hrp0086p1-p754 | Pituitary and Neuroendocrinology P1 | ESPE2016

The Metabolic Negative Effect of Gonadotropin-Releasing Hormone Agonist Therapy in Childhood: Is it Short-Term and Reversible?

Iughetti Lorenzo , Bruzzi Patrizia , Bigi Elena , Valeri Lara , Manzotti Elena , Lucaccioni Laura , Predieri Barbara

Background: Data on metabolic effects of gonadotropin-releasing hormone agonist (GnRHa) therapy are still controversial.Objective and hypotheses: To longitudinally evaluate the effect of GnRHa therapy on BMI, glycaemic metabolism and lipid profile in children affected by idiopathic central precocious puberty (CPP).Method: This longitudinal retrospective study included data from 42 children (7.70±0.80 years, 2 males) affected b...

hrp0086p2-p779 | Pituitary and Neuroendocrinology P2 | ESPE2016

Central Precocious Puberty in a Female with Gonadal Dysgenesis and Bilateral Gonadoblastoma

Megna Paolo , Scalini Perla , Capirchio Laura , De Martino Maurizio , Losi Stefania , Stagi Stefano

Background: Gonadal dysgenesis may be rarely associated with precocious puberty (PP) and development of gonadoblastoma. In these patients cases of peripheral PP have been reported. On the contrary, a central PP has been very rarely described.Objective and hypotheses: To describe a female with central PP associated with a bilateral gonadoblastoma.Results: A 8 year and 5 month old phenotypically female child, presenting suspected PP ...

hrp0086p2-p835 | Syndromes: Mechanisms and Management P2 | ESPE2016

Turner Syndrome: Does GH Treatment Influence Glucose Homeostasis?

Baronio Federico , Lupi Fiorenzo , Girtler Ylenia , Tamburrino Federica , Maltoni Giulio , Scarano Emanuela , Mazzanti Laura , Radetti Giorgio

Background: Growth hormone (GH) has been shown to reduce insulin sensitivity in Turner girls, however a compensatory increase of insulin secretion by pancreatic beta cells usually occurs, probably stimulated by GH itself. Oral disposition index (ODI) express the capacity of beta cells to adapt to insulin sensitivity.Objective and hypotheses: To study longitudinally the insulin sensitivity (HOMA-S), the insulin secretion (IGI) and the ODI in a group of gi...

hrp0086p2-p836 | Syndromes: Mechanisms and Management P2 | ESPE2016

Renal Anomalies in Children with Turner Syndrome: Experience from a Single-Centre

Lucaccioni Laura , Wong Sze Choong , Strano Rosario , Donaldson Malcolm , Cascio Salvatore , Mason Avril

Background: Renal abnormalities are estimated to be present in 30–40% of Turner Syndrome (TS). Monosomic patients have a reported greater risk for renal anomalies.Objective: To assess the frequency of renal malformations in TS according to karyotype; and report related complications at most recent follow up.Methods: The medical records of 182 patients with TS born between 1970 and 2013 were retrospectively reviewed.<p clas...

hrp0086p2-p854 | Syndromes: Mechanisms and Management P2 | ESPE2016

Growth Pattern, Response to GH Treatment and the Effects of Pubertal Spurt on Final Height in Patients Affected by RASopathies

Tamburrino Federica , Scarano Emanuela , Perri Annamaria , Casto Celeste , Maltoni Giulio , Mazzanti Laura

Background: Reduced growth is a common feature in RASopathies. Poor data are available about pubertal spurt and the effect on final height (FH) in patients with these disorders.Objective and hypotheses: To study growth, body proportions, pubertal pattern, and FH including subject treated with GH-therapy for proven GH deficiency.Method: We analized growth trend and body proportions in 88 patients affected by RASopathies with molecul...

hrp0086p2-p868 | Syndromes: Mechanisms and Management P2 | ESPE2016

Pubertal Development and Final Height in Some Rare Genetic Diseases

Mazzanti Laura , Casto Celeste , Tamburrino Federica , Perri Annamaria , Guidetti Monica , Emanuela Scarano

Background: Pubertal growth, age of puberty onset and pubertal spurt duration are correlated to final height (FH). Few data are available in subjects with rare genetic syndromes.Objective and hypotheses: To evaluate pubertal pattern and its influence on FH in subjects with different genetic syndromes including the effect of GH-therapy for GH deficiency (GHD) and GnRH analogs for precocious puberty (PP).Method: We studied for growth...

hrp0086p2-p936 | Thyroid P2 | ESPE2016

Thyroid Cancer Presentation in Children is Different than in Young Adults

Cannavo Laura , Wasniewska Malgorzata , Zirilli Giuseppina , Violi Maria Antonia , Vermiglio Francesco , De Luca Filippo

Background: Differentiated thyroid cancer (DTC) in pediatric age might have peculiar course and prognosis.Objective and hypotheses: To compare clinical, biochemical and ultrasound (US) features at diagnosis, histological grading and outcome in two groups of children and young adults with DTC.Method: Clinical, biochemical and imaging characteristics of 63 patients with DTC, diagnosed between 1999 and 2014 in our hospital, were retro...

hrp0082fclb5 | Late Breaking Abstracts | ESPE2014

CB2 Polymorphism Could Modulate the Relationship Between Childhood Obesity and Age at Menarche

Grandone Anna , Bellini Giulia , del Giudice emanuele Miraglia , Perrone Laura , Rossi Francesca

Background: There is an emerging evidence that the ovary may be an important site where genes such as LIN28b, whose polymorphisms has been strongly associated to age at menarche, could modulate the timing of puberty. Recent data suggest that the endocannabinoid system plays a role in folliculogenesis and ovulation, through cannabinoid receptor 2 (CB2) expressed in the ovary. On the other hand childhood obesity is associated with increased likelihood of early menarche,...

hrp0082p1-d2-30 | Autoimmune Endocrine Disease | ESPE2014

Managing Children with Thickened Pituitary Stalk and/or Idiopathic Central Diabetes Insipidus: a Single Centre Experience on 63 Children

Cerbone Manuela , Ederies Ash , Losa Laura , Moreno Carolina , Sun Kristi , Spoudeas Helen A

Background and objective: Children with Thickened pituitary stalk (TPS) and/or Idiopathic central diabetes insipidus (ICDI) present to different (endocrine, oncology, and ophthalmology) specialists. Their rarity, absence of agreed radiological criteria or consensus guidance, make their management problematic. Biopsy is too dangerous and cases may remain undiagnosed or evolve over decades. We aimed: i) to longitudinally characterize a large childhood cohort presenting with TPS ...

hrp0082p1-d3-169 | Growth (2) | ESPE2014

Recombinant Human GH Therapy Allows to Reach a Normal Final Adult Height in Coeliac Children with GH Deficiency due to Hypophysistis

Iughetti Lorenzo , Lucaccioni Laura , Bruzzi Patrizia , Di Biase Anna Rita , De Bellis Anna Maira , Predieri Barbara

Background: Coeliac disease (CD) can be associated with impaired growth in children after a prolonged period of Gluten-free diet (GFD). A small percentage of CD patients does not show catch-up growth during GFD because of GH secretion deficiency (GHD) that could be associated with antipituitary autoantibodies (APA).Objective and hypotheses: This study aims to evaluate the efficacy of recombinant human GH (rhGH) therapy on final adult height in children w...