hrp0098p3-125 | GH and IGFs | ESPE2024

Impact of Sex Steroid Priming on Growth Hormone Stimulation in Children with Short Stature: A Comparative Study"

Alyafei Fawzia , Hamed Noor , Alaaraj Nada , Elsayed Nagwa , Qusad Mohamed , Soliman Ashraf

Introduction: Growth hormone (GH) deficiency in children with short stature poses significant diagnostic and therapeutic challenges. Sex steroid priming before GH stimulation tests (GHST) is a strategy employed to enhance the diagnostic accuracy for GH deficiency. However, the efficacy and impact of this approach remain subjects of debate.Aim: This study aim ed to evaluate the effects of sex steroid priming on various gr...

hrp0098p3-128 | GH and IGFs | ESPE2024

Enhancing Diagnostic Accuracy in Growth Hormone Deficiency: A Comparative Analysis of Sex Steroid Priming in Pediatric Short Stature

Alyafei Fawzia , Soliman Ashraf , Qusad Mohamed , Hamed Noor , Alaaraj Nada , Ahmed Shayma , Elsayed Nagwa , Elsiddig Sohair

Introduction: This study presents a comparative analysis of the efficacy of sex steroid priming in enhancing growth hormone (GH) responses in short stature children undergoing GH stimulation tests.Methods: A randomized study encompassed a cohort of 40 children, divided into two groups: "With Priming" and "Without Priming". The primed group exhibited a higher peak GH response (6.53) compared to the non...

hrp0098rfc5.6 | Growth and Syndromes | ESPE2024

Pubertal induction in girls with Turner syndrome – retrospective data from the International TS registry

Gawlik-Starzyk Aneta , Matthews Debbie , Błaszczyk Ewa , Brain Caroline , Öhman Kriström Berit , M McGlacken-Byrne Sinéad , Sas Theo , van der Velden Janielle , Verlinde Franciska , Wasniewska Malgorzata , Smith Arlen , Gawlik Jakub , Atapattu Navoda , Bertelloni Silvano , Binder Gerhard , Cheetham Tim , L Claahsen-van der Grinten Heidi , M O'Connell Susan , Cools Martine , Dirlewanger Mirjam , Elsedfy Heba , A Baky Fahmy Mohamed , Fica Simona , E. Flück Christa , F Gevers Evelien , Globa Evgenia , Guazzarott Laura , Guven Ayla , E. Hannema Sabine , Herrmann Gloria , Howard Sasha , Iotova Violeta , Januś Dominika , Konrad Daniel , Krone Nils , Kyrilli Aglaia , Leka-Emiri Sofia , Marginean Otilia , Markosyan Renata , Niedziela Marek , Nordenstrom Anna , Obara - Moszynska Monika , Poyrazoglu Sukran , Probst Ursina , Rohayem Julia , Russo Gianni , Šandrk Beslać Marija , Schwitzgebel Valerie , Nimali Seneviratne Sumudu , Shenoy Savitha , Starzyk Jerzy , Tourlamain Gilles , Lenherr Taube Nina , Ucar Ahmet , Utari Agustini , Wędrychowicz Anna , Wojtyś Joanna , Zainaba Mohamed , Bryce Jillian , Chen Minglu , Koley Sanhita , Alimussina Malika , N.S. Matthews John , Faisal Ahmed Syed , D.C. Donaldson Malcolm

Background: Current guidelines for girls with gonadal dysgenesis due to Turner Syndrome (TS) recommend initiating estrogen therapy at 11-12 years of age, using 'natural' 17-β estradiol. However, there is scant evidence regarding the optimal modality of induction, particularly concerning whether oral or transdermal routes are more effective or acceptable.Aim: To retrospectively evaluate differences in puber...

hrp0092p2-11 | Adrenals and HPA Axis | ESPE2019

Long-term Prednisone versus Hydrocortisone Treatment in Children with Classic Congenital Adrenal Hyperplasia (CAH): A Controlled Study

Soliman Ashraf Tawfik , Abdel Meguid Ahmed Shayma Elsayed , Ramadan Magdy , Elawwa Ahmed , Said Abugabal Ahmed Mohamed , Ahmed Emam Mohamed Hassan

Background: Debate still exists about the safety of long-term use of prednisone (PD) versus hydrocortisone (HC) for treating children with CAH. Relatively slight supraphysiologic levels may be enough to blunt growth velocity, increase weight gain.Objectives of the study: We evaluated the anthropometric and biochemical effects of long-term PD versus HC treatment in children with CAH-21OHD.<p class="ab...

hrp0086rfc9.8 | Pathophysiology of Disorders of Insulin Secretion | ESPE2016

Micro RNA and Diabetic Nephropathy

Abdelghaffar Shereen , Elmougi Fatma , Abdelaty Sahar , Elshiwy Yasmin , Elsayed Reham , Abdelrahman Heba , Mehawed Hend , Elgebaly Heba , Ahmed Sakinatalfouad , Elalfy Peter

Background: MicroRNAs (miRNAs) are short non-coding RNAs that repress target gene expression via post-transcriptional mechanisms.Objective and hypotheses: To study the expression of miRNA-25, miRNA-216, miRNA-21, miRNA-93, miRNA-377 in a sample of 100 type 1 diabetic patients with and without microalbuminuria to probe their role in development of diabetic nephropathy.Methods: Hundred type 1 diabetic patients, 50 with microalbuminur...

hrp0098p2-257 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2024

Clinical and Laboratory Characteristics of Children with Congenital Adrenal Hyperplasia (CAH): A Comparative Study of Hypertensive and Normotensive Patients

Elsayed Shayma , Tawfeek Soliman Ashraf , Elawwa Ahmed , Alaa ElDin Thabet Mohamed , Marzouk Iman , Elneely Dalia , Diab Dina

Background: Hypertension is a recognized complication in children with Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency, treated with glucocorticoids and mineralocorticoids. This study aims to compare the clinical and laboratory characteristics of children with CAH who developed hypertension with those who maintained normal blood pressure (BP) over a treatment course.Methods: This retrospective cohor...

hrp0098p2-258 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2024

Impact of Precocious Puberty on Clinical Management in Pediatric Patients with Congenital Adrenal Hyperplasia

Elsayed Shayma , Taweek Soliman Ashraf , Elawwa Ahmed , Alaa Eldin Thabet Mohamed , Marzouk Iman , Elneely Dalia , Diab Dina

Background: Congenital Adrenal Hyperplasia (CAH) is a complex endocrine condition with varying presentations, one of which includes precocious puberty. Understanding how precocious puberty affects clinical parameters in pediatric CAH patients is crucial for optimizing management strategies.Methods: This study conducted a comprehensive statistical analysis comparing pediatric CAH patients with precocious puberty (n</e...

hrp0098p3-235 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2024

Comparative Analysis of Clinical Presentation and Hormonal Profiles in Egyptian Pediatric Patients with 11-Beta-Hydroxylase and 21-Hydroxylase Deficient Congenital Adrenal Hyperplasia

Diab Dina , Alaa El-Din Thabet Mohammed , Mohamed Marzouq Iman , Elneely Dalia , Tawfeek Soliman Ashraf , Elawwa Ahmed , Elsayed Shaymaa

Introduction: Congenital Adrenal Hyperplasia (CAH) encompasses a spectrum of genetic disorders resulting from enzyme deficiencies that impair adrenal steroidogenesis. The most common forms are due to 21-hydroxylase and 11-beta-hydroxylase deficiencies, each presenting with distinct clinical and hormonal profiles.Aim: This study aims to compare the clinical presentations and laboratory findings in Egyptian pediatric patie...

hrp0098p3-236 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2024

Comparative Analysis of Growth and Hormonal Parameters in Pediatric Patients with 11-Beta-Hydroxylase Deficiency (11OHD) vs. 21-Hydroxylase Deficiency (21OHD)

Diab Dina , Alaa El-Din Thabet Mohammed , Marzouq Iman , Elneely Dalia , Tawfeeq Soliman Ashraf , Elawwa Ahmed , Elsayed Shymaa

Background: Congenital Adrenal Hyperplasia (CAH) is characterized by various enzyme deficiencies, notably 11-Beta-Hydroxylase Deficiency (11OHD) and 21-Hydroxylase Deficiency (21OHD), each affecting growth and hormonal levels differently. This study aim ed to compare the anthropometric and hormonal profiles of pediatric patients affected by these two conditions.Methods: The clinical records of pediatric patients diagnose...

hrp0082p3-d3-914 | Pituitary (1) | ESPE2014

The Influence of Specimen pH on Urinary LH and FSH by Immunochemiluminometric Assays

Ma Ya-Ping , Xu Zhuang-Jian , Hu Yu , Zhu Wen-Ying , Wang Qing

Background: It remains unclear whether specimen pH can influence urinary LH and FSH assayed by immunochemiluminometric assays (ICMA).Objective and hypotheses: To investigate the effect of specimen pH on urinary LH and FSH assayed by ICMA.Method: The first morning-voided urine were collected and divided into 11 samples (each 100 ml). The urine pH was determined with a pH meter. Hydrochloric acid and sodium hydroxide were added to al...