hrp0084p2-521 | Puberty | ESPE2015

A Novel Entity Characterised by GH Deficiency and Central Precocious Puberty in Two Siblings and their Father, in the Absence of Central Nervous System Defect

Voutetakis Antonis , Chiotis Dimitris , Dracopoulou-Vabouli Maria , Magiakou Alexandra-Maria , Chrousos Georgia , Chrousos George , Dacou-Voutetakis Catherine

Background: The association of GH deficiency (GHD) with central precocious puberty (CPP) has been reported in individuals with central nervous system (CNS) abnormalities, congenital or acquired. Co-existence of GHD and CPP has been rarely reported, always as an isolated, sporadic disorder.Objective and hypotheses: To present the familial occurrence of combined GHD and CPP.Method: GH was measured post L DOPA, glucagon and GHRH and g...

hrp0084p3-604 | Adrenals | ESPE2015

Severe High Blood Pressure with Renal Failure in a Neglected Case of 11β-Hydroxylase Deficient Congenital Adrenal Hyperplasia

Belceanu Alina Daniela , Munteanu Mihaela , Florea Mariana , Ungureanu Maria-Christina , Zmau George , Puiu Mirela , Armasu Ioana , Mogos Voichita , Vulpoi Carmen

Background: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterised by impaired cortisol synthesis. An enzymatic defect in 11-beta-hydroxylase is the second most common variant of CAH and accounts for approximately 5–8% of cases. Patients present with features of androgen excess and approximately two thirds of patients also have high blood pressure (HBP), which is initially responsive to glucocorticoid replacement, but may become a c...

hrp0084p3-959 | GH & IGF | ESPE2015

Late Diagnosis of a Type II/III Mucolipidoses Treated with GH Replacement Therapy

Crumpei Iulia , Belceanu Alina , Armasu Ioana , Braha Elena , Rusu Cristina , Manolachie Adina , George Zmau , Preda Cristina , Vulpoi Carmen

Background: Mucolipidoses II/III (ML) are rare autosomal recessive lysosomal storage disorders (incidence: 1/325 000 live births). They have overlapping clinical phenotypes with mucopolysaccharidosis disorders and include growth retardation, facial dysmorphism, skeletal abnormalities, respiratory and heart diseases, hepatosplenomegaly and abdominal hernias. There is no specific treatment and the management has been limited to supportive care.Case present...

hrp0094p1-92 | Thyroid A | ESPE2021

Emotional Intelligence scores in children and adolescents with subclinical hypothyroidism - correlation with serum serotonin and thyroid stimulating hormone (TSH) concentrations.

Kostopoulou Eirini , Arianas George , Ioannidis Anastasios , Dimopoulos Ioannis , Chiotis Christos , Prezerakos Panagiotis , Spiliotis Bessie , Rojas Gil Andrea Paola ,

Introduction: Thyroxine is important for nervous system development. Subclinical hypothyroidism (SCH), a mild thyroid dysfunction, is associated with impaired cognitive function in children and mood disorders in adults. Serotonin is also involved in brain development, mood and behavior modulation. The possible interaction between thyroid function tests, serum serotonin concentrations and emotional intelligence, was studied.Method...

hrp0094p1-103 | Adrenal B | ESPE2021

Leukocyte telomere length in children with Congenital Adrenal Hyperplasia

Raftopoulou Christina , Abawi Ozair , Sommer Grit , Binou Maria , Paltoglou George , Fluck Christa , Akker Erica van den , Charmandari Evangelia ,

Introduction: Exposure to chronic stress and hypercortisolism is associated with decreased leukocyte telomere length (LTL), a marker for accelerated biological aging and cardiovascular disease. Children with congenital adrenal hyperplasia (CAH) are treated with glucocorticoids. The aim of our study was to investigate LTL in children with CAH and its relation with CAH subtype, daily glucocorticoid dose and treatment quality.Method...

hrp0098fc1.2 | Diabetes and Insulin | ESPE2024

Effect of hydroxychloroquine therapy in newly diagnosed type 1 diabetes: a randomised, double-blind, placebo-control pilot trial

George Arun , Kumar Rakesh , Patil Amol , Sachdeva Naresh , Yadav Jaivinder , Jacob Neenu , Banerjee Sayan , Nanda Pamali , Bala Anju

Background: Hydroxychloroquine sulfate (HCQS) is an immunomodulatory drug used to treat various rheumatological conditions. However, its effect on preserving β-cell function in type 1 diabetes remains unclear.Objective: To determine the differences in C-peptide (fasting and post mixed meal) and HbA1c in children with new-onset T1D on hydroxychloroquine therapy versus placebo.Methods:</...

hrp0098p1-25 | Diabetes and Insulin 1 | ESPE2024

Assessment of small nerve fiber function as an early marker of peripheral neuropathy in children and adolescents with type 1 diabetes mellitus (T1DM)

Kokotis Panagiotis , Paltoglou George , Argyropoulou Stavroula , Bountziouka Chrysanthi , Karamatzianni Georgia , Karanasios Spyridon , Sakou Irini-Ikbale , Karavanaki Kyriaki

Introduction: Peripheral diabetic neuropathy (PDN), clinical or subclinical, of large-diameter nerve fibers or small-diameter nerve fibers is a common complication of type 1 diabetes mellitus (T1DM).Aims: Early detection of the prevalence of subclinical PDN by assessing the function of small and large nerve fibers in children and adolescents with T1DM.Methods: The study included 53...

hrp0098p1-127 | Diabetes and Insulin 3 | ESPE2024

Molecular Characterization, Clinical phenotype and Long-Term Outcomes in Neonatal Diabetes Mellitus: nearly two decades of experience in a tertiary care pediatric diabetes clinic in north India

Kumar Rakesh , Dayal Devi , George Arun , Banerjee Sayan , Yadav Jaivinder , Bala Anju , Nanda Pamali , Evans Molly , Mohan Vishwanathan , Venkateshan Radha

Background: Neonatal diabetes mellitus (NDM) is a rare monogenic disorder that typically occurs within the first 6 months of life. However, there is limited information from India about the clinical characteristics, treatment, and long-term outcomes for children with NDM. This study aims to provide a comprehensive overview of one of India's largest cohorts of children with NDM. These children were treated at a single referral center in North India over a ...

hrp0098p1-181 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

Characterization of puberty-regulating microRNAs within the hypothalamus of female mice

Fanis Pavlos , Morrou Maria , Tomazou Marios , Abdulgadr M. Alghol Hend , M Spyrou George , Neocleous Vassos , A Phylactou Leonidas

Background: Puberty is a crucial developmental stage marked by the transition from childhood to adulthood, organized by complex hormonal signaling within the neuroendocrine system. The hypothalamus, a central region in this system, regulates pubertal functions through the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-releasing hormone (GnRH) neurons, essential in puberty control, release GnRH in a pulsatile manner, initiating the production of sex ho...

hrp0098p2-97 | Fat, Metabolism and Obesity | ESPE2024

Improvement of Cardiometabolic Risk Factors and Psychosocial Health in Children and Adolescents with Excess Adiposity following Implementation of a Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program

Vourdoumpa Aikaterini , Paltoglou George , Koutaki Diamanto , Kassari Penio , Manou Maria , Papadopoulou Marina , Bacopoulou Flora , Kolaitis Gerasimos , Charmandari Evangelia

Introduction: Childhood obesity has reached epidemic proportions in contemporary societies with multiple comorbidities. Social stigma, low self-esteem, depression, anxiety, and behavioral problems are noted in youth with excess adiposity, and may persist for a long time. The aim of our study was to assess the alterations in cardiometabolic risk factors and mental health in children and adolescents with excess adiposity following the implementation of a multidi...