hrp0094p2-365 | Pituitary, neuroendocrinology and puberty | ESPE2021

Gonadotropin Flare with Different Depot GnRH Agonists: Comparative Analysis.

Freire Analia , Arcari Andrea , Gabriela Ballerini Maria , Ignacio Bergada , Gabriela Ropelato Maria , Gryngarten Mirta ,

Central precocious puberty (CPP) is effectively treated by inhibition of GnRH signaling through GnRH receptor desensitization with depot GnRH agonists (dGnRHa), but the first injection is associated with a surge in LH and FSH (flare) that proportionally increases estradiol levels. When estradiol levels drop, usually within a fortnight, vaginal bleeding may be seen in a small number of girls. Although dGnRHa that use higher, longer-acting doses are increasingly being used in gi...

hrp0097p2-8 | Growth and Syndromes | ESPE2023

Growing Tall and Staying Slim During a Pandemic: The Power of rGH

Pop Raluca-Monica , Aurelian Tiuca Robert , Maria Radulescu Flavia , Ionela Pascanu Maria

Keywords: COVID 19, height trajectory, rGHBackground: Various factors can interfere with height and body mass index (BMI) trajectories and therefore, auxological parameters reflect children’s health status. The COVID-19 pandemic has had an important impact on all the social determinants of health.Aim: The aim of the current study was to assess the effect of recombinant growth...

hrp0098rfc3.5 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2024

Long-Term Health Outcomes of Delayed Puberty in Males: A Comprehensive Population-Based Study

Lodefalk Maria , Lennartsson Otto , Rodanaki Maria , Cao Yang , Lodefalk Magnus , Nilsson Ola

Introduction: Delayed puberty in boys, defined as lack of pubertal onset by the age of 14 years, is often constitutional and self-limited. However, it can lead to feelings of sadness and anxiety. The long-term health consequences of delayed puberty in males are not well understood.Objective: To study the long-term morbidity in young men exposed to delayed puberty.Methods: All Swedi...

hrp0098p1-196 | Sex Endocrinology and Gonads 2 | ESPE2024

Survey of pediatricians on the care provided to children with gender diversity

Alija Maria , del Rio Inés , J. Chueca Maria , Riaño Isolina

In recent years we have witnessed an increase in the demand for health care by minors with gender diversity. Comprehensive biopsychosocial care for these individuals is a complex process, which must be facilitated for all of them.Objective: The survey strategy aimed at primary care pediatricians aims to provide the starting point for proposals for improvement, in response to the needs expressed by professionals. It is also intended to co...

hrp0098p2-295 | Thyroid | ESPE2024

Graves' Disease in Children and Adolescents: A 10 years’ retrospective analysis of patients followed in a Single Center

Gkougkouli Eleni , Dolianiti Maria , Vasilakis Ioannis-Anargyros , Sakka Sofia , Nikolaides Nicolas , Mpinou Maria , Kanaka Gantenbein Christina

Introduction: /Purpose: Graves' disease is the most common cause of hyperthyroidism in children and adolescents. It is an autoimmune disorder characterized by stimulating autoantibodies, leading to increased thyroid hormone release and thyrotoxicosis. Early initiation and long-term treatment, remission, and definitive treatment with thyroidectomy or radioactive iodine present a challenge. This study aims to record the data of patients with Graves' disease foll...

hrp0095p1-532 | Growth and Syndromes | ESPE2022

Cerebral aneurysms and kidney disease in a child with microcephalic osteodysplastic primordial dwarfism type II: novel homozygous mutation in the PCNT gene.

Petraroli Maddalena , Percesepe Antonio , Piane Maria , Gnocchi Margherita , Messina Giulia , Lattanzi Claudia , D'alvano Tiziana , Dora Patianna Viviana , Ormitti Francesca , Maria Roberta Esposito Susanna , Elisabeth Street Maria

MOPD is known to be caused by homozygous loss-of-function mutations in a specific gene, PCNT. Both intra- and interfamilial clinical variability (even for the same variant) have been frequently observed, which makes it difficult to infer a genotype–phenotype correlation. Pericentrin (PCTN) is a structural protein expressed in the centrosome that plays a fundamental role in anchoring protein complexes, regulating mitotic cycle and thus cell proliferation. High levels of m...

hrp0089rfc6.6 | Fat, Metabolism and Obesity | ESPE2018

Effects of Cherry’s Extract on Increased Osteclastogenesis in Obese Children

Faienza Maria Felicia , Corbo Filomena , Carocci Alessia , Catalano Alessia , Piacente Laura , Clodoveo Maria Lisa , Bortolotti Sara , Storlino Giuseppina , Colucci Silvia , Grano Maria , D'Amato Gabriele , Brunetti Giacomina

The accumulation of adipose tissue, especially visceral fat, represents a risk factor for reduced bone mineral density and spontaneous fractures. Several mechanisms have been proposed to explain the complex relationship between adipose tissue and bone. Obesity is associated with the production of inflammatory cytokines both by adipocytes and immune cells which may stimulate bone resorption and reduce bone strength. Studies in vitro and in vivo have reported t...

hrp0086fc4.4 | Pathophysiology of Obesity | ESPE2016

The Role of Apoptotic Marker Apo-1/Fas in the Metabolism and Endothelial Function of Healthy Children

Maganna Maria , Katsa Maria Efthymia , Ioannidis Anastasios , Zyga Sofia , Tsironi Maria , Sachlas Athanasios , Routsi Kleopatra , Dolianiti Loukia , Rojas Gil Andrea Paola

Background: Apoptosis is a programmed sequence of events towards cell death. Blood vessels employ apoptosis for remodeling during development and to maintain homeostasis during adulthood. The atherosclerotic process begins in early childhood and is correlated with obesity and metabolic disorders.Objective and hypotheses: To investigate the correlation of apoptotic marker Apo-1/Fas with children’s biochemical and anthropometric characteristics.<p...

hrp0082fc3.1 | Diabetes | ESPE2014

High Mobility Group Box-1 Serum Concentrations Increase at Onset of Diabetes in Cystic Fibrosis Patients

Montanini Luisa , Smerieri Arianna , Pisi Giovanna , Giardino Ida , Ziveri Maria Angela , d'Apolito Maria , Cesari Silvia , Spaggiari Cinzia , Merli Silvia , Bernasconi Sergio , Street Maria E

Background: The DNA-binding High Mobility Group Box-1 (HMGB1) is an intracellular gene regulator that can be secreted also in response to inflammatory mediators, including interleukins, binding subsequently to both RAGE and Toll-like receptors forming a self-reinforcing inflammatory circle. Cystic fibrosis (CF) is a condition characterized by chronic inflammation. Elevated serum HMGB1 concentrations were described in serum of obese children and to be associated with the metabo...

hrp0082p2-d3-360 | Diabetes (2) | ESPE2014

‘My Diabetes’ Application for Android Devices as a Diabetes Management Tool

Ballester Maria Jose , Santillana Luis Alberto , Varvanov Rossen , Buch-Gasz Katarzyna , Gasz Adam , Sanchez Maria Jose , Lopez Carmen Maria , Martin Elena , Palomo Enrique

Introduction: A fundamental element in the successful diabetes management is the education of patients. Modern technology opens new horizons and provides new tools in empowering patients in their learning process.Objectives: Presentation, evaluation and critical medical review of ‘My Diabetes’ application whose Spanish version has been studied, reviewed and analysed in detail by our endocrinology unit and D-parents. Provide insight into its pot...