hrp0098p2-88 | Diabetes and Insulin | ESPE2024

Hypopituitarism following traumatic brain injury in children and adolescents - Long-term outcome study in a prospective patient cohort (2017-2023)

Matonti Lorena , Deodati Annalisa , Rapini Novella , Pampanini Valentina , Mariani Carlo , Elisa Amodeo Maria , Cianfarani Stefano , Schiaffini Riccardo

Background: Managing glucose control in young children with Type 1 Diabetes (T1D) is challenging due to variable insulin needs, sensitivity, and unpredictable eating and activity behaviours. Despite their effectiveness, the majority of the Advanced Hybrid Closed Loop (AHCL) systems is not approved for children under six in many countries of Europe.Aim: To assess and compare the effectiveness of Multiple Daily Injection (...

hrp0095p1-247 | Diabetes and Insulin | ESPE2022

Monogenic diabetes clinic: 3-year experience

Rapini Novella , Ippolita Patera Patrizia , Schiaffini Riccardo , Ciampalini Paolo , Pampanini Valentina , Cristina Matteoli Maria , Deodati Annalisa , Bracaglia Giorgia , Porzio Ottavia , Novelli Antonio , Mucciolo Mafalda , Cianfarani Stefano , Barbetti Fabrizio

Background: In Italy monogenic forms of hyperglycemia account for more than 6% of cases referred to pediatric diabetes clinics. In January 2019 we started a Monogenic Diabetes Clinic (MDC) with the three main aims: a) implementing a standardized pathway towards genetic testing, 2) ease the revision of complex cases, 3) implement standardized therapies for monogenic diabetes mellitus (MDM) subtypes.Methods: Type 1 diabete...

hrp0095p1-188 | Thyroid | ESPE2022

A case report of Hirschsprung Disease and C Cell Hyperplasia: a new RET gene variant?

d'Aniello Francesco , Ubertini Graziamaria , Mirra Giulia , Elisa Amodeo Maria , Deodati Annalisa , Daniela Iacobelli Barbara , Agolini Emanuele , De Vito Rita , Grossi Armando , Cappa Marco

We report and discuss a case of a girl who at birth underwent surgery for Hirschsprung Disease (HD). To closely investigate her condition, we used a Next Generation Sequencing (NGS) panel to carry out a study of some of the genes known as being associated with congenital megacolon (PHOX-2B, RET, EDN3, GDNF, ASCL1 and BDNF). This analysis showed a maternally inherited heterozygous variant in the RET protooncogene (c.734T>A, p.Val245Glu), which is not described in the scienti...

hrp0092rfc2.4 | Bone, Growth Plate and Mineral Metabolism Session 1 | ESPE2019

Bone Mass and Fracture Prevalence in Childhood Brain Cancer Survivors 2, 5 or 7 Years After Off Therapy

Gallizia Annalisa , Mauro Vera , Crocco Marco , Elsa Maria Allegri Anna , Napoli Flavia , Luisa Garrè Maria , Maghnie Mohamad , Di Iorgi Natascia

Background and Aim: Multifaceted risk factors impair bone mass (BM) in childhood brain cancer survivors(CBCS). Aims of the study were to evaluate bone mass and it's determinant and fracture prevalence in CBCS 2(G+2), 5(G+5) or 7(G+7) years after off therapy (OT).Methods: Seventy-three(G+2), 87(G+5) and 66(G+7)CBCS were evaluated at 12,9±4,2, 14,9±4,4 and 16,6±4,4yrs, respectivel...

hrp0092p1-58 | Fat, Metabolism and Obesity | ESPE2019

A Case-Control Study of Exposure to Bisphenol-a and Phthalates in Obese Children

Deodati Annalisa , Bottaro Giorgia , La Rocca Cinzia , Tait Sabrina , Maranghi Francesca , Tassinari Roberta , Busani Luca , Carli Fabrizia , Latta Veronica Della , Buzzigoli Emma , Gastaldelli Amalia , Cianfarani Stefano

Background: The increasing incidence of obesity is a serious global public health challenge. Endocrine disrupting chemicals (EDCs) are exogenous chemicals that interfere with the endocrine system, including adipose tissue. Increasing evidence from epidemiological, animal, and in vitro studies shows that EDCs, in particular bisphenol A (BPA) and phthalates (e.g. di-ethyl-hexyl-phthalate, DEHP), can affect body weight, adipogenesis and circulating lipid profile,...

hrp0092p1-260 | Pituitary, Neuroendocrinology and Puberty (1) | ESPE2019

A Case-Control Study of Exposure to Bisphenol-A and Phthalates in Girls with Early Onset of Puberty

Deodati Annalisa , Bottaro Giorgia , La Rocca Cinzia , Tait Sabrina , Maranghi Francesca , Tassinari Roberta , Busani Luca , Carli Fabrizia , Latta Veronica Della , Buzzigoli Emma , Gastaldelli Amalia , Cianfarani Stefano

Background: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. Several factors including genetic predisposition, psychosocial and socio-economic conditions, diet and ethnicity may have contributed to this phenomenon. Epidemiological and animal studies have shown that the exposure to BPA and DEHP may be associated with early onset of puberty in girls.Objective: To investigate...

hrp0089p1-p025 | Bone, Growth Plate & Mineral Metabolism P1 | ESPE2018

Intrauterine Growth Restriction, Antenatal Steroids, Gestational Age and Breast Feeding Influence Bone Health in Prepubertal Children Born Preterm

Iorgi Natascia Di , Calcagno Annalisa , Diana Paola , Notarnicola Sara , Allegri Anna Maria Elsa , Napoli Flavia , Cangemi Giuliana , Calevo Mariagrazia , Ramenghi Luca , Maghnie Mohamad

Objectives: To assess the long-term impact of prematurity on bone and body composition by using Dual-energy X-ray absorptiometry (DXA).Methods: DXA scans were performed in 100 preterm (PT) (n=42F, n=58M, mean weeks’gestation 31.5±2.6; range 26−36) and 51 born at term (BT) healthy infants (n=28F, n=23M). DXA measures of total body and lumbar spine mineral density (TB/L1-L4 BMD, g/cm2 and Z...

hrp0089p2-p126 | Fat, Metabolism and Obesity P2 | ESPE2018

Serum Calprotectin Level in Children: Marker of Obesity and Its Metabolic Complications

Calcaterra Valeria , Amici Mara De , Silvestri Annalisa De , Michev Alexandre , Montalbano Chiara , Regalbuto Corrado , Schiano Luca Maria , Cena Hellas , Larizza Daniela

Aim: Circulating levels of calprotectin have been reported in obesity-related chronic low-grade inflammation in adults, but has not been evaluated in pediatric population. We investigated serum calprotectin in overweight and obese children and its association with metabolic comorbidities.Methods: We enrolled 131 children (11.7±4.1 years). According to BMI, the subjects were divided into three groups: obese >95th percentile; overweight BMI 75th&#...

hrp0089p3-p128 | Fat, Metabolism and Obesity P3 | ESPE2018

Exposure to Bisphenol-A and Phtalates in Obese Girls

Deodati Annalisa , Bottaro Giorgia , Fintini Danilo , Tait Sabrina , Maranghi Francesca , Busani Luca , Rocca Cinzia La , Tassinari Roberta , Carli Fabrizia , Latta Veronica Della , Buzzigoli Emma , Gastaldelli Amalia , Cianfarani Stefano

Background: The increasing incidence of obesity is a global public health challenge. Although energy imbalance is the major cause of obesity, evidence suggests that other risk factors such as exposure to endocrine-disrupting chemicals (EDCs) may contribute to the development of obesity. Early life exposure to obesogens may result in a higher risk of developing obesity. Among the chemicals suspected to have obesogenic effects, bisphenol A (BPA) and phthalates are under worldwid...

hrp0089p1-p209 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Exposure to BPA and Phthalates and Timing of Puberty in Girls

Deodati Annalisa , Bottaro Giorgia , Tait Sabrina , Maranghi Francesca , Busani Luca , Rocca Cinzia La , Tassinari Roberta , Carli Fabrizia , Latta Veronica Della , Buzzigoli Emma , Gastaldelli Amalia , Cianfarani Stefano

Background: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. Exposure to endocrine disrupting chemicals (EDCs) during critical windows of development may play a role in this trend. Epidemiological and animal studies showed that exposure to phthalates and BPA could be associated with earlier puberty onset in girls.Objective: To investigate the association between the exposure to BPA, DEHP’s metabolites...