ESPE Abstracts (2014) 82 P-D-3-1-926

The Significance of GnRH Stimulation Test, Leptin, and Pelvic Ultrasound Findings for Differentiating Idiopathic Central Precocious Puberty from Premature Telarche

Betül Ersoya, Pinar Yazicia, Ece Onurb & Mine Ozkolc


aDivision of Pediatric Endocrinology and Metabolism, School of Medicine, Celal Bayar University School of Medicine, Manisa, Turkey; bDivision of Biochemistry, School of Medicine, Celal Bayar University School of Medicine, Manisa, Turkey; cDivision of Radiology, School of Medicine, Celal Bayar University School of Medicine, Manisa, Turkey


Background: We aimed to investigate the differences of serum leptin, gonadotropin hormones levels on GnRH stimulation test, and pelvic ultrasound (US) findings between girls with idiopathic central precocious puberty (ICPP) and premature telarche (PT). Additionally, we aimed to determine correlations between leptin and other parameters.

Method: Thirty-nine girls who had the breast budding before the age of 8 years and 19 healthy age-matched pre-pubertal girls who served as controls were included in this study. GnRH stimulation test was performed for diagnosis of ICPP to girls with breast budding. All participants underwent anthropometric and bone age assessment, and pelvic US. Basal gonadotropin and leptin levels were evaluated in all participants.

Results: No significant difference was found in leptin levels among girls with ICPP, premature telarche and prepubertal healthy peers (P>0.05). Although significant greater ovarian volumes in girls with ICPP and PT were found compared to prepubertal girls, there was no significant difference in ovarian volumes between girls with ICPP and PT. Girls with ICCP revealed a significantly greater endometrial thickness than other groups. There was positive correlation between leptin levels and body weight in all subjects. Leptin was strongly correlated with estradiol in girls with ICCP (r: 0.725, P<0.01).

Conclusion: Our results indicate that leptin level does not change in girls at the same age according to onset of puberty. In pubertal girls, leptin is correlated with estradiol level and body weight. Ovarian volume assessment is a useful examination. However, it seems not to differentiate ICPP from PT. Endometrial thickness may be useful a parameter for the diagnosis of central precocious puberty.

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