hrp0098p1-25 | Diabetes and Insulin 1 | ESPE2024

Assessment of small nerve fiber function as an early marker of peripheral neuropathy in children and adolescents with type 1 diabetes mellitus (T1DM)

Kokotis Panagiotis , Paltoglou George , Argyropoulou Stavroula , Bountziouka Chrysanthi , Karamatzianni Georgia , Karanasios Spyridon , Sakou Irini-Ikbale , Karavanaki Kyriaki

Introduction: Peripheral diabetic neuropathy (PDN), clinical or subclinical, of large-diameter nerve fibers or small-diameter nerve fibers is a common complication of type 1 diabetes mellitus (T1DM).Aims: Early detection of the prevalence of subclinical PDN by assessing the function of small and large nerve fibers in children and adolescents with T1DM.Methods: The study included 53...

hrp0098p1-181 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

Characterization of puberty-regulating microRNAs within the hypothalamus of female mice

Fanis Pavlos , Morrou Maria , Tomazou Marios , Abdulgadr M. Alghol Hend , M Spyrou George , Neocleous Vassos , A Phylactou Leonidas

Background: Puberty is a crucial developmental stage marked by the transition from childhood to adulthood, organized by complex hormonal signaling within the neuroendocrine system. The hypothalamus, a central region in this system, regulates pubertal functions through the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-releasing hormone (GnRH) neurons, essential in puberty control, release GnRH in a pulsatile manner, initiating the production of sex ho...

hrp0098p2-97 | Fat, Metabolism and Obesity | ESPE2024

Improvement of Cardiometabolic Risk Factors and Psychosocial Health in Children and Adolescents with Excess Adiposity following Implementation of a Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program

Vourdoumpa Aikaterini , Paltoglou George , Koutaki Diamanto , Kassari Penio , Manou Maria , Papadopoulou Marina , Bacopoulou Flora , Kolaitis Gerasimos , Charmandari Evangelia

Introduction: Childhood obesity has reached epidemic proportions in contemporary societies with multiple comorbidities. Social stigma, low self-esteem, depression, anxiety, and behavioral problems are noted in youth with excess adiposity, and may persist for a long time. The aim of our study was to assess the alterations in cardiometabolic risk factors and mental health in children and adolescents with excess adiposity following the implementation of a multidi...

hrp0098p2-190 | Growth and Syndromes | ESPE2024

Rare Cases of Primary Hypoparathyroidism in Childhood in the Covid-19 Era

Vourdoumpa Aikaterini , Plessa Theodora , Paltoglou George , Amountza Georgia , Oikonomou Stavroula , N Maritsi Despoina , Soldatou Alexandra , N Tsolia Maria , Karavanaki Kyriaki

Introduction: Primary hypoparathyroidism is a rare cause of hypocalcemia, complicating various disorders. Clinical presentation ranges from asymptomatic patients to paresthesia, cramps, seizures, stridor, laryngospasm, cardiac arrhythmias, basal ganglia calcification, subcapsular cataracts, and dental enamel hypoplasia. This study aims to present the cases of two patients with rare causes of primary hypoparathyroidism and highlight the need for standardization...

hrp0098p2-313 | Late Breaking | ESPE2024

Correlation of Bone Health Index (BHI) and Metacarpal Index (MCI) with calcium metabolism parameters in children and adolescents

Ntova Maria , Chrysis Dionysios , Dermitzaki Eleni , N Michoula Aspasia , Christopoulos Panayiotis , Mastorakos George , N Grivea Ioanna , T Papadimitriou Dimitrios

Introduction: The assessment of bone maturation with artificial intelligence (AI) has introduced new straightforward indicators of bone health monitoring related the much more complex and expensive method of measuring bone density with DEXA (Dual-Energy X-Ray Absorptiometry). Bone Health Index (BHI) describes bone mass as a function of cortical thickness, width and length of the three middle metacarpals, using digital hand X-rays for bone age evaluation from D...

hrp0098p2-314 | Late Breaking | ESPE2024

Bone Health Index (BHI) and Metacarpal Index (MCI) in boys and girls on treatment with aromatase inhibitors

Piperidou Alexandra , Chrysis Dionysios , Dermitzaki Eleni , N Michoula Aspasia , Christopoulos Panayiotis , Mastorakos George , N Grivea Ioanna , T Papadimitriou Dimitrios

Third generation AIs have been repurposed as an off-label treatment in boys and girls, as they can retard closure of the epiphysial plate expanding the period of growth. Assessment of digital hand X-rays has introduced new follow-up indexes of bone health: Bone Health Index (BHI) from DICOM files describes bone mass as a function of cortical thickness, and Metacarpal Index (MCI) from digitized files expresses the cortical thickness standardized for the outer bone diameter at t...

hrp0098p2-393 | Late Breaking | ESPE2024

Transcriptomic analysis of peripheral blood mononuclear cells reveals immune and metabolic pathways associated with both puberty-blockade and gender-affirming sex hormone therapy in young transgender individuals

Cross Heather , Peckham Hannah , Peng Junjie , Radziszewska Ania , Butler Gary , Jury Elizabeth , Rosser Elizabeth , A Robinson George , Ciurtin Coziana

Introduction: Sex differences associated with inflammation have been observed across numerous autoimmune and cardiometabolic conditions. We aim ed to explore the differential impact of sex hormones/sex chromosomes on molecular pathways potentially relevant for immune cell functions using a unique post-pubertal transgender cohort.Methods: RNA-sequencing was performed on peripheral blood mononuclear cells (PBMCs) from a he...

hrp0098p3-284 | Late Breaking | ESPE2024

Dramatic deterioration of subclinical hyperparathyroidism in children and adolescents during the post-COVID-19 period

Loutsou Maria , Dermitzaki Eleni , Christopoulos Panayiotis , N Michoula Aspasia , Mastorakos George , Diamantopoulos Stavros , N Grivea Ioanna , T Papadimitriou Dimitrios

Vitamin D is a steroid hormone, essential for the immune system and bone health. Given that sun exposure is meant to provide at least 80% of daily vitamin D requirements, the COVID-19 pandemic is likely to have a considerable influence on calcium metabolism We retrieved anonymized data on calcium metabolism parameters assessing the occurrence of subclinical hyperparathyroidism – subclinical nutritional rickets (PTH ≥ 45 pg/ml with normal serum Ca ≤ 10.5 mg/dl) in c...

hrp0098p1-43 | Fat, Metabolism and Obesity 1 | ESPE2024

BIO-STREAMS: Multi-Pillar Framework for children Anti-Obesity Behavior building on an EU biobank, Micro Moments and Mobile Recommendation Systems

Kassari Penio , Genitsaridi Sofia-Maria , Ramouzi Eleni , Giannopoulou Eleni , Kokkou Eleni , Papadopoulou Marina , Koutaki Diamanto , Stefanou Garyfallia , Nikitas Christos , Bibas Athanasios , Prasinos Marios , Brisimi Theodora , Pitoglou Stavros , Georga Eleni , Mlakar Ιzidor , Kontogianni Meropi , Matsopoulos George , Koutsouris Dimitris , Charmandari Evangelia , behalf of BIO-STREAMS Consortium on

Introduction: The World Health Organization (WHO) European Regional Obesity Report 2022 stated that obesity rates have reached epidemic proportions across the European Union (EU). Obesity affects nearly one in three children (29% of boys and 27% of girls), and is associated with adverse psychological and psychosocial outcome and increased risk for noncommunicable diseases (NCDs). In addition, none of the 53 Member States are on track to meet the target of stop...

hrp0095p1-358 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Pathogenic and Low-Frequency genetic determinants in children with Central Precocious Puberty

Fanis Pavlos , Toumba Meropi , A Tanteles George , Iasonides Michalis , C Nicolaides Nicolas , Nicolaou Stella , Kyriakou Andreas , Neocleous Vassos , A Phylactou Leonidas , Skordis Nicos

Background: Central precocious puberty (CPP) due to premature activation of GnRH secretion results in early epiphyseal fusion and to a significant compromise in the achieved final adult height as well as psychological consequences. So far only a limited number of genetic determinants have been associated with the pathogenesis in children with CPP. In this original research, rare sequence variants in MKRN3, DLK1, KISS1, and KISS1R genes were i...