Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 3


hrp0082p3-d1-900 | Pituitary | ESPE2014

Effect of Pubertal Status, Age and Gender on Cortisol Response to Insulin Induced Hypoglycaemia in Children and Adolescents

Giri Dinesh , Mulvey Ian Robert , Gangadharan Arundoss , Saravanai-Prabu K , Blair Jo , Dharmaraj Poonam , Das Urmi , Senniappan Senthil , Didi Mohammed

Background: There is evidence that baseline and peak cortisol response to the low dose short Synacthen test (LDSST) varies with pubertal status and gender in children with asthma on inhaled corticosteroids. There are no published data reporting effects of puberty on cortisol response to the insulin tolerance test (ITT) in childhood and adolescence.Objective and hypotheses: To determine whether pubertal status, age or gender influence basal and peak corti...

hrp0082p3-d1-901 | Pituitary | ESPE2014

Music Benefits on Postoperative Distress and Pain in Pediatric Day Care Surgery

Calcaterra Valeria , Larizza Daniela , Nakib Ghassan , Ostuni Selene , Bonomelli Irene , Mencherini Simonetta , Zambaiti Elisa , Mannarino Savina , Albertini Riccardo , Tinelli Carmine , Pelizzo Gloria

Background: Postoperative effect of music listening has not been established in pediatric age.Objective and hypotheses: The purpose of this study is to better understand the benefits of music on postoperative distress and pain in Pediatric Day Care Surgery.Methods: Forty-two children admitted for minor or intermediate surgery, were enrolled in this study. Patients were randomly assigned to the ‘music-group’ (music interve...

hrp0082p3-d1-902 | Pituitary | ESPE2014

A Case of Congenital Isolated ACTH Deficiency due to tbx19 Gene Mutation

Kazachenko Natalya , Tiulpakov Anatoly , Skorodok Yulia , Ivanov Dmitry , Mullakhmetova Zukhra

Objective: To characterise clinical presentation of congenital isolated ACTH deficiency.Methods and results: Clinical and anthropometric data were obtained. Biochemical liver function parameters, blood glucose, insulin, TSH, free thyroxin (FT4), GH, cortisol, and ACTH levels were analyzed. POMC and TBX19 genes were analysed by Sanger sequencing. The girl was born at full-term with normal weight and length. The parents are cousins. At birth cra...

hrp0082p3-d1-903 | Pituitary | ESPE2014

Xanthogranulomatous Hypophysitis: a Rare but Mistaken Pituitary Lesion

Kothandapani Jaya Sujatha Gopal , Bagga Veejay , Wharton Stephen , Sinha Saurabh , Dimitri Paul

Introduction: Xanthogranulomatous hypophysitis (XGH) is a very rare form of pituitary hypophysitis that may present both clinically and radiologically as a neoplastic lesion or craniopharyngioma. Our case series compares the paediatric and adult presentations of XGH and the differential diagnoses considered.Case series: Patient 1: A 15-year-old female presented with refractory headache, lethargy, short stature, delayed growth (weight (−3.3...

hrp0082p3-d1-904 | Pituitary | ESPE2014

Long-Term Endocrinological Follow-Up in Diencephalic Syndrome

Parpagnoli Maria , Seminara Salvatore , Anzilotti Giulia

Background: Diencephalic syndrome (DS), diencephalic cachexia or Russell syndrome, is a rare, rapidly fatal condition, usually occurring during the first year of life, as a result of a hypothalamic dysfunction due to hypothalamic/chiasmatic tumors. Clinical features of DS are weight loss leading to cachexia despite a normal caloric intake and growth rate, hyperalertness, hyperkinesis, and euphoria. Treatment is related to treatment of the hypothalamic lesion. The role of cytok...

hrp0082p3-d1-905 | Pituitary | ESPE2014

Key-Role of TSH Deficiency in Disclosing Craniopharyngioma Diagnosis in a Short Girl with Hashimoto’s Thyroiditis

Aversa Tommaso , Valenzise Mariella , Zirilli Giuseppina , Catena Mariaausilia , De Luca Filippo , Wasniewska Malgorzata

Background: Hashimoto’s thyroiditis (HT) in childhood may present with either euthyroidism (52.1% of cases), or primary overt hypothyroidism (22.2%), subclinical hypothyroidism (19.2%), overt hyperthyroidism (3.5%), or subclinical hyperthyroidism (3%). In a large series of 608 children and adolescents with presenting HT, we found in no cases a biochemical picture with low free thyroxine (FT4) and normal or low-normal TSH serum levels, i.e. a thyroid pattern tha...

hrp0082p3-d1-906 | Pituitary | ESPE2014

Pituitary Dysfunctiona with Associated Lesions in the Hypothalamo-Pituitary Region: Histiocytosis or Dysgerminoma?

Vlachopapadopoulou Elpis , Papadakis Vassilios , Nomikos Panagiotis , Michalacos Stefanos , Polychronopoulou Sophia

Background: Patients who present with clinical and laboratory findings of pituitary dysfunction and whose MRI findings reveal increased pituitary size or thickening of pituitary stalk, pose a diagnostic challenge. The differential diagnosis mainly includes dysgerminoma, histiocytosis, and hypophysitis. A non-invasive approach is often non-diagnostic.Objective and hypotheses: To present two patients with similar clinical picture and positive MRI findings,...

hrp0082p3-d1-907 | Pituitary | ESPE2014

A Case of Combined Pituitary Hormone Deficiency in a Patient Affected by Osteogenesis Imperfecta

Maines Evelina , Morandi Grazia , Ramaroli Diego , Piona Claudia Anita , Cavarzere Paolo , Gaudino Rossella , Antoniazzi Franco

Background: Combined pituitary hormone deficiency (CPHD) is a condition that causes deficiency of several hormones produced by the pituitary gland. The first signs of this condition include a failure to grow at the expected rate and short stature that usually becomes apparent in early childhood. Other features of CPHD include hypothyroidism, delayed puberty, and deficiency of the hormonal cortisol. Some conditions may exacerbate the growth failure of CPHD. Osteogenesis imperfe...

hrp0082p3-d1-908 | Pituitary | ESPE2014

Macroprolactinoma in Adolescence: a Case Report

Scott Amanda , Velayutham Valli , Campbell Robert , Cuneo Ross , Cotterill Andrew

Background: Prolactinomas are relatively rare during childhood, with an incidence of 0.1 per million. Children with hyperprolactinaemia have widely varied presentations depending on age, sex, and tumour size. Whilst adults typically present with galactorrhoea or hypogonadism, children tend to present with pubertal delay and growth issues.Objective and hypotheses: Poorer surgical outcomes have been reported in children with macroprolactinomas compared to ...

hrp0082p3-d1-909 | Pituitary | ESPE2014

Idiopathic Central Diabetes Insipidus: a Case of Pediatric Xhantogranuloma

Pozzobon Gabriella , Damia Chiara , Voto Andrea , Ferrarello Maria Piera , Garbetta Gisella , Osimani Sara , Pruccoli Giulia , Partenope Cristina , Chiumello Giuseppe

Background: Xhantogranuloma of the sellar region (XG) is a very rare brain tumor and is clinically and pathologically distinct from classical adamantinomatous craniopharyngioma, but the differential diagnosis is difficult because there are no typical neuroradiological signes. The characteristic and the outcome of XG in children remain still unclear.Objective and hypotheses: We aimed to describe a case report of XG and multiple pituitary hormone deficienc...

hrp0082p3-d1-910 | Pituitary | ESPE2014

Central Diabetes Insipidus Caused by Congenital Cytomegalovirus: a Rare Association?

dos Santos Tiago Jeronimo , Passone Caroline , Steinmetz Leandra , Cominato Louise , Kuperman Hilton , Manna Thais Della , Filho Hamilton Menezes , Dichtchekenian Vae , Pupo Joyce , Setian Nuvarte , Damiani Durval

Introduction: Central diabetes insipidus (CDI) is a condition in which large volumes of diluted urine are excreted due to vasopressin deficiency. In most patients, DI is caused by the destruction of neurons in the hypothalamus and the known causes include local inflammation or autoimmune aggression, vascular and infiltrative diseases, as well as compressive masses, trauma or midline cranial malformations. CDI caused by cytomegalovirus (CMV) infection is a very rare condition.<...

hrp0082p3-d1-911 | Pituitary | ESPE2014

Primary Polydipsia in a Family with Mutation in the AVP Gene and Proven Central Diabetes Insipidus

Casey Ruth , Hannon Anne Marie , Joyce Caroline , O'Halloran Domhnall , O'Connell Susan

Background: Diabetes insipidus (DI) is characterised clinically by the inappropriate production of large volumes of dilute urine even in the presence of clinical dehydration or deprivation of water. DI occurs either due to a deficiency or insufficiency of arginine vasopressin (AVP) hormone production. Hereditary DI accounts for <10% of the DI cases. As hyponatraemic seizures secondary to inappropriate use of desmopressin can occur, caution is required before a diagnosis of...