hrp0098p1-281 | Sex Endocrinology and Gonads 3 | ESPE2024

Comparison between, clinical, metabolic and hormonal parameters and selected microRNAs in adolescent girls with PCOS and healthy controls

Mladenov Vilhelm , Galcheva Sonya , Radanova Maria , Iotova Violeta

Background: Polycystic ovary syndrome (PCOS) is the most common hyperandrogenic disorder in pubertal girls affecting between 3 and 11 % of them. Menstrual irregularities and hyperandrogenism are the main characteristics of the syndrome. PCOS is associated with obesity, cardiovascular complications, impaired fertility and increased cancer risk in adulthood. Some of these complications are potentially preventable with timely diagnosis, life-style change and phar...

hrp0098p2-228 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Can Hypophysitis Mask Pituitary Stalk Germinoma? Insights from a Case Series Analysis.

Pipino Camila , Zepeda Diego , Okuma Cecilia , Guarda Francisco , Hernandez Maria

Introduction: Pituitary stalk thickening (PST) is a rare disease and can cause hormonal deficits and/or mass effect. The most frequent causes in pediatric age are germ cell tumors (GCT) and Langerhans cell histiocytosis (LCH). Hypophysitis with extension to the stalk is extremely rare in pediatric patients. The aimis to describe 4 pediatric patients which were first diagnosed as hypophysitis but final diagnosis was GCT.Clinical C...

hrp0095rfc1.3 | Thyroid | ESPE2022

The importance of extra-endocrine features at infancy in multiple endocrine neoplasia type 2B for early diagnosis

Giulia Mirra , Annalisa Deodati , Maria Elisa Amodeo , D'Aniello Francesco , Armando Grossi , Emanuele Agolini , Marco Cappa , Grazia Maria Ubertini

Background: Multiple endocrine neoplasia type 2B is a rare genetic syndrome caused by germline mutations in the RET proto-oncogene. Approximately 75% of MEN2B cases are sporadic and caused by de novo RET mutations, whereas 25% of cases occurs in families with an autosomal dominant inheritance. The most common RET mutation found in 95% of MEN2B patients is the substitution of the amino-acid threonine for methionine at codon 918. In infants with de novo mutation...

hrp0095p1-436 | Diabetes and Insulin | ESPE2022

Association of the apoptotic markers Apo1/Fas and cCK-18 and the adhesion molecule ICAM-1 with Type 1 diabetes mellitus in children and adolescents.

Kostopoulou Eirini , Efthymia Katsa Maria , Ioannidis Anastasios , Foti Maria , Dimopoulos Ioannis , Spiliotis Bessie , Paola Rojas Gil Andrea

Introduction: Type 1 diabetes mellitus (T1DM) is characterized by insulin-producing pancreatic β-cells loss. Apo1/Fas, a glycosylated surface protein, is implicated in maintaining homeostasis of the immune system. Cytokeratin-18 (cCK-18) is a predictive marker of liver disorders in T2DM. Intercellular adhesion molecule-1 (ICAM-1) is considered a candidate gene for susceptibility to diabetes mellitus. Aim: To investigate the possible role of Apo1/Fas, cCK-...

hrp0095p1-194 | Thyroid | ESPE2022

Response to initial treatment in a pediatric cohort of patients with papillary thyroid cancer (PTC): changes after 3 years of follow up

Papendieck Patricia , Eugenia Masnata Maria , Gabriela Ballerini Maria , Medin Martin , Elias Eugenia , Mateos Fernanda , Bergada Ignacio , Elena Chiesa Ana

Background: Childhood onset PTC has a more aggressive presentation but no overall increase in mortality compared to adults.Objective: To characterize a pediatric cohort with PTC at diagnosis using the American Thyroid Association (ATA) Initial Risk Stratification (IRS) and to evaluate the response to initial treatment until 3 years based on the modified ATA Dynamic Risk Stratification (DRS) for adults.<p class="abste...

hrp0095p1-387 | Thyroid | ESPE2022

Pediatric Graves Disease (PGD): presentation, treatment and follow up. A single center Argentine perspective

Rothenfusser Anna , Eugenia Masnata Maria , Suco Valle Sofia , Eugenia Rodriguez Maria , Bergada Ignacio , Papendieck Patricia , Elena Chiesa Ana

Introduction: PGD is characterized by hyperthyroidism and antibodies against the TSH receptor (TSHRAB). Reported annual incidence is 4,58/100,000.Objective: To describe an Argentinean cohort with PGD followed between 2006 and 2020 at the Ricardo Gutierrez Children’s Hospital.Material and Methods: Retrospective study of 69 patients, who were treated initially with antithyroid ...

hrp0095lb13 | Late Breaking | ESPE2022

Residual C-peptide secretion and glycemic control in pediatric patients with Diabetes Mellitus type 1

João Gaia Maria , Pedrosa Inês , Adriana Rangel Maria , Arménia Campos Rosa , Luísa Leite Ana

Introduction: Residual C-peptide secretion has been associated with less hypoglycemic events and lower glycemic variability in patients with Diabetes Mellitus type 1 (DM1), primarily in adults. The authors sought to evaluate the association between residual C-peptide secretion in pediatric patients with DM1 and glycemic control variables.Methods: Cross-sectional study conducted in a level II hospital, in DM1 patients you...

hrp0095p2-105 | Fat, Metabolism and Obesity | ESPE2022

A Comprehensive Multidisciplinary Management Plan Is Effective in Reducing the Prevalence of Overweight and Obesity in Adolescence

Binou Maria , Tragomalou Athanasia , Ramouzi Eleni , Koutaki Diamanto , Vourdoumpa Katerina , Manou Maria , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia

Background: Obesity in adolescence represents a major health problem of our century owing to its epidemic proportions and the associated morbidity and mortality in adult life. In Greece, 41% of adolescents are overweight or obese.Aim: The aim of our study was to investigate the effectiveness of a comprehensive, multidisciplinary, personalized management plan at reducing the prevalence of overweight and obesity in adolesc...

hrp0092p1-334 | Fat, Metabolism and Obesity (2) | ESPE2019

ADCY3 Genetic Variants in Cypriot Obese Children

Frixou Maria , Fanis Pavlos , Skordis Nicos , Stylianou Charilaos , Tanteles George A , Toumba Meropi , Neocleous Vassos , Phylactou Leonidas A , Pantelidou Maria

Background: The adenylate cyclase 3 (ADCY3) gene encodes a membrane-associated protein involved in the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This gene seems to be is involved in the regulation of several metabolic processes and has been recently associated to pathophysiological metabolic conditions. Several ADCY3 variants have been linked with obesity in children.M...

hrp0092p2-277 | Thyroid | ESPE2019

Congenital Hypothyroidism: Neonatal SCREENING PROGRAM with T4 and TSH

Chueca Maria J. , Moreno Paula , Dura Teodoro , Berrade Sara , Andres Carlos , Garcia Maria Dolores , Moreno Jose Carlos , Ascunce Nieves

Objectives: -To determine children diagnosed with central congenital hypothyroidism (CCH) by a screening program using TSH and total T4 between May 2016 and January 2019.-To analyze the characteristics of the disease in these children.Material and Methods: During the time of the study, 14.743 newborns have been screened. Cut-off points are used for TSH ≥10MU/ml and T4 6 and 20 mg/dl as lower ...