hrp0089p3-p188 | Fetal, Neonatal Endocrinology and Metabolism P3 | ESPE2018

Weight Outcome in Infants with Prolonged Hyperinsulinemic Hypoglycemia Treated with Diazoxide vs Those with Spontaneous Resolution

Chandran Suresh , Rajadurai Victor Samuel , Yi Chng Hui , Jinjie Lin , Lim Joyce , Peng Fabian Yap Kok

Background: In newborns, physiological transition of glucose metabolism is typically completed within 48–72 h of life, yet prolonged hyperinsulinemic hypoglycemia (HH) beyond 5d of life is not uncommonly encountered, especially in infants at-risk of hypoglycemia. Management includes intravenous dextrose while awaiting spontaneous resolution (SR) of HH or Diazoxide (DZX) therapy. Since DZX acts by suppressing insulin release, concerns arise whether weight gain in infancy w...

hrp0084p2-243 | Diabetes | ESPE2015

Dyslipidaemia in Children with Diabetes

Lim Pei Kwee , Vasanwala Rashida , Cheng Tuck Seng , Lek Ngee , Hui Yuen Ching Angela , Lim Soo Ting , Yap Fabian

Background: Data on prevalence and phenotypic distribution of dyslipidaemia in children with type 1 diabetes (T1D) is scarce. Studies have shown that lipid abnormality tracks from childhood to adulthood and contributes to atherosclerotic process, therefore initial assessment and follow-up is essential.Aims: To study the prevalence and phenotypic distribution of dyslipidaemia in children with T1D and compare with type 2 diabetes (T2D).<p class="abstex...

hrp0089p1-p026 | Bone, Growth Plate &amp; Mineral Metabolism P1 | ESPE2018

Duration of Breastfeeding and Bone Mineral Density in Childhood – A Prospective Study Among Preschool Children

Tint Mya Thway , Pang Wei Wei , Vasanwala Rashida Farhad , Padmapriya Natarajan , Ng Sharon , Soh Shu E , Chong Mary Fong-Fong , Shek Lynette Pei Chi , Gluckman Peter D , Chong Yap-Seng , Godfrey Keith M , Fortier Marielle V , Eriksson Johan G , Lee Yung Seng , Zhang Cuilin , Yap Fabian

Background: Bone growth and mineralization during childhood are now recognized as important for bone health in adulthood, leading to renewed interest in identifying modifiable factors that impact bone mineral density (BMD) in childhood. Emerging data suggest that duration of breastfeeding may affect BMD in later childhood and adult life. However, such data are sparse and inconsistent.Objectives: This study examined the relationship betwe...

hrp0089p1-p128 | Fat, Metabolism and Obesity P1 | ESPE2018

Rate of Accumulation of Abdominal Fat is Associated with Fasting Glucose Levels in Early Childhood

Anand Sadananthan Suresh , Thway Tint Mya , Michael Navin , Wei Pang Wei , Ling Loy See , Soh Shu-E , Shek Lynette , Yap Fabian , Hian Tan Kok , Kramer Michael , Eriksson Johan , Godfrey Keith , Gluckman Peter , Seng Chong Yap , Karnani Neerja , Seng Lee Yung , Fortier Marielle , Sendhil Velan S

Objectives: Abdominal fat has been strongly linked to increased cardiometabolic risk and impaired glucose regulation in adults. Owing to the lack of detailed body composition phenotyping in most previous child cohort studies, the temporal links between abdominal fat accumulation and impaired glucose regulation have not been well established. In this study, we evaluated the associations of abdominal fat assessed by MRI at early infancy (≤21 days after birth) and at 4.5 ye...

hrp0089p2-p153 | Fat, Metabolism and Obesity P2 | ESPE2018

Early BMI Trajectory Classes are Linked to Distinct Body Fat Partitioning Later in Childhood

Michael Navin , Ying Ong Yi , Sadananthan Suresh Anand , Aris Izzuddin M , Tint Mya Thway , Lun Wen Yuan , Wei Pang Wei , Ling Loy See , Soh Shu-E , Shek Lynette Pei-Chi , Yap Fabian Kok Peng , Tan Kok Hian , Godfrey Keith M , Gluckman Peter D , Chong Yap Seng , Karnani Neerja , Kramer Michael S , Eriksson Johan G , Fortier Marielle V , Velan S Sendhil , Lee Yung Seng

Background: Growth patterns in infancy and early childhood have been linked to risks of obesity and cardiometabolic disorders in adulthood. Body fat partitioning, particularly increased fat accumulation at ectopic sites, has been strongly associated with cardiometabolic disorders. However, the lack of precise body composition measures in prior longitudinal birth-cohort studies has made it difficult to ascertain if early growth patterns could result in consolidation of distinct...