hrp0084p3-1109 | Pituitary | ESPE2015

Acute Phase Proteins and Endocrine Dysfunction after Traumatic Brain Injury in Childhood

Verigaki Olga , Papassotiriou Ioannis , Prodromou Neofytos , Sfakianos George , Chrousos George , Kanaka-Gantenbein Christina

Background: Endocrine impairments, such as diabetes insipidus (DI), growth hormone deficiency (GHD) and, to a lesser degree, thyroid or cortisol deficiencies, have been reported after traumatic brain injury (TBI) in adults and much less in children both at the acute post-traumatic phase and after a lag period of time. However, no prospective data exist on the endocrine and acute phase protein response to TBI in childhood.Aim/objective: To unravel possibl...

hrp0094p2-401 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Two sisters with primary hypergonadotrophic hypogonadism, pubertal progress and deletion of 61.5MB of Χq21.33q28 region

Dikaiakou Eirini , Vlachopapadopoulou Elpis Athina , Papoulidis Ioannis , Manolakos Emannouil , Vakaki Marina , Michalacos Stefanos

Objective: To present the novel finding of hypergonadotropic hypogonadism, pubertal progress and molecular alterations in two sisters with variable phenotype.Case Presentation: Two Greek sisters were investigated. The eldest was referred for investigation of short stature, at the age of 9 and 5/12 years. There was no positive family history for short stature. Physical examination revealed no dysmorphic features, and she was prepubertal according to Tanne...

hrp0094p2-161 | Diabetes and insulin | ESPE2021

Not every obese child has type 2 Diabetes Mellitus

Koutaki Diamanto , Vourdoumpa Aikaterini , Vasilakis Ioannis-Anargyros , Sertedaki Amalia , Charmandari Evangelia , Paltoglou George ,

Background: Maturity onset Diabetes of the young (MODY) is a rare form of diabetes with specific features that distinguish it from diabetes mellitus type 1 (DM1) or type 2 (Dm2). Research studies suggest that 5% of subjects diagnosed with diabetes before the age of 45 years have MODY, with 80% of them having been incorrectly diagnosed as having DM1 or Dm2. Genetic testing my enable correct diagnosis and treatment, optimize glycemic contro...

hrp0098p2-295 | Thyroid | ESPE2024

Graves' Disease in Children and Adolescents: A 10 years’ retrospective analysis of patients followed in a Single Center

Gkougkouli Eleni , Dolianiti Maria , Vasilakis Ioannis-Anargyros , Sakka Sofia , Nikolaides Nicolas , Mpinou Maria , Kanaka Gantenbein Christina

Introduction: /Purpose: Graves' disease is the most common cause of hyperthyroidism in children and adolescents. It is an autoimmune disorder characterized by stimulating autoantibodies, leading to increased thyroid hormone release and thyrotoxicosis. Early initiation and long-term treatment, remission, and definitive treatment with thyroidectomy or radioactive iodine present a challenge. This study aims to record the data of patients with Graves' disease foll...

hrp0095p1-259 | Diabetes and Insulin | ESPE2022

Tear Proteomics in Children and Adolescents with Type 1 Diabetes Mellitus and Correlation with Cognitive Function Levels

Nicolaides Nicolas , Makridakis Manousos , Kitani Rosa-Anna , Letsou Konstantina , Kressou Evangelia , Angelopoulou Eleni , Vasilakis Ioannis-Anargyros , Kosteria Ioanna , Mantzou Aimilia , Papassotiriou Ioannis , Varvogli Liza , Zoidakis Jerome , Kanaka-Gantenbein Christina

Background: Several studies have shown that type 1 diabetes mellitus (T1DM) may contribute to the early onset or acceleration of cognitive impairment (intelligence, psychomotor efficiency, information management speed, visual attention, visual perception and cognitive flexibility). Tear proteomics seems to provide useful information for understanding the molecular mechanisms of various ocular and systemic diseases.Objective and H...

hrp0089p1-p127 | Fat, Metabolism and Obesity P1 | ESPE2018

PCSK9 and Lp(a) Levels of Children Born after Assisted Reproduction Technologies

Kosteria Ioanna , Terentes-Printzios Dimitrios , Koutagiar Iosif , Vlachopoulos Charalambos , Gkourogianni Alexandra , Sakka Sophia , Skoumas Ioannis , Miliou Antigoni , Papassotiriou Ioannis , Loutradis Dimitrios , Chrousos George P , Tousoulis Dimitrios , Kanaka-Gantenbein Christina

Background/Aims: Since the introduction of Assisted Reproduction Technologies (ART), including classic In Vitro Fertilization (IVF) and Intacytoplasmic Sperm Injection (ICSI), in clinical practice, several studies have addressed concerns regarding the long-term health of the offspring, revealing indications of an adverse cardiometabolic outcome. Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating level is significantly associated with an increased risk of cardiov...

hrp0082p3-d1-766 | Fat Metabolism & Obesity | ESPE2014

Positive Association of Pro-Oxidative Stress Markers with Adipose Mass in Pre- and Early-Pubertal Boys

Paltoglou George , Schoina Maria , Valsamakis George , Avloniti Alexandra , Chatzinikolaou Athanasios , Kambas Antonis , Draganidis Dimitris , Papassotiriou Ioannis , Margeli Alexandra , Salakos Nicolaos , Papagianni Maria , Kanaka-Gantenbein Christina , Chrousos George P , Fatouros Ioannis G , Mastorakos George

Background: Oxidative stress and adipocytokines are associated with obesity.Objective and hypotheses: To investigate the association of adipocytokines with markers of pro- and anti-oxidation at baseline and their change and correlations during acute aerobic exercise in normal weight and obese pre- and early-pubertal boys.Method: Fifty healthy pre- and early-pubertal, normal weight and obese boys, underwent a baseline blood sampling...

hrp0094p1-112 | Fat, Metabolism and Obesity B | ESPE2021

Evaluation of the BigO behavioral indicators in overweight and obese children and adolescents

Kassari Penio , Tragomalou Athanasia , Vourdoumpa Aikaterini , Koutaki Diamanto , Papadopoulou Marina , Manou Maria , Ioakeimidis Ioannis , Filis Konstantinos , Theodoropoulou Eleni , Lymperopoulos Giorgos , Ferri Daniel , Karavidopoulou Youla , Stefanopoulos Leandros , Sarafis Ioannis , Diou Christos , Lekka Eirini , Maglaveras Nicos , Delopoulos Anastasios , Charmandari Evangelia ,

Background: Obesity represents one of the most challenging public health problems of our century. According to the World Health Organization, there is a need to create reliable monitoring and behavioral systems, and to investigate their effectiveness in preventing childhood obesity.Objective: To evaluate the BigO behavioral indicators in a pediatric population in Greece.Methodology: The study was c...

hrp0095p1-436 | Diabetes and Insulin | ESPE2022

Association of the apoptotic markers Apo1/Fas and cCK-18 and the adhesion molecule ICAM-1 with Type 1 diabetes mellitus in children and adolescents.

Kostopoulou Eirini , Efthymia Katsa Maria , Ioannidis Anastasios , Foti Maria , Dimopoulos Ioannis , Spiliotis Bessie , Paola Rojas Gil Andrea

Introduction: Type 1 diabetes mellitus (T1DM) is characterized by insulin-producing pancreatic β-cells loss. Apo1/Fas, a glycosylated surface protein, is implicated in maintaining homeostasis of the immune system. Cytokeratin-18 (cCK-18) is a predictive marker of liver disorders in T2DM. Intercellular adhesion molecule-1 (ICAM-1) is considered a candidate gene for susceptibility to diabetes mellitus. Aim: To investigate the possible role of Apo1/Fas, cCK-...

hrp0092p1-118 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Whole Exome Sequencing (WES) Reveals Oligogenic Gene Mutations in a Case of Combined Pituitary Hormone Deficiency (CPHD)

Sertedaki Amalia , Tatsi Elizabeth-Barbara , Nikaina Eirini , Vasilakis Ioannis Anargyros , Fylaktou Irene , Iacovidou Nicoletta , Siahanidou Soultana , Kanaka-Gantenbein Christina

Introduction: CPHD is characterized by GH and at least one other pituitary hormone deficiency. Mutations in genes expressed in the developing head, hypothalamus, and/or pituitary cause CPHD. To date around 30 genes have been identified to be related to CPHD, however the 85% of the cases remain with unknown aetiology. Whole Exome Sequencing (WES) enables parallel searching for pathogenic variants of CPHD in targeted known gene panels as well as the identifi...