Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 3

Pituitary (1)

hrp0082p3-d3-912 | Pituitary (1) | ESPE2014

Screening for SOX2 Mutations in Bulgarian Patients with Congenital Hyposomatotropism: First Results

Aroyo Ani , Stoeva Iva , Dacheva Daniela , Kaneva Radka , Mitkova Atanaska , Oscar Alexander , Haikin Vassil , Mitev Vanio

Background: The transcription factor (TF) SOX2 is expressed early in the embryological development and is essential for the development of many structures like neural system, pituitary gland, eyes, ears, esophagus, and gonads. The most common clinical manifestations of mutations in the SOX2 gene are eye abnormalities (anophthalmia/microphthalmia, coloboma, nystagm, and refractive errors) and hypopituitarism (deficiency of gonadotropic, GH, TSH, and ACTH). Molecular genetic stu...

hrp0082p3-d3-913 | Pituitary (1) | ESPE2014

Follow Up for Adult Height of Girl with the Onset of Puberty at 6 or 7 Years Old

Xu Zhuang-Jian , Ma Ya-Ping , Zhao Jin-Ling , Zhang Jian-Mei , Xia Bing-Yang

Background: It is not yet clear whether the adult height (AH) is affected by the onset of puberty at 6 or 7 years old in girl in China.Objective and hypotheses: To evaluate AH in girl with the onset of puberty at 6 or 7 years old.Method: The standard of AH in girl was considered that their bone ages were equal to (or greater than) 15 years old or they were at least 3 years post-menarche. Eighty-two girls with the onset of puberty a...

hrp0082p3-d3-914 | Pituitary (1) | ESPE2014

The Influence of Specimen pH on Urinary LH and FSH by Immunochemiluminometric Assays

Ma Ya-Ping , Xu Zhuang-Jian , Hu Yu , Zhu Wen-Ying , Wang Qing

Background: It remains unclear whether specimen pH can influence urinary LH and FSH assayed by immunochemiluminometric assays (ICMA).Objective and hypotheses: To investigate the effect of specimen pH on urinary LH and FSH assayed by ICMA.Method: The first morning-voided urine were collected and divided into 11 samples (each 100 ml). The urine pH was determined with a pH meter. Hydrochloric acid and sodium hydroxide were added to al...

hrp0082p3-d3-915 | Pituitary (1) | ESPE2014

Thickened Pituitary Stalk with Central Diabetes Insipidus: What Diagnosis?

Merazka Amel , Samia Achir , Ouidad Baz , Dalila Foudil , Mourad Semrouni

Background: Central diabetes insipidus (DIC) is usually the final result of lesions affecting the hypothalamic–neurohypophyseal system, for the children, germinoma is the main reason. The MRI aspect is often limited to thickness pituitary stalk with loss of hyperintensity of the neurohypophysis.Objective and hypotheses: Thickening of pituitary stalk is suggestive of germinoma, the clinical picture is dominated by a DIC (90%), associated to hypopitui...

hrp0082p3-d3-916 | Pituitary (1) | ESPE2014

Polyuria Syndrome Associated with Visual Disorders in Children: Discuss at First Craniopharyngioma, the Primary Polydypsia is an Exclusion Diagnosis

Yacine Rahem , Merouane Belacel , Samia Achir

Background: True diabetes insipidus (DI) is a rare disease in children, defined as the excretion of hypotonic urine and polydypsia, secondary to an absolute or relative deficiency of antidiuretic hormone arginine vasopressin (central DI) or a resistance to the action of this hormone (nephrogenic DI). To differentiate from primary polydypsia.Objective and hypotheses: We report the case of AM a 13 years old girl, with personal history of cholecystectomy at...

hrp0082p3-d3-917 | Pituitary (1) | ESPE2014

Multiple Pituitary Hormone Deficiency with Transitory Pituitary Enlargement due to Prop1 Mutation (Case Presentation)

La Grasta Sabolic Lavinia , Stipancic Gordana , Pozgaj Sepec Marija

Background: In pediatric patients multiple pituitary hormone deficiency (MPHD) can be caused by mutations in pituitary-specific transcription factors. Among those, mutations in PROP1 gene account for ~50% of genetically determined cases of CPHD. Regarding morphology, the anterior pituitary can be normal, hypo-/aplastic or enlarged.Results: We present two unrelated patients referred for evaluation of growth retardation. Both had profound growth retardatio...

hrp0082p3-d3-918 | Pituitary (1) | ESPE2014

MRI in Children with GH Deficiency

Baz Ouidad , Semrouni Mourad , Sakher Samia , Chouikrat Nadia , Benallegue Mourad

Background: Magnetic resonance imaging (MRI) is advisable in all patients with GH deficiency (GHD). MRI pituitary morphology has important clinical implications, both in terms of diagnostic accuracy and long-term prognosis; indeed, when MRI findings are appropriately interpreted, they clearly represent a gold standard to investigate the etiology of GHD.Objective and hypotheses: To evaluate frequency and type of MRI anomalies in children with GHD, after d...

hrp0082p3-d3-919 | Pituitary (1) | ESPE2014

Dynamic Stimulation Testing in Pediatric Endocrinology: Experience of a Pediatric Endocrine Unit in a Developing Country

Sundaram Janani , Prasad Hemchand Krishna , Murugesan Gnanabalan , Vasudevan Ravisekar , Sangaralingam Thangavelu

Background: Basal or unstimulated hormone levels frequently do not provide sufficient diagnostic information in the investigation of endocrine disorders. A range of dynamic or provocative tests are available to assess the dynamic responses of hormones and make necessary diagnoses.Objective and hypotheses: To describe the experiences with dynamic stimulation testing of a Paediatric Endocrine Unit in a developing country.Method: Retr...

hrp0082p3-d3-920 | Pituitary (1) | ESPE2014

A Case of Hypopituitarism Caused by Traumatic Brain Injury in Infancy

Higuchi Shinji , Nishina Noriko , Takagi Masaki , Hasegawa Yukihiro

Background: While reports of hypopituitarism resulting from traumatic brain injury are increasingly common in European countries, long-term clinical courses are scarcely documented. We here present Japanese 31-year-old case with hypopituitarism caused by traumatic brain injury at the age of 5 months.Objective and hypotheses: To clarify the evolution of clinical and endocrinological data for 30 years in this patient. We hypothesize that the evolution prog...

hrp0082p3-d3-921 | Pituitary (1) | ESPE2014

Severe Features of Central Hypothyroidism und Hypoadrenalism Effectively Resolved by Treatment with Somatropin in a Boy with Panhypopituitarism

Simic-Schleicher Gunter

Background: A case of hypopituitarism usually related to hypothyroidism and hypoadrenalism. The unexpected effect of somatropin treatment is reported presented with clinical signs.Method and results: A 4-year-old adynamic boy in a wheel chair with normal height (105 cm, −0.7 SDS) but low weight (13 kg) and reduced TSH and thyroid hormones was transferred for further endocrine evaluation. Born after twin pregnancy in 35 weeks (2780 g, 49 cm, and 34 ...

hrp0082p3-d3-922 | Pituitary (1) | ESPE2014

A Case of Combined Pituitary Hormone Deficiency (CPHD) due to Anterior Pituitary Hypoplasia

Kvaratskhelia Ekaterine , Rekhviashvili Maia , Metreveli David , Willig Rolf Peter

Background: Multiple anterior pituitary hormone deficiency (MPHD) may present in the newborn period or in early infancy with hypoglycemia, prolonged cholestatic jaundice micropenis, undescended testes due to GH, ACTH, and LH deficiency. Central hypothyroidism is becoming manifest later, less severe than primary hypothyroidism, usually without intellectual impairment. A male patient was admitted to our clinic with severe short stature at the age of 2 years, born with normal len...

hrp0082p3-d3-923 | Pituitary (1) | ESPE2014

Think Histiocytosis X Facing Insipidus Diabetes with Thickened Pituitary Stalk

Lichtenberger-Geslin Lydia , Gourmel Antoine , Sainte-Rose Christian , Trifunovic-Bony Helene , Braun Karine , Boudailliez Bernard , Devoldere Catherine

Background: Insipidus diabetes is a rare disease in pediatric endocrinology.Objective and hypotheses: Facing a thickened pituitary stalk on MRI pituitary, the main diagnosis to mention are: dysgerminoma, histiocytosis, sarcoidosis, and autoimmune hypophysitis. Histiocytosis is a rare and often underdiagnosed cause.Method: We report the case of a teenage girl who presented polyuria–polydipsia syndrome at the age of 14 years con...