hrp0095fc11.4 | Late Breaking | ESPE2022

CRN04777, an oral, nonpeptide selective SST5 receptor agonist, dose-dependently suppresses both fasting and stimulated insulin secretion: results from a first in human study

Ferrara-Cook Christine , Luo Rosa , De la Torre Eduardo , Wang Yang , Betz Stephen , Lagast Hjalmar , Struthers Scott , Hovelmann Ultike , Heise Tim , Krasner Alan

Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in neonates, infants, and children, and is caused by genetic mutations in pancreatic beta-cells. Current therapies are burdensome, have limited efficacy, and are associated with significant morbidity. CRN04777 is a potent, orally-bioavailable, selective SST5 agonist that suppresses insulin secretion in the terminal steps of the insulin secretion pathway and could be useful for patients with con...

hrp0092t10 | Top 20 Poster | ESPE2019

Changes in Adrenal Androgens and Steroidogenic Enzyme Activities in Children Aged 2, 4, and 6 Years: Steroid Hormone Profiling From the Prospective Cohort Study

Hyun Kim Jae , Ah Lee Young , Ho Shin Choong , Yang Sei Won , Song Junghan , Lim Youn-Hee , Kim Bung-Nyun , Inhyang Kim Johanna , Hong Yun-Chul

Introduction: Adrenarche refers to the increase in adrenal androgen synthesis. However, process of adrenal androgen production in early childhood remains to be elucidated. The aim of this study was to evaluate changes in adrenal androgen levels and steroidogenic enzyme activities associated with adrenarche using a prospective cohort.Methods: A total of 229 children (124 boys, 52.4%), who had participated in the Envir...

hrp0092lb-21 | Late Breaking Posters | ESPE2019

How Can the Occurrence of Delayed Elevation of Thyroid Stimulating Hormone in Preterm Infants Born Between 35 and 36 Weeks Gestation be Predicted?

Jung Heo You , Ah Lee Young , Jeong Lee Yun , Hee Lim Youn , Rim Chung Hye , Han Shin Seung , Ho Shin Choong , Won Yang Sei

Objective: We evaluated frequency and risk factors of delayed TSH elevation (dTSH) and investigated follow-up outcomes in the dTSH group with venous TSH (v-TSH) levels of 6–20 mU/L according to whether late preterm infants born at gestational age (GA) 35–36 weeks had risk factors.Methods: The medical records of 810 neonates (414 boys) born at Seoul National University Hospital who had a normal neonatal screenin...

hrp0092p3-145 | GH and IGFs | ESPE2019

Final Adult Height of Children with Idiopathic Short Stature: A Multicenter Study on GH Therapy Alone Started During Peripuberty

Wu Di , Chen Rui-min , Chen Shao-ke , Liu Ge-li , Chen Lin-qi , Yang Yu , Wang Xin-li , Peng Ya-guang , Gong Chun-xiu

Purpose: To evaluate the efficacy of GH in improving FAH in ISS children in a multicenter study.Methods: A real-world observation was carried out. Children with ISS in seven hospitals in China were enrolled. The height gain standard deviation score and the height gain over the target height were evaluated.Results: There were 344 ISS patients (217 boys and 127 girls). The baseline a...

hrp0089p1-p107 | Fat, Metabolism and Obesity P1 | ESPE2018

Serum Uric Acid Level and Its Association with Metabolic Syndrome in Korean Adolescents

Jung So Yoon , Lee Young Ah , Kim Jae Hyun , Lee Seong Yong , Kim Se Young , Shin Choong Ho , Yang Sei Won

Background: Elevated serum uric acid (UA) levels are associated with metabolic syndrome (MS), cardiometabolic risk factors (CMRFs) and non-alcoholic fatty liver disease (NAFLD) in adults. However, little is known about usefulness of UA to predict MS in adolescents. As the prevalence of obesity among pediatric population has been increasing, it is important to know the factors associated with the CMRFs to prevent future development of diabetes and cardiovascular disease.<p ...

hrp0089p2-p338 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Physical Assessment in Chinese Children with 5a-reductase Type 2 Deficiency

Zhao Xiu , Song Yanning , Chen Shaoke , Wang Xiumin , Luo Feihong , Yang Yu , Chen Linqi , Chen Ruimin , Chen Hui , Su Zhe , Wu Di , Gong Chunxiu

Background: 5α - reductase type 2 deficiency (5αRD) is an autosomal recessive hereditary disease which has an incidence of 11.2%–15.5% among population with 46, XY DSD (disorders of sex development).Objective: To study the growth pattern in Chinese pediatric patients with 5αRD.Subjects: Data were from 187 patients with 5αRD (age from 0–16 years old,with homozygous or compound heterozygous mutations in ...

hrp0089p1-p262 | Thyroid P1 | ESPE2018

Subclinical Hypothyroidism, Thyroid Nodule or Cyst in Prepubertal Children: How Many Children were Diagnosed at Age 6?

Lee Young Ah , Cho Sun Wook , Lim Youn-Hee , Kim Johanna Inhyang , Kim Bung-Nyun , Hong Yun-Chul , Park Young Joo , Shin Choong Ho , Yang Sei Won

Purpose: We investigated the prevalence of subclinical hypothyroidism (SCH) and its risk factors in prepubertal children at age 6. We also evaluated the prevalence of thyroid nodule or cyst and its relationship with SCH in prepubertal children.Methods: From the Environment and Development of Children (EDC) cohort study, 458 prepubertal children (243 boys, mean 5.8 years) who visited at age 6 were included in this study. Serum concentrations of free thyro...

hrp0089lb-p13 | Late Breaking P1 | ESPE2018

Clinical and Endocrine Characteristics and Genetic Analysis of Korean Children with McCune–Albright Syndrome

Cho Eun-Kyung , Im Minji , Kim Jinsup , Yang Aram , Song Ari , Ki Chang-Seok , Lee Ji-Eun , Cho Sung Yoon , Jin Dong-Kyu

McCune-Albright syndrome (MAS) is a rare disease defined by the triad of precocious puberty (PP), café au lait spots, and fibrous dysplasia (FD). There are only a few patients with MAS in Korean because of the rarity of this disease. We reported the various clinical and endocrine manifestations and genetic analysis of 14 patients with MAS in Korea. It is a retrospective cohort study of patients’ clinical data including about peripheral PP, FD. Also, treatment experie...

hrp0084p1-29 | Diabetes | ESPE2015

Is Reduced Heart Rate Variability Associated with Arterial Stiffness in Youth with Childhood-Onset Type 1 Diabetes Mellitus?

Kim Hwa Young , Jung Hae Woon , Lee Gyung Min , Kim So Youn , Jeong Kyung A , Choi Keun Hee , Lee Jieun , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: Increased arterial stiffness may precede cardiovascular complications in patients with type 1 diabetes (T1DM). As the autonomic nervous system is responsible for regulating heart rate and vascular tone, autonomic dysfunction may contribute to increased arterial stiffness in patients with T1DM.Objective and hypotheses: We investigated whether decreased heart rate variability (HRV) was associated arterial stiffness index (ASI) in patients with ...

hrp0084p1-139 | Turner &amp; Puberty | ESPE2015

A Study of Arterial Stiffness in Turner Syndrome Patients Using Cardio-Ankle Vascular Index

Jung Hae Woon , Kim Hwa Young , Lee Gyung Min , Kim So Youn , Jeong Kyung A , Choi Keun Hee , Lee Jieun , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: A large proportion of the increased mortality in Turner syndrome (TS) is related to cardiovascular complications. Increased arterial stiffness may be an important predictor related to cardiovascular complications. A novel method of evaluating arterial stiffness, relatively independent of changes in blood pressure (BP), is the cardio-ankle vascular index (CAVI).Objective and hypotheses: The aim of this study was to compare arterial stiffness u...