ESPE Abstracts

Introduction: To date, there are no clear indications for surgical treatment of nodular goiter in children. Current scheme of diagnostic evaluation thyroid nodules in children is not always justified. A number of patients either go to the removal of thyroid remnants when a carcinoma is found in the histological examination and the need for radioiodine therapy, or are at risk of surgery if the results of the final histology show that the disease is benign.<p class="abstext"...

Objective and hypotheses: To study the lipid metabolism in children with diabetes type 1.Method: It was included 44 children (33 girls), the average age – 10.2±3.3 years. Patients were divided: group 1 (less than 5 years) – 23 children (17 girls), mean age 9.8±3.6, the average length of diabetes 2.08±1.5 years. The second (over 5 years) – 21 children (16 girls), mean age of 11.6±2.4, the average length – 7.5±1...

Background and aims: To study the prevalence of metabolic syndrome and its components (impaired fasting and after overload glucose, type 2 diabetes mellitus, low cholesterol HDL, and high triglycerides) in children with obesity.Methods: This research includes 550 (65.8% boys) children, recruited from Pediatric Endocrinology Department, with abdominal obesity. We measured BMI, waist circumference, blood pressure with standard instrumentation and glucose (...

Objective: The aim of this study were to investigate the level of inhibin B and its relationship with testosterone, anti-Müllerian factor, basal, and GnRH-stimulated gonadotropin hormones (LH and FSH) concentration in boys with constitutional delay of puberty.Material and methods: In the study were included 15 boys (mean age 14.5±1.6 years) in Tanner stages 1–2. The investigation consists of genital examination with prader orchidometer, de...

Background: Disorders of sex development, especially with Y chromosome material, are the main factor of an increased risk of gonadal tumour. The main idea of this study was to investigate the prevalence of gonad tumours in patients with 46,XY gonadal dysgenesis.Methods: This study included 9 patients with 46,XY gonadal dysgenesis: seven patients with partial and two with total gonadal dysgenesis. Among nine patients there were two patients with Frasier s...

Introduction: One of the strategies of searching the genetic causes of CDGP is analysing the genes responsible for hypogonadotropic hypogonadism (HH).Objective: To investigate the role of the HS6ST1 gene in development CDGP.Materials and Methods: Two patients - height and BMI SDS, bone age, genitometric parameters, basal hormones, GnRH analogue test, hCG test, olfactometry, brain-M...

Background: The pathophysiology of type 2 diabetes mellitus (T2DM) is based on defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Young people have a more aggressive course of the disease. However, the impact and sequence of pathological mechanisms involved in the development of T2DM in adolescents hasn’t been established. Diagnosis of the prediabetes in time can be u...

Background: The increased prevalence of youth obesity has led to raised youth-onset type 2 diabetes mellitus (T2DM), as well as the intermediate condition of prediabetes. Diagnosis of prediabetes can help preventing of the development of T2DM.Aims: to study the frequency, clinical laboratory diagnostics and relationship of prediabetes with SDS BMI in obese adolescents.Materials: Th...

Objective of the research: To compare clinical laboratory and genitometric parameters in girls with hypogonadotropic hypogonadism (HH) and constitutional delayed puberty (CDP).Materials and Methods: 23 female patients with delayed puberty are included in the study.Inclusion criteria: Absence of secondary sexual characteristics at age ≥13 years or absence of menarche at age ≥1...

Introduction: Thyroid surgery in children is associated with high risk of recurrent laryngeal nerves (RLN) damage. It is due to complex and variable anatomy, high bleeding which decreasing visualization and requiring instrumental hemostasis. Large goiters change of syntopy, metastatic process requires bigger aggression and volume of intervention. The risk of damage significantly increases during repeated operations due to the scar process. There is significant...