cardiometabolic morbidity and mortality. Handgrip strength (HGS) is an indicator of muscle strength and has been correlated with total muscle strength in children and adolescents. We aimed to evaluate the association between HGS and parameters of the metabolic syndrome and insulin resistance in children and adolescents.Methods: A total of 2,242 children a...

hrp0086p1-p463 | Fat Metabolism and Obesity P1 | ESPE2016

Exposure to Phthalates Is Associated with Overweight or Obesity in 4-Year-Old Children

Lee Jieun , Ah Lee Young , Woon Jung Hae , Young Kim Hwa , Min Lee Gyung , Youn Kim So , Jeong Kyung A. , Hee Choi Keun , Lim Youn-Hee , Bae Sanghyuk , Hong Yun-Chul , Ho Shin Choong , Won Yang Sei

Background: Childhood obesity is a major health concern. Exposure to environmental chemicals may play a role in childhood obesity.Objective and hypotheses: We investigated whether urinary phthalate metabolite concentrations was associated with overweight or obese status in 4-year-old children.Method: Forty-hundred thirteen children born as term, appropriate-for-gestational-age infants (226 males) were included in this study. BMI wa...