hrp0086p1-p630 | Growth P1 | ESPE2016

GH-Pattern with High Trophs are Often Found after Daily sc rhGH-Injection in Children

Lundberg Elena , Andersson Bjorn , Kristrom Berit , Rosberg Sten , Albertsson-Wikland Kerstin

Background: Endogenous GH pattern is characterized by high peaks (growth signal) and low trophs (metabolic signal). Exogenous GH is given by subcutaneous injection (scGH-injection) daily at bedtime.Objective and hypotheses: To study the factors influencing intra-/interindividual variation of pharmacokinetics and pattern of scGH-injection in GH treated children.Method: One hundred and twenty eight subjects followed yearly ≤ 8 ...

hrp0086p2-p665 | Growth P2 | ESPE2016

Association between IGF-1 (Insulin-Like Growth Factor) SD Levels and Children with Growth Hormone Deficiency with and without Pituitary Morphological Abnormalities

Claudia Schmitt-Lobe Maria , Frare Dionara , Greco Rafael

Background: The diagnostic use of IGF-1 in children suspected of GHD is based on the assumption that a single determination of this parameter reflects the integrated 24-h GH secretion. IGF-1 levels are low in GHD, but a study found a significantly lower sensitivity in children with organic lesions in the brain.Objective: The aim of this study was to check if there is a statistically significant relation between IGF-1 values in children with GHD with and ...

hrp0086p2-p666 | Growth P2 | ESPE2016

Usefulness of Growth Hormone Transient Treatment Suspension in Prepubertal Children Treated with Growth Hormone

Martinez Barahona Maria , Cecenarro Laura , Murillo Valles Marta , Luisa Granada Ybern M. , Ropero Ramos Esther , Bel Comos Joan

Background: The primary goal of treatment is to achieve a final height within the normal range and avoid the physical and psychological consequences of short stature (SS). If after a time, treatment efficacy criteria are not achieved, it is necessary to revalue its usefulness. There is no consensus about which conduct should be adopted in these cases. An alternative, is the suspension of rhGH treatment and evaluate the clinical and biochemical results to decide to continue or ...

hrp0086p2-p761 | Pituitary and Neuroendocrinology P2 | ESPE2016

Paediatric Cushing Disease: One Patient’s Path to Cure

Yordanova Galina , Iotova Violeta , Zheleva Eleonora , Bachvarov Chavdar , Bocheva Yana , Galcheva Sonya , Enchev Yavor , Ivanov Krasimir , Kolev Nikola , Tonev Anton , Storr Helen

Background: Paediatric Cushing disease (CD) is rare but can be severe. Diagnosis and proper management are often delayed and the course of disease is unpredictable. Support from experts in the field is essential.Objective and hypotheses: We present a male patient, diagnosed with Cushing syndrome elsewhere more than two years after his initial signs and symptoms. For 6 months he underwent numerous investigations, which were inconclusive and was left untre...

hrp0082wg2.7 | Global paediatric Endocrinology and Diabetes | ESPE2014

Long Acting Insulin: Friend or Foe?

de Beaufort Carine

Current treatment in type 1 diabetes focuses on the development of physiological insulin replacement. Although this has led to the increased progress in the development of semi closed loop systems and different algorithms allowing this, the majority of youth still has to cope with insulin injections. Improving metabolic outcome with injection therapy has become more demanding, imposing an increased number of injections and improved knowledge of food composition. For those able...

hrp0082fc4.2 | Growth | ESPE2014

The Effect of grB10-Deficiency in Zebrafish: A Translational Animal Model to Study Human Growth

De Leonibus Chiara , Barinaga-Rementeria Ramirez Irene , Hurlstone Adam , Clayton Peter , Stevens Adam

Background: GRB10 negatively regulates IGF1 signalling, influences growth and promoter polymorphisms are associated with GH response1. GRB10 knockout-mouse models display foetal overgrowth2, however, the mouse model has only partial similarity to human growth3. There is evidence that the zebrafish is an appropriate model to study growth4 and has the advantage of being easily genetically manipulated.<p class="abs...

hrp0082p1-d2-3 | Adrenals &amp; HP Axis | ESPE2014

Transient Generalized Glucocorticoid Hypersensitivity: Clinical Manifestations, Endocrinologic Evaluation, and Transcriptomic Profile: the Potential Role of nf-κb

Nicolaides Nicolas C , Lamprokostopoulou Agaristi , Polyzos Alexandros , Kino Tomoshige , Katsantoni Eleni , Triantafyllou Panagiota , Christophoridis Athanasios , Katzos George , Drakopoulou Maria , Sertedaki Amalia , Chrousos George P , Charmandari Evangelia

Background: Transient generalized glucocorticoid hypersensitivity is a rare disorder characterized by increased tissue sensitivity to glucocorticoids and compensatory hypoactivation of the hypothalamic–pituitary–adrenal (HPA) axis. The condition itself and the molecular mechanisms that underlie its pathophysiology have not been elucidated as yet. Adenovirus 36 has been reported to cause obesity in various animal species.Objective and Hypotheses...

hrp0082p1-d3-17 | Adrenals &amp; HP Axis (1) | ESPE2014

Aldosterone/Renin Ratio as Key Player in the Diagnosis of Primary Hypoaldosteronism in Newborns and Infants

Ruecker Beate , Lang-Muritano Mariarosaria , Spanaus Katharina , Welzel Maik , Lallemand Dagmar , Phan-Hug Franziska , Konrad Daniel , Katschnig Claudia , Holterhus Paul-Martin , Schoenle Eugen

Background: Primary hypoaldosteronism (PA) is a rare inborn disorder with life-threatening symptoms in newborns and infants due to an aldosterone synthase defect. As plasma aldosterone concentration (PAC) can remain in the normal range, interpretation of the laboratory findings could be difficult and might lead to delayed initiation of therapy.Objective and Hypotheses: This study aims to show that PAC/PRC (plasma renin concentration) rat...

hrp0082p1-d1-103 | Fat Metabolism &amp; Obesity | ESPE2014

TNF-Related Apoptosis-Inducing Ligand Induces a Pro-Inflammatory Secretion Profile in Human Adipocytes

Zoller Verena , El Hay Muad Abd , Funcke Jan-Bernd , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: Obesity is tightly associated with adipose tissue inflammation. Tumor necrosis factor-alpha (TNFα) has been identified as a key player in this inflammatory process and has been linked to the development of obesity-associated insulin resistance. Our group studies the involvement of TNF superfamily members in obesity-induced alterations in adipose tissue.Objective and hypotheses: Here, we aimed to identify the effects of the TNF superfamil...

hrp0082p1-d1-110 | Fat Metabolism &amp; Obesity | ESPE2014

Free Fatty Acids Activate Hypothalamic Astrocytes in a Sexually Dimorphic Manner

Argente-Arizon Pilar , Fuente-Martin Esther , Diaz Francisca , Freire-Regatillo Alejandra , Argente Jesus , Chowen Julie A

Introduction: Obesity is known to associate with chronic systemic inflammation. However, hypothalamic inflammation also occurs in response to high fat diet (HFD)-induced obesity and is proposed to participate in central insulin/leptin resistance and the perpetuation of weight gain and systemic affectation. The weight gain and central responses to HFD differ between males and females. As hypothalamic glial cells are implicated in the central inflammatory response we hypothesize...