hrp0098p2-190 | Growth and Syndromes | ESPE2024

Rare Cases of Primary Hypoparathyroidism in Childhood in the Covid-19 Era

Vourdoumpa Aikaterini , Plessa Theodora , Paltoglou George , Amountza Georgia , Oikonomou Stavroula , N Maritsi Despoina , Soldatou Alexandra , N Tsolia Maria , Karavanaki Kyriaki

Introduction: Primary hypoparathyroidism is a rare cause of hypocalcemia, complicating various disorders. Clinical presentation ranges from asymptomatic patients to paresthesia, cramps, seizures, stridor, laryngospasm, cardiac arrhythmias, basal ganglia calcification, subcapsular cataracts, and dental enamel hypoplasia. This study aims to present the cases of two patients with rare causes of primary hypoparathyroidism and highlight the need for standardization...

hrp0098p2-313 | Late Breaking | ESPE2024

Correlation of Bone Health Index (BHI) and Metacarpal Index (MCI) with calcium metabolism parameters in children and adolescents

Ntova Maria , Chrysis Dionysios , Dermitzaki Eleni , N Michoula Aspasia , Christopoulos Panayiotis , Mastorakos George , N Grivea Ioanna , T Papadimitriou Dimitrios

Introduction: The assessment of bone maturation with artificial intelligence (AI) has introduced new straightforward indicators of bone health monitoring related the much more complex and expensive method of measuring bone density with DEXA (Dual-Energy X-Ray Absorptiometry). Bone Health Index (BHI) describes bone mass as a function of cortical thickness, width and length of the three middle metacarpals, using digital hand X-rays for bone age evaluation from D...

hrp0098p2-314 | Late Breaking | ESPE2024

Bone Health Index (BHI) and Metacarpal Index (MCI) in boys and girls on treatment with aromatase inhibitors

Piperidou Alexandra , Chrysis Dionysios , Dermitzaki Eleni , N Michoula Aspasia , Christopoulos Panayiotis , Mastorakos George , N Grivea Ioanna , T Papadimitriou Dimitrios

Third generation AIs have been repurposed as an off-label treatment in boys and girls, as they can retard closure of the epiphysial plate expanding the period of growth. Assessment of digital hand X-rays has introduced new follow-up indexes of bone health: Bone Health Index (BHI) from DICOM files describes bone mass as a function of cortical thickness, and Metacarpal Index (MCI) from digitized files expresses the cortical thickness standardized for the outer bone diameter at t...

hrp0098p3-284 | Late Breaking | ESPE2024

Dramatic deterioration of subclinical hyperparathyroidism in children and adolescents during the post-COVID-19 period

Loutsou Maria , Dermitzaki Eleni , Christopoulos Panayiotis , N Michoula Aspasia , Mastorakos George , Diamantopoulos Stavros , N Grivea Ioanna , T Papadimitriou Dimitrios

Vitamin D is a steroid hormone, essential for the immune system and bone health. Given that sun exposure is meant to provide at least 80% of daily vitamin D requirements, the COVID-19 pandemic is likely to have a considerable influence on calcium metabolism We retrieved anonymized data on calcium metabolism parameters assessing the occurrence of subclinical hyperparathyroidism – subclinical nutritional rickets (PTH ≥ 45 pg/ml with normal serum Ca ≤ 10.5 mg/dl) in c...

hrp0098p1-43 | Fat, Metabolism and Obesity 1 | ESPE2024

BIO-STREAMS: Multi-Pillar Framework for children Anti-Obesity Behavior building on an EU biobank, Micro Moments and Mobile Recommendation Systems

Kassari Penio , Genitsaridi Sofia-Maria , Ramouzi Eleni , Giannopoulou Eleni , Kokkou Eleni , Papadopoulou Marina , Koutaki Diamanto , Stefanou Garyfallia , Nikitas Christos , Bibas Athanasios , Prasinos Marios , Brisimi Theodora , Pitoglou Stavros , Georga Eleni , Mlakar Ιzidor , Kontogianni Meropi , Matsopoulos George , Koutsouris Dimitris , Charmandari Evangelia , behalf of BIO-STREAMS Consortium on

Introduction: The World Health Organization (WHO) European Regional Obesity Report 2022 stated that obesity rates have reached epidemic proportions across the European Union (EU). Obesity affects nearly one in three children (29% of boys and 27% of girls), and is associated with adverse psychological and psychosocial outcome and increased risk for noncommunicable diseases (NCDs). In addition, none of the 53 Member States are on track to meet the target of stop...

hrp0086p1-p251 | Diabetes P1 | ESPE2016

Metabolic Impairments among Adult Survivors of Paediatric Abdominal and Pelvic Tumours in the St Jude Lifetime Cohort Study

Wilson Carmen , Chemaitilly Wassim , Liu Wei , Srivastava Deokumar , Hudson Melissa , Robison Leslie , Ness Kirsten

Background: Adverse changes in metabolic parameters and body composition are frequently reported among childhood cancer survivors treated with cranial or total body irradiation. Data regarding the occurrence of metabolic impairments among survivors following abdominal and pelvic radiation are lacking.Objective and hypotheses: To define the prevalence of metabolic impairments among survivors of paediatric abdominal and pelvic solid tumours and to assess t...

hrp0084p1-82 | Growth Hormone | ESPE2015

Assessment of Primary Cancers in Growth Hormone–Treated Paediatric Patients Compared with General Population Registries: An Epidemiological Analysis of a Large, Multinational, Prospective Observational Study

Child Christopher , Zimmermann Alan , Jia Nan , Robison Leslie , Bramswig Jurgen , Blum Werner

Background: Concern remains regarding the potential influence of growth hormone (GH) treatment on neoplasia because of the general growth-inducing effect of GH and associations between high serum IGF1 concentrations and certain cancers in adulthood. Many studies that evaluated risk for primary cancer in GH-treated patients without previous malignancy found no increased rates of primary neoplasia. A higher risk for colorectal cancer was observed in a single-country cohort treat...

hrp0095p1-358 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Pathogenic and Low-Frequency genetic determinants in children with Central Precocious Puberty

Fanis Pavlos , Toumba Meropi , A Tanteles George , Iasonides Michalis , C Nicolaides Nicolas , Nicolaou Stella , Kyriakou Andreas , Neocleous Vassos , A Phylactou Leonidas , Skordis Nicos

Background: Central precocious puberty (CPP) due to premature activation of GnRH secretion results in early epiphyseal fusion and to a significant compromise in the achieved final adult height as well as psychological consequences. So far only a limited number of genetic determinants have been associated with the pathogenesis in children with CPP. In this original research, rare sequence variants in MKRN3, DLK1, KISS1, and KISS1R genes were i...

hrp0089p3-p405 | Multisystem Endocrine Disorders P3 | ESPE2018

Lessons from Wolfram Syndrome: Initiation of DDAVP Therapy Causes Renal Salt Wasting due to Elevated ANP Levels, Rescued by Fludrocortisone Treatment

Kleanthous Kleanthis , Maratou Eirini , Spyropoulou Dora , Dermitzaki Eleni , Bothou Christina , Papadimitriou Anastasios , Zoupanos George , Moutsatsou Paraskevi , Urano Fumihiko , Papadimitriou Dimitrios T.

Background-Hypothesis: Sudden initiation of treatment for diabetes insipidus (DI) with DDAVP causes abrupt volume expansion resulting in particularly high secretion of Atrial Natriuteric Peptide (ANP) (1). ANP blocks all stimulators of zona glomerulosa steroidogenesis, resulting in secondary mineralocorticoid deficiency and acute hyponatremia, causing renal salt wasting (RSW) (2). Cases: Two sisters, a 19-year-old girl (A) and a 7-year-old girl (B) with Wolfra...

hrp0089p3-p410 | Multisystem Endocrine Disorders P3 | ESPE2018

A Novel Detrimental Homozygous Mutation of WFS1 Gene in Two Sisters from Non-consanguineous Parents with Untreated Diabetes Insipidus

Papadimitriou Dimitrios T , Kleanthous Kleanthis , Manolakos Emmanouil , Tiulpakov Anatoly , Nikolopoulos Thomas , Delides Alexandros , Voros Gerasimos , Dinopoulos Argyrios , Zoupanos George , Urano Fumihiko

Background: Wolfram syndrome (WS) is a rare autosomal recessive genetic disorder. We present two sisters from non-consanguineous parents, who presented to our pediatric endocrinology clinic due to severe polyuria-polydipsia with inappropriately treated DM (HbA1c 8.2% and 10.1%) and untreated DI.Methods: DNA was tested with PCR amplification and sequencing analysis (Sanger sequencing) of the entire coding region and all exon-intron splice junctions of the...