hrp0095p1-437 | Diabetes and Insulin | ESPE2022

The Relationship between Visceral Adipose Index and Metabolic Syndrome in Children with Type 1 Diabetes Mellitus

Albayrak Serpil , Karaoglan Murat , Keskin Mehmet , Yıldırım Ahmet

Background/Aim: Prediction of metabolic syndrome (Mets) plays important role in cardiovascular disease risk prevention. Although Mets is relatively common in children with T1DM, diagnosis and prediction are ignored. Visceral Adiposity Index VAI) has been defined as a new cardiometabolic risk marker reflecting abdominal fat distribution and dyslipidemia. The aim of the study is to reveal the relationship between Mets and components of VAI in patients with T1DM....

hrp0095p1-326 | Growth and Syndromes | ESPE2022

The relationship of the physical development of erosive gastroesophageal reflux disease in children

Latyshev Dmitry , Lobanov Yuri

The relationship between growth scores and gastroesophageal reflux disease has been extensively studied in the adult population. Single studies conducted in childrenObjective: To study the relationship between anthropometric parameters and erosive gastroesophageal reflux disease in school-age childrenMaterials and methods: 103 children with erosive GERD were included (65 boys, mean age 12.3±2.5 ...

hrp0095p1-329 | Growth and Syndromes | ESPE2022

Associations between Eating Patterns of Adolescents and Their Height and Weight, A Comparison Between Genders

Zur Maya , Fisch-Shvalb Naama , Phillip Moshe , Yackobovitch-Gavan Michal

Rationale: Adequate nutrition is essential for normal growth in childhood and adolescence. The high growth rate during adolescence demands high amounts of energy and various nutrients. During puberty, unlike infancy and early childhood, boys and girls of the same age have gender-specific nutritional needs. Our aim was to examine the associations between the dietary intake of male and female adolescents and their anthropometric measures.<...

hrp0095p1-508 | Growth and Syndromes | ESPE2022

Real-world experience with Vosoritide for achondroplasia: interim findings from an early access programme in France

Cormier-Daire Valérie , Cohen Shelda , Edouard Thomas , Isidor Bertrand , Mukherjee Swati , Pimenta Jeanne , Rossi Massimiliano , Schaefer Elise , Sigaudy Sabine , Baujat Geneviève

Introduction: Achondroplasia is caused by a pathogenic mutation in the FGFR3 gene, leading to impaired endochondral bone growth and multiple medical complications. Vosoritide (once daily, subcutaneous injection) has recently been approved by the European Medicines Agency (EMA) for treating achondroplasia in patients aged ≥2 years until closure of epiphyses. It has been made available in France via an early access program, a cohort Temporary Authorization fo...

hrp0095p1-512 | Growth and Syndromes | ESPE2022

Physical Activity: An Underestimated Factor in the Management of Arterial Hypertension in Women with Turner-Syndrome?

Sebastian Oberhoffer Felix , Bačová Martina , Li Pengzhu , Arnold Leonie , Alexander Haas Nikolaus , Dalla-Pozza Robert

Introduction: Turner syndrome (TS) is a rare X-chromosomal disease, which affects one in 2500-3000 female newborns. TS is associated with a distinct cardiovascular morbidity and mortality. Arterial hypertension is present in up to 50% of young TS women and closely related to the onset of aortic dilatation and dissection. The effective management of arterial hypertension can be considered as crucial to improve overall cardiovascular outcome of TS women. In the ...

hrp0095p1-387 | Thyroid | ESPE2022

Pediatric Graves Disease (PGD): presentation, treatment and follow up. A single center Argentine perspective

Rothenfusser Anna , Eugenia Masnata Maria , Suco Valle Sofia , Eugenia Rodriguez Maria , Bergada Ignacio , Papendieck Patricia , Elena Chiesa Ana

Introduction: PGD is characterized by hyperthyroidism and antibodies against the TSH receptor (TSHRAB). Reported annual incidence is 4,58/100,000.Objective: To describe an Argentinean cohort with PGD followed between 2006 and 2020 at the Ricardo Gutierrez Children’s Hospital.Material and Methods: Retrospective study of 69 patients, who were treated initially with antithyroid ...

hrp0095p1-399 | Thyroid | ESPE2022

Evaluation of Childhood Thyroid Nodules: A Single Center Experience

Öner Ganimet , Bideci Aysun , Nalçacı Sinem , Orhun Çamurdan Mahmut , Döğer Esra , Cinaz Peyami

Introduction: Although thyroid nodule is seen less frequently in childhood than in adults, it is more likely to be malignant. The aim of this study was to examine the characteristics of the patients followed up for thyroid nodules and to define the patients with malignant potential by laboratory, radiological and cytological evaluations.Method: 100 patients (F/M:63/37) with thyroid nodules followed up in Pediatric Endocr...

hrp0097rfc4.5 | Growth and syndromes (to include Turner syndrome) | ESPE2023

Real-world safety and effectiveness of vosoritide: Results from an early access program in France

Cormier-Daire Valérie , Edouard Thomas , Isidor Bertrand , Cohen Shelda , Mukherjee Swati , Pimenta Jeanne , Lhaneche Leila , Rossi Massimiliano , Schaefer Elise , Goodman Erin , Sigaudy Sabine , Baujat Geneviève

Introduction: Achondroplasia is the most common skeletal dysplasia, in which the main clinical feature is short stature. Vosoritide, the first specific treatment for achondroplasia; administered as a daily subcutaneous injection, was approved by the European Medicines Agency in August 2021 for patients aged ≥2 years until closure of epiphyses. French Health Authorities granted early access to vosoritide treatment in France on 24 June 2021, which continued u...

hrp0097rfc6.4 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Earlier Occurrence of Puberty and Pubertal Hair Development in Boys and Girls - Insights from the DPV Initiative Data

Reschke Felix , Gohlke Bettina , Lanzinger Stefanie , Boettcher Claudia , Gemulla Gita , Thiele-Schmitz Susanne , Dunstheimer Desiree , van den Boom Louise , Joachim Woelfle , Reinhard Holl

Introduction: Pubertal onset is signaled by thelarche (in girls) and gonadarche (in boys) and indicates the beginning of the hypothalamic-pituitary-gonadal axis activity. Thus, the onset of pubic hair development usually coincides with adrenarche. Girls worldwide are experiencing earlier puberty, but it is uncertain if this trend affects boys, or if it applies to children with type 1 diabetes (T1D).Aim: The aim of this s...

hrp0097p1-229 | Diabetes and Insulin | ESPE2023

Trajectories of glycemic control in transition-aged patients with type 1 diabetes

Jee Kim Min , Jeong Lee Yun , Ho Shin Choong , Ah Lee Young

Objectives: We investigated the trajectories in hemoglobin A1C (A1C) levels among transition-aged patients (age from 15 to 22 years) with type 1 diabetes (T1D).Methods: Among the patients diagnosed with type 1 diabetes in pediatric age between 2001 and 2013 in Seoul National University Children’s Hospital, 119 patients (54 males and 65 females) with a diagnostic age for under 14 and measurement of A1C at least once...