hrp0086p2-p681 | Growth P2 | ESPE2016

Evaluation of GH Deficient Pre Pubertal Children Treated with Omnitrope® Using the AuxoLog Computer Program

del Campo Maria Ruiz , Gonzalez Jose Revorio , Lechuga Alfonso , Gila Ana Lucia Gomez , Cancio Monica Fernandez , Carrascosa Antonio , Garcia Margarida Palla

Background: AuxoLog is a validated computer program that evaluates auxologic parameters comparing them with the Spanish growth charts. It also allocates subjects to the corresponding pubertal development group.Objective: To assess the evolution of auxological parameters in GH deficient (GHD) pre pubertal children treated with Omnitrope for a minimum of 2 years prior to puberty.Method: This study is non-interventional, retrospective...

hrp0084p3-821 | Endocrine Oncology | ESPE2015

Primary Hypogonadism after Haematopoietic Stem Cell Transplant in Paediatric Patients with Cancer

Alemany Maria Del Carmen De Mingo , Orti Raquel Segovia , Macian Francisca Moreno , Carinena Sara Leon , Moreno Maria Del Mar Andres , Navarro Jose Maria Fernandez

Background: Gonadal function is altered up to 25% in patients who suffered cancer in childhood. Cryopreservation of ovarian tissue (COT) is an option for preserving fertility.Aims and objective: To establish the prevalence of primary hypogonadism (PH) in children with cancer after hematopoietic cell transplantation (HCT). To analyse the variables that predict progression to PH.Methods: Retrospective cohort study. Patients aged 0 to...

hrp0084fc10.2 | Perinatal Endocrinology | ESPE2015

The Altered Circulating miRNA Profile in Maternal Obesity Associate with Pre- and Post-Natal Growth

Bassols Judit , Carreras-Badosa Gemma , Bonmati Alexandra , Ortega Francisco-Jose , Mercader Josep-Maria , Prats-Puig Anna , Sanchez Josefa , deZegher Francis , Ibanez Lourdes , Fernandez-Real Jose-Manuel , Lopez-Bermejo Abel

Background: Gestational obesity has not only adverse effects on the mothers’ health but also on the developing fetus. Newborns of obese pregnant women have increased birth weight and increased risk for obesity and associated diseases in adulthood. The mechanisms by which maternal nutrition induce these changes in the offspring may involve microRNAs (miRNAs) regulation.Aims and objectives: To study the associations between circulating miRNAs altered ...

hrp0084fc10.3 | Perinatal Endocrinology | ESPE2015

Circulating miRNA Expression Profile in Pregestational and Gestational Obesity

Bassols Judit , Carreras-Badosa Gemma , Bonmati Alexandra , Ortega Francisco-Jose , Mercader Josep-Maria , Prats-Puig Anna , Sacot Neus , deZegher Francis , Ibanez Lourdes , Fernandez-Real Jose-Manuel , Lopez-Bermejo Abel

Background: miRNAs are valuable circulating biomarkers and therapeutic targets for metabolic diseases. A differential pattern of miRNAs has been described in pregnant women with preeclampsia or gestational diabetes; however, it is unknown whether maternal obesity affects the profile of circulating miRNAs.Aims and objectives: To define the circulating pattern of miRNAs in pregestational and gestational obesity; and to explore their associations with mater...

hrp0084p1-64 | DSD | ESPE2015

MAMLD1 Mutations Seem Not Sufficient to Explain a 46, XY DSD Phenotype. What else?

Camats Nuria , Fernandez-Cancio Monica , Audi Laura , Mullis Primus E , Moreno Francisca , Casado Isabel Gonzalez , Lopez-Siguero Juan Pedro , Corripio Raquel , de la Vega Jose Antonio Bermudez , Blanco Jose Antonio , Fluck Christa E

Background: The MAMLD1 gene (Xp28) is thought to cause disorder of sex development (DSD) in 46, XY patients, mostly presenting with hypospadias, and, recently, also gonadal dysgenesis. However, there is some controversy about the role of MAMLD1 in sex development because i) some MAMLD1 variants are also detected in normal individuals, ii) others are not present in all affected DSD individuals of the same family; iii) several MAMLD1 mutations...

hrp0082p3-d2-781 | Fat Metabolism & Obesity (1) | ESPE2014

Relationship Between Adiposity Degree and Physical Activity and Inactivity Among Children and Adolescents

Leis Rosaura , Vazquez-Cobela Rocio , Bedoya Juan Jose , Seoane Luisa Maria , Barja-Fernandez Silvia , Aguilera Concepcion , Olza Josune , Bueno Gloria , Gil-Campos Mercedes , Castro-Feijoo Lidia , Moreno Luis , Gil Angel , Tojo Rafael

Introduction: The highest prevalence of children and adolescents with obesity in Europe is observed in the south countries. This epidemic is related to unhealthy eating patterns, decreased physical activity and increased inactivity.Objective: To determine the relationship between adiposity degree and physical activity and inactivity in children and adolescents.Methods: 338 children from 6 to 8 years of age (x=11.11 years);...

hrp0082p1-d3-53 | Bone (1) | ESPE2014

Bone Mineral Density Evaluation in Children with Gaucher Disease

Larroude Maria Silvia , Drelichman Guillermo , Cassinelli Hamilton , Richard Lucia , Ruiz Alba , Reicher Paola , Cuello Fernanda , Lanza Victoria , Fernandez Ramiro , Maro Alejandra , Corrales Marcela , Arizo Adriana , Escobar Nicolas Fernandez , Rapetti Cristina , Donato Hugo , Chain Juan Jose , Zirone Sandra , Cedola Alejandra , Bietti Julieta , Sweri Maia

Background: Bone involvement is described as a relevant sign in patients suffering Gaucher disease (GD).Objective and hypotheses: To analyze the long-term effect of enzyme replacement therapy on bone mineral density, a retrospective observational study was conducted in a cohort of 34 GD pediatric patients (14 males, 20 females, median age 11.3 years).Method: Lumbar spine (LS) (L2–L4, N: 34) and total body (TB) (N: 24) bone min...

hrp0089p3-p146 | Fat, Metabolism and Obesity P3 | ESPE2018

Does the Level of Studies of Parents Influence the Follow-up of the Recommendations of the Nutritional Pyramid?

Rosaura Leis Trabazo Maria , de Lamas Perez Carmela , Vazquez Cobela Rocio , Jose Bedoya Carpente Juan , Olza Meneses Josune , Gil Hernandez Angel , Alberto Moreno Aznar Luis , Bueno Lozano Gloria , Gil Campos Mercedes , Aguilera Garcia Concepcion

Introduction: Several studies show the negative impact of low level of studies of parents on the dietary patterns and the degree of adiposity of their children. The objective of this study is to evaluate the relationship between the level of studies and compliance with the recommendations of healthy eating pyramid.Material and method: An anthropometric study was conducted in 895 Spanish children and adolescents (53% women), between 3 and 18 years old (10...

hrp0086p1-p454 | Fat Metabolism and Obesity P1 | ESPE2016

Influence of Television Viewing During Meals on Eating Patterns

Leis Trabazo Rosaura , Vazquez-Cobela Rocio , Jose Bedoya Carpente Juan , Aguilera Garcia Concepcion , Olza Meneses Josune , Gil-Campos Mercedes , Bueno Lozano Gloria , Gil Hernandez Angel , Moreno Aznar Luis , Tojo Sierra Rafel

Background: Recent studies show negative impact of the use of television while having food on the eating patterns.Objective and hypotheses: Our goal is to use cluster analysis to evaluate this influence in children.Method: In 895 Spanish children and adolescents (47% male and 53% female), from 3 to 18 years of age (10.25±2.67 years), a validated food frequency and food consumption habits questionnaire (CFCA) is performed. Thre...

hrp0084p3-887 | Fat | ESPE2015

Sports Regulated and Lipid Profile in Children and Adolescents with Overweight

Trabazo Rosaura Leis , Cobela Rocio Vazquez , Garcia Concepcion Aguilera , Lozano Gloria Bueno , Meneses Josune Olza , Campos Mercedes Gil , Carpente Juan Jose Bedoya , Feijoo Lidia Castro , Aznar Luis Moreno , Hernandez Angel Gil

Introduction: Obesity is the most common nutritional disorder in the paediatric age. Decreased physical activity and increased inactivity are important factors that are involved in this pandemic. The highest prevalence of obesity in Europe is in the South.Objective: To study the relationship between the practice of a regulated sport and lipid profile in overweight children and adolescents.Material and methods: 318 overweight childr...