ESPE2014 Poster Category 3 Puberty and Neuroendocrinology (14 abstracts)
Characteristics of Children Treated with Leuprolide Acetate
Gulcan Seymen Karabulut a , Ayşegül Yüksel a , Elif Özsu a , Gül Yeşiltepe Mutlu b , Filiz Mine Çizmecioğlu a & Şükrü Hatun a
aPediatric Endocrinology, Kocaeli University, Kocaeli, Turkey; bZeynep Kamil Gynecologic and Pediatric Training and Research Hospital, Istanbull, Turkey
Objective: This study aims to reveal clinical, hormonal and ultrasound imaging features of patients treated with leuprolide acetate for diagnosis of precoccious puberty.
Design: Retrospective analysis of patients with a diagnosis of central precoccious puberty and treated with leuprolide acetate between January 2008 and January 2013.
Patients: 81 girls and two boys with early signs of puberty.
Results: There was a positive correlation between basal LH and peak LH/FSH values. An organic etiology was revealed in 14.8% of girl patients (hydrocephaly (7), meningomyelocele (2), hypophyseal tumor (2), rathke cleft cyst (1), and 50% of boys hamartoma (1)). The 50% of girls with organic etiology was >6 years. Majority of the patients were between 6 and 8 years old and idiopathic cases. Organic etiologies also can be seen in children older than 6 years old age, so kranial MR imaging may be indicated for selective cases >6 years old children (Table 1).
| Patient number | 83 |
| Mean age of first sign of puberty (years) | 6.66±1.87 |
| Mean age of initiation of leuprolide acetate (years) | 7.78±1.82 |
| Time to treatment (months) | 13.80±11.5 |
| Height (S.D.) | 0.96±1.39 |
| Weight (S.D.) | 1.29±1.16 |
| Midparental height | −0.82±0.95 |
| Predicted adult height | −0.86±1.46 |
| Bone age | 9.78±2.22 |
| Tanner stage at the initiation of treatment | stage 2: 6 (7.3%); stage 3: 32 (39%); stage 4: 37 (45.1%); stage 5: 7(8.5%) |
| Mean uterine length on USG (mm) | 37.02±11.07 |
| Mean ovary volüme (ml) | 2.89±2.22 |
| Mean basal LH (mIU/ml) | 1.61±1.9 |
| Mean peak LH on LHRH analog test (mIU/ml) | 12.46 (72% >5 mIU/ml) |
| Pubertal LH/FSH (>0.66) (%) | 42% |
| Mean bone age (years) | 9.78±2.22 |
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