hrp0095p1-486 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2022

Salivary Sex Steroid Levels in Infants During Minipuberty and Their Relationship with Infantile Colic

Mete Fulya , Gürsoy Çalan Özlem , Mert Erbaş İbrahim , Tolga İnce Osman , Neslişah Tan Makbule , Aydın Adem , Abacı Ayhan , Böber Ece , Demir Korcan

Background: The etiology of infantile colic is unknown. Its timing overlaps with that of minipuberty. To the best of our knowledge, the relationship between these entities has not been investigated. In this study, we aimed to assess the relationship between minipuberty and infantile colic by measuring the levels of sex steroids in saliva among infants with and without infantile colic.Methods: Saliva samples were collecte...

hrp0084p1-128 | Thyroid | ESPE2015

Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor α Mutations

Demir Korcan , van Gucht Anja , Buyukinan Muammer , Catli Gonul , Ayhan Yavuz , Bas Veysel Nijat , Dundar Bumin Nuri , Ozkan Behzat , Meima Marcel E , Visser W Edward , Peeters Robin P , Visser Theo J

Background: Recently, T3 receptor alpha (TRα) mutations have been identified in a number of patients with varying degrees of growth impairment, delayed development, constipation, increases in serum T3 and decreases in T4 and rT3.Objective: To determine the spectrum of clinical and functional consequences of novel TRα mutations.Method: Clinical assessment and biochemical, imaging...

hrp0084p3-642 | Bone | ESPE2015

Comparison of Treatment Alternatives for Hypercalcemia due to Vitamin D Intoxication in Children

Demir Korcan , Doneray Hakan , Yesilkaya Ediz , Kara Cengiz , Atay Zeynep , Cetinkaya Semra , Cayir Atilla , Anik Ahmet , Eren Erdal , Demirel Fatma , Yilmaz Gulay Can , Ergur Ayca Torel , Kendirci Mustafa , Aycan Zehra , Bereket Abdullah , Aydin Murat , Orbak Zerrin , Ozkan Behzat

Background: No large study comparing efficiency of prednisolone, alendronate and pamidronate has been conducted so far in children with hypercalcemia due to vitamin D intoxication.Objective and hypotheses: To perform a multicentre, retrospective study assessing clinical characteristics and treatment results.Method: A standard questionnaire was uploaded to an online national database system (www.favorsci.org) to collect data of chil...

hrp0097rfc6.2 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Psychosocial Evaluation of Girls with Rapidly Progressive Puberty Presenting with Early Menarche

Yüksek Acinikli Kübra , Besci Ozge , Akın Kağızmanlı Gözde , Gündoğan Nazan , Unutmaz Güldal , Berkay Esen Ahmet , Alşen Güney Sevay , Korcan Demir Korcan , Böber Ece , Abacı Ayhan

Key words: early puberty, mood change, GnRH analogueIntroduction-Aim: In cases with early puberty, neuroendocrine, physical, and psychological changes are considered to result in several mood disorders. The aim of this research was to assess the mental problems of pubertal girls with rapidly progressive puberty (RPP) with menarche before the 10 years of age. To the best of our knowledge, there is no similar prospective c...

hrp0097p1-123 | Growth and Syndromes | ESPE2023

Aromatase Inhibitors May Increase the Risk of Cardiometabolic Complications in Adolescent Boys

Besci Özge , Damla Akçura Yağmur , Yüksek Acinikli Kübra , Akın Kağızmanlı Gözde , Demir Korcan , Böber Ece , Kır Mustafa , Abacı Ayhan

Introduction: Aromatase inhibitors (AIs) are increasingly used in children and adolescents to augment adult height. Given the potential risks of these drugs in women with breast cancer, detailed cardiovascular examinations in adolescents using these treatments are needed to ensure their safety in the pediatric group. The aim of this study was to investigate the effects AIs on cardiac morphology, functions and their relation to several metabolic parameters in a...

hrp0097p1-315 | Growth and Syndromes | ESPE2023

Which Method is More Effective in Predicting Adult Height in Pubertal Girls Treated with Gonadotropin-Releasing Hormone Agonist?

Akın Kağızmanlı Gözde , Deveci Sevim Reyhan , Besci Özge , Yüksek Acinikli Kübra , Hazal Buran Ayşen , Mert Erbaş İbrahim , Böber Ece , Demir Korcan , Anık Ahmet , Abacı Ayhan

Purpose: The aim of the present study was to determine the efficiency of three different predictive models [Bayley-Pinneau (BP), Roche-Wainer-Thissen (RWT), and Tanner-Whitehouse 2 (TW2)] by comparing their predictions with near-adult height (NAH) data of girls who received gonadotropin-releasing hormone agonist (GnRHa) therapy.Methods: Clinical findings were retrospectively analyzed. Bone age (BA) was determined by thre...

hrp0098fc1.3 | Diabetes and Insulin | ESPE2024

A Non-Invasive Diagnostic Tool for Early Detection of Microvascular Alterations in Children with Type 1 Diabetes Mellitus: Nail-Fold Capillaroscopy

Akın Kağızmanlı Gözde , Aydın Tuncay , Yüksek Acinikli Kübra , İşgüder Rana , Kızıldağ Karabacak Zehra , Demir Korcan , Böber Ece , Erbil Ünsal Şevket , Abacı Ayhan

Background: Nail-fold capillaroscopy (NFC), a non-invasive tool that can detect microvascular changes, has recently gained popularity in the diabetes field as a warning sign before the development of diabetes-related complications.Objective: We aimed to assess capillary microarchitecture in children with type 1 diabetes mellitus (T1DM) by comparing them with a healthy control group.Subjects...

hrp0098p1-177 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

Androgen Receptor Cag Repeat Polymorphism Might Be A Possible Cause of Familial Constitutional Delay in Growth and Puberty

Akın Kağızmanlı Gözde , Deveci Sevim Reyhan , Manyas Hayrullah , Paketçi Ahu , Demir Korcan , Böber Ece , Çatlı Gönül , Anık Ahmet , Abacı Ayhan

Background: Being able to induce puberty through a short course of low-dose testosterone therapy in boys with constitutional delay of growth and puberty (CDGP) indicates a crucial interaction between testosterone and androgen receptor (AR) during the activation and maturation of the hypothalamic-pituitary-gonadal axis at the onset of puberty. Previous studies have indicated an inverse association between the CAG repeat length and the transactivation function o...

hrp0098p2-285 | Thyroid | ESPE2024

Levothyroxine poisoning in children is usually benign: A multi-center experience from Turkey

Şen Küçük Kübra , Demir Şule , Deveci Sevim Reyhan , Akgül Fatma , Yalçın Gülşen , Eser Öznur , Bal Alkan , Ergün Elif , Öztürk Sercan , Anık Ahmet

Objective: The objective of this study was to investigate the clinical presentations, laboratory findings, treatment modalities, follow-up strategies employed for children with levothyroxine (LT4) poisoning.Materials-Methods: The study encompassed patients admitted to the respective centers between 2010-2023, who fulfilled the predefined study criteria. Findings were presented as percentages (%), median values with inter...

hrp0098p3-77 | Diabetes and Insulin | ESPE2024

Modified Diabetic Ketoacidosis Protocol - 12-Year Treatment Experience

Özalp Kızılay Deniz , Derin Aydın Ece , Selçuk Özkan Hasan , Şafaklı Aykut , Demir Günay , Özen Samim , Darcan Şükran , Gökşen Damla

Aim: The ideal intravenous (iv) fluid administration rate in the treatment of diabetic ketoacidosis (DKA) and its effect on metabolic normalization, changes in electrolyte levels and the development of complications such as cerebral oedema are controversial in the paediatric age group. We aimto present the results of a practical and modified DKA treatment protocol, which was prepared with reference to the International Society for Paediatric and Adolescent Dia...