hrp0092p1-136 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Serum Estradiol is Associated with Inhibin B in Healthy 1-6 Years Old Girls

Birkebaek Niels H. , Schørring Mia E. , Frederiksen Hanne , Kamperis Konstantinos , Kristensen Kurt , Rittig Søren , Juul Anders , Vestergaard Esben T

Background: The female gonadal axis is activated in mini-puberty and thereafter it is quiescent until puberty. We have shown that many girls with no clinical sign of puberty in the age group 1-6 yr. have a rather strong luteinizing hormone (LH) and follicle stimulating hormone (FSH) response to a gonadotropin releasing hormone (GnRH) test. However, stimulated LH and FSH values decreased in the age interval 1-6 yr and no LH/FSH values rose above 0.43. Serum est...

hrp0084p3-1003 | Gonads | ESPE2015

Antimullerian Hormone and Inhibin B Markers of the Ovarian Reserve After Ovariectomy

Morandi Grazia , Piona Claudia Anita , Ben Sarah Dal , Ramaroli Diego , Cavarzere Paolo , Antoniazzi Franco , Gaudino Rossella

Background: Ovarian reserve is defined as the functional potential of the ovary, which reflects the number and quality of the follicles left in the ovary at any given time. In literature there studies about the evaluation of ovarian reserve after ovariectomy for tumors and cysts, using serum markers, such as inhibin-B, and anti-Mullerian hormone (AMH), combined to ultrasonographic markers, in adult women but none in peri-pubertal girls.Case presentation:...

hrp0092p3-83 | Diabetes and Insulin | ESPE2019

Diabetes Mellitus in a 16-Year-Old Boy Developing Multiple Neuro-Endocrine Dysfunctions in the Course: Is it Type 1 Diabetes or Wolfram Syndrome, or Both?

Santi Maristella , Emma Flück Christa , Böttcher Claudia

Introduction: Autosomal recessive mutations in the Wolfram syndrome type 1 gene are responsible for the classical Wolfram syndrome (OMIM_ 222300), also known by the acronym "DIDMOAD" (diabetes insipidus, diabetes mellitus (DM), optic atrophy and deafness). The gene encodes wolframin, a membrane glycoprotein, which helps to regulate the calcium homeostasis in the endoplasmic reticulum of many different tissues, including the pancreatic...

hrp0089p2-p328 | Pituitary, Neuroendocrinology and Puberty P2 | ESPE2018

AMH and Inhibin B Level in Girls with Central Precocious Puberty

Jeong Hwal Rim , Hwang Il Tae , Yi Kyung Hee

Background/aim: Anti – Müllerian hormone (AMH) and Inhibin B (INHB) are considered as possible biomarker of central precocious puberty(CPP). This study investigated serum AMH and INHB level in central precocious puberty andanalyzed clinical factors associated with these two hormone levels.Methods: In total, 48 girls with CPP and 35 age – matched prepubertal girls were enrolled in the study. The subjects were divided into two groups as CPP ...

hrp0082p1-d2-215 | Reproduction (1) | ESPE2014

Serum Inhibin-B Values in Boys with Unilateral Cryptorchidism and Boys with Unilateral Vanished Testis

Cortes Dina , Thorup Jorgen

Background: In some recent materials of blood samples from boys with cryptorchidism gonadotropins are higher and serum inhibin-B lower than normal. Inhibin-B is produced by the Sertoli-cells and to some extent serum values of inhibin-B reflect the state of germinative epithelium in cryptorchid testes. In boys with bilateral vanished testes the serum inhibin-B level is close to zero.Objectives and hypotheses: Aim of study was to evaluate the serum inhibin...

hrp0086p1-p727 | Pituitary and Neuroendocrinology P1 | ESPE2016

Changes of Serum AMH and Inhibin B Levels in Girls with Central Precocious Puberty before and During Treatment with GnRH Agonists

Oh Yeon Joung , Baek Joon Woo , Kang Min Jae , Yang Seung , Hwang Il Tae

Background: In girls with central precious puberty (CPP), the hypothalamic-pituitary-gonadal axis is prematurely activated. If the girl is treated with GnRH agonist (GnRH-a), gonadotropins levels become suppressed.Objective and hypotheses: We aimed to evaluate whether serum antimu llerian hormone (AMH) and inhibin B levels are affected in girls with CPP and whether pituitary suppression by GnRH-a affects serum AMH and inhibin B levels.<p class="abste...

hrp0095p1-292 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2022

Management and outcomes of congenital hyperinsulinism in infants and young children: a 5-year-experience from the tertiary referral hospital in Indonesia

Fadiana Ghaisani , Soesanti Frida , B Pulungan Aman , Tridjaja Bambang , RL Batubara Jose

Background: Congenital hyperinsulinism (CHI) is a rare condition that becomes the most frequent cause of severe and persistent hypoglycemia in infants and young children. It may lead to debilitating morbidity and mortality if being diagnosed lately. Congenital hyperinsulinism can be caused by monogenic or syndromic disorders. The prevalence of CHI in Indonesia is still unknown. However, the increasing number of cases referred to the tertiary hospital recently ...

hrp0082p3-d3-940 | Puberty and Neuroendocrinology (1) | ESPE2014

Inhibin B in the Boys with Constitutional Delay of Puberty: Relationship with Gonadotropins, Testosterone, and Anti-Müllerian Factor

Latyshev Oleg , Kiseleva Elena , Okminyan Goar , Samsonova Lubov

Objective: The aim of this study were to investigate the level of inhibin B and its relationship with testosterone, anti-Müllerian factor, basal, and GnRH-stimulated gonadotropin hormones (LH and FSH) concentration in boys with constitutional delay of puberty.Material and methods: In the study were included 15 boys (mean age 14.5±1.6 years) in Tanner stages 1–2. The investigation consists of genital examination with prader orchidometer, de...

hrp0084p1-111 | Puberty | ESPE2015

Serum Neurokinin B Level can be Used to Differentiate Central Precocious Puberty from Premature Thelarche

Parlak Mesut , Turkkahraman Doga , Ellidag Hamit Yasar , Parlak Ayse Eda

Background: Neurokinin B and kisspeptin appear to play main roles in puberty.Aims and objectives: The aim of the present study was to investigate the diagnostic role of kisspeptin and neurokinin B in central precocious puberty (CPP) and premature thelarche (PT).Methods: The girls who presented with breast development (between 5 and 8 years) were included in the study. All cases underwent bone age (BA) assesment. Basal serum FSH, LH...

hrp0086p1-p733 | Pituitary and Neuroendocrinology P1 | ESPE2016

The Influences of Circulating Leptin, Kisspeptin, and Neurokinin B Levels to Precocious Puberty in Obese Girls

Kang Min Jae , Kim Eun Young , Oh Yeon Joung , Baek Joon Woo , Yang Seung , Hwang Il Tae

Background: Leptin has a major role in the metabolic gating of pubertal maturation. Kisspeptin is an essential gatekeeper of puberty. Neurokinin B (NK B) is not widely known in the precocious puberty (PP) but it is coexpressed with kisspeptin in the arcuate nucleus and synchronizes the pulsatile secretion of kisspeptin.Objective and hypotheses: Leptin, kisspeptin, and NK B are influenced by energy balance and metabolic status has a clear impact on the ti...