Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 3

Puberty and Neuroendocrinology

hrp0082p3-d1-924 | Puberty and Neuroendocrinology | ESPE2014

Leptin Levels in Boys with Pubertal Gynecomastia

Buyukgebiz Atilla , Dundar Bumin , Dundar Nihal , Bober Ece

Background: It has been reported that there is a relationship between circulating leptin and sex steroid hormones and leptin is able to stimulate estrogen secretion by increasing aromatase activity in adipose stromal cells and breast tissue. Leptin receptors have been also shown in mammary epitheleal cells and it has been suggested that leptin is involved in the control of the proliferation of both normal and malignant breast cells.Objective and hypothes...

hrp0082p3-d1-925 | Puberty and Neuroendocrinology | ESPE2014

The Timing and Evolution of Puberty in a Sample of School-Aged Children in a Brazilian City

Feibelmann Taciana Carla Maia , da Silva Adriana Paula , Silva Daniela Cristina , de Resende Elisabete Aparecida Mantovani Rodrigues , Scatena Lucia Marina , de Fatima Borges Maria

Background: The beginning and evolution of physiological puberty may be occurring earlier, resulting in change in the age at which clinical investigation on precocious puberty must be conducted, as well as concerns regarding the possible deleterious effects of hormone exposure in a later stage of life.Objective and hypotheses: Assess age of beginning and evolution of puberty in boys and girls acknowledging the age of thelarche (T), menarche (M), period b...

hrp0082p3-d1-926 | Puberty and Neuroendocrinology | ESPE2014

The Significance of GnRH Stimulation Test, Leptin, and Pelvic Ultrasound Findings for Differentiating Idiopathic Central Precocious Puberty from Premature Telarche

Ersoy Betul , Yazici Pinar , Onur Ece , Ozkol Mine

Background: We aimed to investigate the differences of serum leptin, gonadotropin hormones levels on GnRH stimulation test, and pelvic ultrasound (US) findings between girls with idiopathic central precocious puberty (ICPP) and premature telarche (PT). Additionally, we aimed to determine correlations between leptin and other parameters.Method: Thirty-nine girls who had the breast budding before the age of 8 years and 19 healthy age-matched pre-pubertal g...

hrp0082p3-d1-927 | Puberty and Neuroendocrinology | ESPE2014

Basal LH Combined with the Tanner Stage of Breast Development can Predict the Gonadotropin Response Following GnRH Stimulation Test

Admoni Osnat , Schwartz Naama , Tenenbaum-Rakover Yardena

Background: The GnRH stimulation test is widely used in the evaluation of precocious puberty but it requires repeated blood sampling, time-consuming and uncomfortable for the patients.Objective and hypotheses: To identify which parameters can be used to predict pubertal response in GnRH stimulating test for the diagnosis of central precocious puberty (CPP) in girls.Method: Included in the study 123 girls aged 3–9 years that un...

hrp0082p3-d1-928 | Puberty and Neuroendocrinology | ESPE2014

Characteristics of Children Treated with Leuprolide Acetate

Karabulut Gulcan Seymen , Yuksel Aysegul , Ozsu Elif , Mutlu Gul Yesiltepe , Cizmecioglu Filiz Mine , Hatun Sukru

Objective: This study aims to reveal clinical, hormonal and ultrasound imaging features of patients treated with leuprolide acetate for diagnosis of precoccious puberty.Design: Retrospective analysis of patients with a diagnosis of central precoccious puberty and treated with leuprolide acetate between January 2008 and January 2013.Patients: 81 girls and two boys with early signs of puberty.Results: There was...

hrp0082p3-d1-929 | Puberty and Neuroendocrinology | ESPE2014

Long-Term Consequences of Indirect Topical Exposure to Testosterone Gel in Young Children

Gies Inge , Vanbesien Jesse , De Brucker Yannick , Ernst Caroline , Anckaert Ellen , De Schepper Jean

Background: Virilization of young children after topical androgen use by their fathers through skin contact is well-known. The long-term consequences of such exposure at very young age are not well known.Objective and hypotheses: The aim is to report the occurrence of spermarche in a young boy and central precocious puberty in a young girl as late consequences of interpersonal transfer of testosterone gel.Method: Testosterone conta...

hrp0082p3-d1-930 | Puberty and Neuroendocrinology | ESPE2014

Final Height in Girls with Idiopathic Central Precocious Puberty Treated with GNRH Analog: Comparison with Untreated Controls

Atay Zeynep , Abali Saygin , Guran Tulay , Haliloglu Belma , Bas Serpil , Turan Serap , Bereket Abdullah

Background: Studies evaluating the gain in final height in patients with idiopathic central precocious puberty (ICPP) report variable outcomes and mostly lack comparison with untreated controls.Objective and hypotheses: To compare the final height of ICPP patients treated with GnRH analog with and untreated control group.Method: 48 girls with ICPP treated with GnRH analog and 52 untreated girls with ICCP (due to late referral or re...

hrp0082p3-d1-931 | Puberty and Neuroendocrinology | ESPE2014

X-Linked Recessive Form of Nephrogenic Diabetes Insipidus in a 7-Year-Old Boy

Janchevska Aleksandra , Tasic Velibor , Krstevska-Konstantinova Marina , Cheong Hae Il

Background: Nephrogenic diabetes insipidus (NDI) is caused by inability of renal collecting duct cells to respond to arginine vassopresin (AVP)/antidiurethic hormone (ADH).Objective and hypotheses: The majority of patients (about 90%) have type 1, X-linked recessive form, of NDI caused by mutation in gene encoding the vassopresin V2 receptor. Type 2, autosomal NDI, have the rest 10% of patients. This type is caused by the aquaporin-2 water channel (AQP2)...

hrp0082p3-d1-932 | Puberty and Neuroendocrinology | ESPE2014

Idiopathic Hypogonadotropic Hypogonadism due to a GNRH1 Mutation

Ucakturk Eda Mengen , Kotan Leman Damla , Gurbuz Fatih , Yuksel Bilgin , Topaloglu Ali Kemal

Background: Idiopathic hypogonadotropic hypogonadism may be normosmic (nIHH) or it may be associated with anosmia, which is known as Kallmann syndrome (KS). First mutation GNRH1 was described in 2009 in patients with nIHH. Mutations of the human GNRH1 gene are a very rare cause of nIHH, with only six mutations so far described.Case: The proband is a 11.3-year-old boy who first presented at age 1 with micropenis and cryptorchidism. His p...

hrp0082p3-d1-933 | Puberty and Neuroendocrinology | ESPE2014

Effect on BMI of GnRH Analogue Treatment in Central Precocious Puberty or Early and Fast Puberty Girls

Qiuli Chen , Zhe Su , Yanhong Li , Huamei Ma , Hongshan Chen , Jun Zhang , Minlian Du

Objective: We assessed in a retrospective unicenter study the effect on BMI of treatment with GnRH analogs (GnRHa) in central precocious puberty (CPP) or early and fast puberty (EFP) girls.Methods: The BMI of 318 girls (227 CPP and 91 EFP) who treated with GnRHa alone were analyzed. Among them 89 were followed up to their final adult hight (FAH).Results: Before GnRHa treatment started, the girls with CPP and EFP had a mean BMI SDS ...

hrp0082p3-d1-934 | Puberty and Neuroendocrinology | ESPE2014

An Unusual Combination of Premature Ovarian Failure and a History of GNRH Treatment for Idiopathic Precocious Puberty

Parpagnoli Maria , Seminara Salvatore , Anzilotti Giulia

Background: The normal recovery of the hypothalamic–pituitary–gonadal axis after discontinuation of therapy with GNRH analogue for precocious puberty has been proven and documented in the last decades. There has been no report in the literature of patients in which a history of GNRH treatment of precocious puberty is correlated with premature ovarian failure.Objective and hypotheses: The aim of the authors is to evaluate the possibility of a co...

hrp0082p3-d1-935 | Puberty and Neuroendocrinology | ESPE2014

An Unusual Case of Early and Accelerated Puberty

Scalini Perla , Stagi Stefano , Pelosi Paola , Ricci Franco , Anzillotti Giulia , Greco Paolo Del , Seminara Salvatore , de Martino Maurizio

Background: Unlike precocious puberty, early and/or fast puberty have been less studied, despite the fact that this disorder may be associated to an organic lesion at CNS level.Objective and hypotheses: We illustrate a case of early and fast puberty in a girl with an occult intra-cranial tumor.Method: The girl was the first child of non-consanguineous, Italian parents. The family had a positive history of early puberty. Target heig...

hrp0082p3-d1-936 | Puberty and Neuroendocrinology | ESPE2014

Association of Van Wyk Grumbach and Debre Semelaigne Syndromes in Two Cases with Severe Hypothroidism

Demirel Fatma , Oden Alkim , Tayfun Meltem , Ucakturk Ahmet , Gungor Ali

Background: Van Wyk Grumbach (VWG) and Kocher Debre Semelaigne (KDS) syndromes are rare syndromes with clinical manifestation of hypothyroidism associated with precious pseudo puberty and myopathic pseudomuscular hypertrophy. We present two cases that have the characteristic of both VWGS and KDSS syndromes developed in association with a long-term untreated hypothyroidism.Case 1: Seventeen years old girl was referred to our hospital due to menstrual irre...

hrp0082p3-d1-937 | Puberty and Neuroendocrinology | ESPE2014

Van Wyk Grumbach Syndrome: Case Report from Georgia

Paghava Irakli

Background: Association of hypothyroidism, isosexual precocious puberty and macrogonadism was first described by Van Wyk Grumbach in 1960. Van Wyk Grumbach syndrome (VWGS) was reported predominantly in females, precocious puberty and clinical picture of hypothyroidism being the clinical hallmarks.Objective and hypotheses: Publishing additional data on clinical and hormonal spectrum of VWGS, providing for better understanding of its pathology and primary ...