ESPE Abstracts

Introduction: Children with idiopathic short stature have linear growth impairment despite normal or even high levels of GH. In some of these children IGFI level is low (NGH + Low IGFI (IGFSDS<-1.5). It was observed that some children with GHD (Peak GH < 7 ng/dl after provocation) have normal IGFI levels (GHD +Normal IGFI). The linear growth of these two groups at presentation and their response to GH therapy was not studied well.<p class="abstext"...

Background: Short stature is clearly not a disease, but is commonly perceived to be associated with social and psychological disadvantage.Objective and hypotheses: To evaluate the psychological changes in children with short stature after growth hormone therapy.Method: One hundred and thirty children aged 6–14 years old were diagnosed as short stature (ISS and GHD). And they were divided into intervention group (55 children) a...

Objective: In boys during puberty who were undergoing recombinant human growth hormone (rhGH) treatment, we compared the therapeutic efficacy and any adverse reactions, of co-therapy with letrozole/gonadotropin releasing hormone analog (GnRHa).Methods: Fifty-six pubertal growth hormone deficiency (GHD) boys were studied, they were treated with the combination of letrozole and rhGH (letrozole group) or GnRHa and rhGH (GnR...

Objective: The first line of treatment for Cushing&grave;s disease (CD) is transsphenoidal surgery (TSS), whose effectiveness range is from 70 to 90%. If surgical treatment is unsuccessful or recurrence appears, radiation treatment (RT) is the next therapeutic option, which effectiveness range is also 90%, but the hypopituitarism rate as side effect of treatment is higher.Aim: Analysis of recurrence rates of CD and side ...

Background: Although Ramadan fasting is one of the five pillars of Islam and is compulsory for all healthy Muslims from puberty onwards, religious exemptions exist for patients with type 1Diabetes. The risks of fasting include: hyperglycemia, hypoglycemia, ketoacidosis, thrombotic episodes, and dehydration. Many adolescents still insist to fast due to religious or social motives.Objectives: To study the risks and metabol...

Aim: to assess and follow-up anthropometric and biochemical parameters in patients with abdominal obesity after a lifestyle intervention.Patients, Material and Methods: 122 children and adolescents with abdominal obesity, aged 7 to 16 years, were included in a control randomized intervention study (NCT031472). Abdominal obesity was diagnosed using the waist circumference. The intervention included an intensive phase duri...

Silver-Russell syndrome (SRS) is a rare heterogeneous syndrome associated with severe prenatal and postnatal growth retardation.Context: There is little information on puberty onset and bone age trend in children with SRS.Study Design and partecipants: Retrospective observational study, including patients with a confirmed diagnosis of SRS divided in 2 molecular groups [ 11p15 loss of methylation, (...

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive diseases caused by a deficiency of enzymes responsible for the steroidogenesis. The most common cause is 21-hydroxylase deficiency. There are three forms of CAH due to 21-hydroxylase deficiency: the classic form with salt loss, the classic virilizing and the non-classical form. In pediatric age, CAH is most often manifested by masculinization of the genitals of female newborns, adrenal crisis or premature p...

Background: Congenital hypothyroidism (CH) can be categorized into two types: transient CH (group T) and permanent CH (group P). Several studies have recently demonstrated that the levothyroxine (LT4) dosage is useful for predicting LT4 requirement; however, none of the studies followed up their patients to puberty.Objective: To determine the cutoff value for the LT4 dosage as a predictor of LT4 requirement after puberty...

Abstract: Diabetic ketoacidosis(DKA) is a potentially fatal complication in patients with type 1 diabetes mellitus(T1DM). The mainstay of treatment for DKA is correction of dehydration and correcting hyperglycaemia with insulin. Intravenous(IV) insulin is preferred over subcutaneous(SC) insulin as onset of action is rapid and the dose can be titrated based on blood glucose.Aims: To compare efficacy and hospitalisation co...