hrp0082p2-d2-427 | Growth Hormone (1) | ESPE2014

Effects and Safety of Recombinant Human GH in GH Deficient Children with Rathke Cyst

Liang Liyang , Zhang Lina , Meng Zhe , Ou Hui , He Zhanwen , Hou Lele , Li Dongfang , Li Pinggan , Luo Xiangyang

Objective: To assess the effects and safety of recombinant human GH (rhGH) in GH deficient (GHD) children with Rathke cyst.Methods: The clinical data of 12 GHD children aged from 5–12 years old, whose radiologic diagnosis showed Rathke cyst during Jan 2010–Dec 2012 in our hospital, were analyzed retrospectively. rhGH was given subcutaneously to each enrolled child with a night dose of 0.1 IU/kg six to seven times a week for 12–30 months. T...

hrp0082p2-d3-610 | Turner Syndrome | ESPE2014

Therapeutic Effects of GH Combined with Low-Dose Stanozolol on Growth Velocity and Final Height of Girls with Turner Syndrome

Chen Hong-Shan , Du Min-Lian , Li Yan-Hong , Xiong Hui , Ma Hua-Mei , Chen Qiu-Li

Objective: This study aimed to investigate the therapeutic effects of recombinant human GH (rhGH) combined with low-dose stanozolol on the growth and final adult height (FAH) of girls with Turner syndrome (TS).Method: A total of 47 girls with TS were treated with rhGH (47.6–52.4 μg/kg per day) and low-dose stanozolol (20–35 μg/kg per day), starting at a mean age of 12.57±1.96 year. The control group consisted of 26 girls with TS,...

hrp0084p2-455 | Growth | ESPE2015

Effect of Aromatase Inhibitor Treatment During Adolescence on the Final Adult Height in Males with Idiopathic Short Stature

Yan-hong Li , Min-lian Du , Hua-mei Ma , Hong-shan Chen , Qiu-li Chen , Jun Zhang

Background: Aromatase inhibitors (AIS) can block the conversion of androgens to estrogens, thus can be used to delay bone maturation in males, however, the effect on improvement of final adult height (FAH) is still controversial.Objective and hypotheses: A prospective study was performed to evaluate the effect of letrozole used on the FAH in males with idiopathic short stature (ISS).Method: 55 boys with ISS and had entered puberty ...

hrp0097fc9.4 | Diabetes and insulin 2 | ESPE2023

The high proportion of INS-MODY in Chinese children with MODY

Ding Yu , Zhang Qianwen , Li Niu , Chang Guoying , Li Juan , Chen Yao , Yao Ru-en , Yu Tingting , Wang Xiumin

Background: The incidence rate of maturity onset diabetes of the young (MODY) and the proportion of different types of MODY will be different in different countries and races. GCK, HNF1A, and HNF4A are the three most common types of MODY, but the occurrence of other rare MODY subtypes in Chinese children is unknown. Therefore, studying the case group of MODY in Chinese children can help deepen understanding of MODY, early identification, and precise treatment....

hrp0098rfc15.2 | Late Breaking | ESPE2024

Study on effects of poly- and perfluoroalkyl substances on hormones in girls with central precocious puberty

Li Yan , Xing Yanan , Yin Xiaoqin , Yang Jiaoru , Zang Shaolian , Dong Ting , Pan Yitao , Dai Jiayin , Li Pin

Background: The pathogenesis of central precocious puberty (CPP) is complex, and exposure to environmental endocrine disruptors leading to CPP deserves attention. Poly- and perfluoroalkyl substances (PFASs) can interfere with sexual development, but there are few reports of their effects on sexual hormones and other hormones in CPP girls.Objective: To explore the levels of PFASs in CPP girls and healthy control girls age...

hrp0092p1-277 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (1) | ESPE2019

New Insights from Unbiased Panel and Whole-Exome Sequencing in a Large Chinese Cohort with Disorders of Sex Development

Xu Yufei , Wang Yirou , Li Niu , Yao Ruen , Li Guoqiang , Li Juan , Ding Yu , Chen Yao , Huang Xiaodong , Chen Yuling , Qing Yanrong , Yu Tingting , Shen Yongnian , Wang Xiumin , Shen Yiping , Wang Jian

Context: Diagnosis of non-chromosomal type disorders of sex development (DSD) has long been challenging. There is still no research on overview of a large Chinese DSD cohort.Objective: To determine the etiologic diagnosis through unbiased large-scale panel sequencing and whole-exome sequencing (WES) within a large Chinese DSD cohort.Design: Patients were recruited according to the ...

hrp0095p1-324 | Growth and Syndromes | ESPE2022

The diagnosis of aortic dilatation in Chinese children and adolescents with Turner syndrome

Wei Su , Longwei Sun , Zhuoguang Li , Xia Liu , Longjiang Zhang , Xiu Zhao , Shumin Fan , Boning Li , Ying Xie , Weiwei Xiao , Zhe Su

Objective: Patients with Turner syndrome (TS) have an increased risk of aortic dilatation (AD), which is associated with higher mortality. The diagnosis of AD in children is more difficult than that in adults. This study aimed to investigate the application of cardiovascular assessment criteria in diagnosing AD in Chinese children and adolescents with TS.Methods: In this retrospective study, a comprehensive cardiovascula...

hrp0095p1-523 | Growth and Syndromes | ESPE2022

The diagnosis of aortic dilatation in Chinese children and adolescents with Turner syndrome

Wei Su , Longwei Sun , Zhuoguang Li , Xia Liu , Longjiang Zhang , Xiu Zhao , Shumin Fan , Boning Li , Ying Xie , Weiwei Xiao , Zhe Su

Objective: Patients with Turner syndrome (TS) have an increased risk of aortic dilatation (AD), which is associated with higher mortality. The diagnosis of AD in children is more difficult than that in adults. This study aimed to investigate the application of cardiovascular assessment criteria in diagnosing AD in Chinese children and adolescents with TS.Methods: In this retrospective study, a comprehensive cardiovascula...

hrp0095p2-229 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

12 years follow-up of GH/PRL secreting pituitary macroadenoma in a child with McCune Albright syndrome

Wei Mei-hua , Li Yan-hong , Xie Liu-lu , Ma Hua-mei , Chen Qiu-li , Chen Hong-shan , Du Min-lian

Background: McCune-Albright Syndrome(MAS)includes fibrous dysplasia(FD), cafe-au-lait spots and gonadotropin-independent precocious puberty(PP). Adenohypophyseal hyperfunction syndromes is uncommon but may be potentially severe complication.Objective: To report a girl who has been confirmed McCune-Albright syndrome and has been found pituitary adenoma during follow-up.Methods:</stron...

hrp0092p1-225 | Growth and Syndromes (to include Turner Syndrome) (1) | ESPE2019

The Phenotypic Spectrum of Kabuki Syndrome in Patients of Chinese Descent

Wang Yirou , Li Niu , Su Zhe , Xu Yufei , Liu Shijian , Chen Yao , Li Xin , Shen Yiping , Wang Jian , Wang Xiumin , Bodamer Olaf

Background: Kabuki syndrome (KS) is a rare dominant disorder of transcriptional regulation with a complex phenotype including cranio-facial dysmorphism, intellectual disability, developmental delay, hypotonia, failure to thrive, short stature and variable cardiac and renal anomalies. Mutations in either KMT2D or KDM6A cause KS. While the phenotype of KS has been reported in many ethnicities, little is known about the phenotypic spectrum of KS...