hrp0097p1-525 | Growth and Syndromes | ESPE2023

Human milk insulin-like growth factor-1 (HMIGF1) and its effects on Infantile and Childhood Growth

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Soliman Nada , Shaat Mona , Adel Ashraf

Introduction: Accumulating evidence indicates various but significant effects of human breast milk IGF1 (HMIGF1) on infantile linear growth and weight gain.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on various effects of HMIGF1 on infantile and childhood growth. We reviewed 12 studies (n= 941 inf...

hrp0097p2-47 | GH and IGFs | ESPE2023

The Interaction between Growth Hormone (GH) -Insulin-like Growth factor 1 (IGF1) axis and Immune Systems in Infants and Children During undernutrition: Newly Discovered Pathological mechanisms.

Soliman Ashraf , Alaaraj Nada , Rogol Alan , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Soliman Nada

Accumulating evidence indicates various interactions between the GH-IGF1 axis and the immune system in infants and children during undernutrition.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on the link between the GH-IGF1 axis and the immune system in infants and children during malnutrition. We reviewed 22 studies (2007-2...

hrp0097p2-136 | GH and IGFs | ESPE2023

Human milk insulin-like growth factors and Cyclic glycine-proline (cGP) concentrations in relation to infantile and childhood growth.

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Soliman Nada

Introduction: Insulin-like growth factor (IGF)-1, IGF binding proteins (IGFBPs) and regulatory metabolites, including cyclic Glycine-Proline (cGP), have a possible role in modifying infant growth trajectories through their effects on linear growth, and body composition. There is no consensus on how maternal BMI affects breast milk IGF1 level.Aim: We reviewed the recent literature about human milk (IGF)-1, and cGP concent...

hrp0097p2-5 | Growth and Syndromes | ESPE2023

Variations in body composition, IGF1 and Cyclic glycine-proline (cGP) concentrations in breastfed vs formula fed infants during infancy period.

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Soliman Nada , Shaat Mona

Introduction: Breastfeeding is one of the most effective preventive measures of childhood obesity and many other chronic diseases. The effect of breastfeeding vs formula feeding in changing infant`s body composition remains unclear.Aim and Methods: The objective of this review is to update and summarize the recent literature (Pubmed, Google scholar, Scopus and Research gate in the past 10 years) on studies investig...

hrp0097p2-6 | Growth and Syndromes | ESPE2023

Maternal, placental and fetal IGF-1 and IGFBP in Obese pregnancies and the effect on fetal/infantile growth

Soliman Ashraf , Hamed Noor , Ahmed Shyama , Alyafei Fawzia , Alaaraj Nada , Soliman Nada

Introduction: Placental hormones can control the transfer of maternal nutrients to the fetus and modulate fetal and neonatal growth. Data about the interaction between maternal, placental and fetal IGF1/IGFBP in relation to newborn size is not clear,Aim: To review research paper published in Pubmed, Google scholar, Research gate, and Scopus in the past 20 years on the relation between maternal, placental and fetal/infant...

hrp0097p2-194 | Growth and Syndromes | ESPE2023

Impact of Undernutrition and Short Stature on The Quality of Life (QOL) in Children and adolescents with Beta thalassemia Major (BTM)

Soliman Ashraf , Ahmed Shayma , Soliman Nada , Elalaily Rania , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Itani Maya

Introduction: Quality of life (QoL), comprises physical, psychological, environmental, and social aspects, is an index designed to measure the burden of chronic diseases and evaluate the treatment outcome. Thalassemia major (BTM) is a chronic disease in children that harms children QoL by interrupting physical function, emotional function, social function, and school function. ObjectivesAim: This study aims to identify t...

hrp0097p2-1 | Multisystem Endocrine Disorders | ESPE2023

Prevalence of Malnutrition and Underweight in Children and Adolescents with Beta-Thalassemia Major (BTM)

Soliman Ashraf , Yassin Mohamed , Alyafei Fawzia , Ahmed Shayma , Alaaraj Nada , Soliman Nada

Introduction: Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). Malnutrition affects the growth, efficacy of treatments, and quality of life in children suffering from BTM.Objective: To evaluate the prevalence of malnutrition (BMI < 3rd centile for age and sex) or BMISDS < -2 in 10 Mediterranean and Middle east countries and the USA in the past 20 years.  <p c...

hrp0097p2-87 | Multisystem Endocrine Disorders | ESPE2023

Undernutrition, abnormal body composition, and impaired linear growth in children and adolescents with Beta-Thalassemia Major: possible contributing factors

Soliman Ashraf , Ahmed Shayma , Alaaraj Nada , Elalaily Rania , Alyafei Fawzia , Hamed Noor , Soliman Nada

Introduction:Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). Malnutrition negatively affects their growth, efficacy of treatments, and quality of life.Objective: To evaluate the nutritional status and linear growth in 10 countries in the past 20 years.Methods: We performed an electronic search in PubMed, Google Scholar, and Web of Scie...

hrp0095p1-320 | Growth and Syndromes | ESPE2022

International vs Qatar national growth data for identifying small and large-for-gestational-age newborns: A population-based study in Qatar

Alyafei Fawzia , Soliman Ashraf , Alqubasi Mai , Ali Hamdy , Alturk Mohamed , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Background: To update the ongoing debate about the use of universal strict vs (local) national intrauterine growth charts, we compared the prevalence of small and large-for-gestational-age (SGA/LGA) infants according to international charts and national growth data.Methods: We classified singleton births from 33 to 42 weeks of gestation in 2016 and 2019 from Qatar (n = 92431), SGA (birthweight <10th percentil...

hrp0094p2-416 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Ovarian Juvenile Granulosa Cell Tumor in 9-Month-Old female Infant presented with Isosexual Pseudo Puberty: Case Report

Ahmed Shayma , Soliman Ashraf , Alaaraj Nada , Alyafie Fawzia , Maadheed Maryam AL , Clelland Colin

Background: In infants, less than 1-year JGCT is extremely rare, with very few reported cases in the literature.Case Report: This 9-month old girl, presented with a day history of bloody vaginal secretions, with an increase in breast size bilaterally 2 months before presentation and growth of fine hair in the genital area. She had no skin hyperpigmentation, no skeletal abnormalities, and no dysmorphic features. On examination, the girl had no dysmorphic ...