hrp0084p3-891 | Fat | ESPE2015

Bone Age Assessment and Glucose Metabolism in Overweight and Obese Children

Paul Corina , Mogoi Mirela , Velea Iulian

Background: Bone age (BA) tends to exceed chronological age (CA) in obese children. There are studies showing that insulin may directly influence skeletal growth. Objective: To determine whether there is an association between BA and glucose metabolism in a group of overweight and obese children.Methods: The study included 55 obese or overweight children, mean age: 11.56±3.07 years old. Anthropometric indexes (weight, height, BMI, waist circumferenc...

hrp0095p1-447 | Diabetes and Insulin | ESPE2022

Access and use of new technologies in diabetes care in patients that need an Interpreter compared to those that do not

Ayya Mekhala , Chizo Agwu Juliana

Young people with Type 1 Diabetes Mellitus encounter daily struggles with titrating insulin to achieve adequate glycemic control. Technology is improving with insulin pumps and continuous glucose monitoring (CGM) however access to it remains variable across the UK. Those from ethnic minorities and deprived areas are less likely to access technology and more susceptible to developing complications of diabetes with worsening HbA1c’s. Understanding the reasons for health in...

hrp0092p2-210 | Multisystem Endocrine Disorders | ESPE2019

Autoimmune Thyroiditis and Autoimmune Hepatitis Presenting at Onset of Type 1 Diabetes (T1D)

Marchant Alice , Chizo Agwu Juliana

Background: Autoimmune disease (AD) occurs due to loss of immunological tolerance to self-antigens and can be organ specific or systemic. One in four patients with a single AD may develop another AD. The presence of three or more AD is described as multiple autoimmune syndrome (MAS) in which Type 3 subset includes autoimmune thyroiditis and T1D, but not autoimmune hepatitis. Type 2 Autoimmune Polyendocrine Syndrome can be diagnosed when T1D and autoimmune thyr...

hrp0086p1-p363 | Gonads & DSD P1 | ESPE2016

Mosaic Xq Partial Duplication Leading to Virilisation of an Adolescent Female

Baranowski Elizabeth , Chizo Agwu Juliana

Background: We present a 17-year-old female who presented with a 1 year history of hirsutism, male pattern baldness, marked cystic acne and mild cliteromegaly. She had her menarche at the age of 15 years and continued thereon to have a regular menstrual cycle. She was pubertal on examination (B3, P5, A5) with no neurological deficit.Objective and hypotheses: This female presented with marked clinical hyperandrogenism. We initially suspected polycystic ov...

hrp0092p2-76 | Diabetes and Insulin | ESPE2019

Coexistence of Medium chain acyl-CoA dehydrogenase deficiency (MCADD) and Type 1 diabetes (T1D): A management challenge

Afreh-Mensah Donald , Agwu Juliana C.

Background: Medium chain acyl-CoA dehydrogenase deficiency (MCADD) is an autosomal recessive fatty acid β-oxidation defect. The enzyme is important in the breakdown of medium chain fats into acetyl-CoA to produce ketones, alternative energy source when glucose hepatic glycogen stores become depleted during prolonged fasting. In MCADD, during periods of fasting/ acute illness, there are insufficient ketones to compensate for the glucose energy deficit, ...

hrp0092p1-231 | Growth and Syndromes (to include Turner Syndrome) (1) | ESPE2019

Height and Weight Dynamics in Preschool Boys with Constitutional Delay of Growth and Puberty

Reinehr Thomas , Hoffmann Elisa , Rothermel Juliane , Lehrian Thersia , Binder Gerhard

Background: Constitutional delay of growth and puberty (CDGP) is one of the most frequent norm variants in children presenting with short stature. Knowing the height, growth, and weight pattern of CDGP in the first years of life is important to distinguish CDGP from growth hormone deficiency (GHD) or other diseases.Methods: We studied height and weight in the first 5 years of life in 54 boys with CDGP including measureme...

hrp0092p1-380 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

A New Model of Adult Height Prediction Validated in Boys with Constitutional Delay of Growth and Puberty

Reinehr Thomas , Hoffmann Elisa , Rothermel Juliane , Lehrian Theresia , Binder Gerhard

Background: For children with retarded bone ages such as in constitutional delay of growth and puberty (CDGP) there are no specific methods to predict adult height based on bone age. Widely used methods such as Bayley-Pinneau (BP) tend to overestimate adult height in CDGP. Therefore, we aimed to develop a specific adult height prediction model for boys in pubertal age with retarded bone age >1 year.Methods</...

hrp0084p3-936 | GH &amp; IGF | ESPE2015

Adherence to GH Treatment: Impact of Actual Height, Treatment Duration, and Puberty

Rothermel Juliane , Scheite Karl , Nazari Nadine , Hauffa Berthold , Reinehr Thomas

Background: Adherence to GH treatment is a challenge.Objective and hypotheses: We analysed the impact of treatment duration, treatment success, treatment indication, age, gender, pubertal stage, and height on treatment adherence (TA) to optimise treatment success.Method: Based on the easypod autoinjector used in the Saizen-online prospective, multicenter, open-label, noninterventional study we analyzed TA in 6 months periods. TA wa...

hrp0092p2-18 | Adrenals and HPA Axis | ESPE2019

A Rare Case of Pseudohypoaldosteronism in a Neonate Secondary to Congenital Hydrometrocolpos

Kumar Shruti , McDermott Helen , Kamupira Sheilah , Chizo Agwu Juliana

Background: Hydrometrocolpos is a condition resulting in distension of the vagina and uterus due to accumulation of secretions (other than blood), caused by increased oestrogenic stimulation and vaginal outflow obstruction. The incidence in term neonates is 0.00014-0.001%. The condition presents at extremes of childhood, at birth when maternal circulating hormones are raised and at menarche when oestrogen production commences. Pseudohypoaldosteronism (PHA)...

hrp0089p3-p345 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

The Positive Effect of the Low-Dose Contraceptive on the Course of Cystic Fibrosis in the Adolescent Female

Ferenczova Juliana , Feketeova Anna , Urbanova Veronika , Vargova Veronika

Background: In female patients with cystic fibrosis (CF), female sex predisposes to the progression and worsening of lung function, which increases the incidence of acute exacerbations, and leads to the earlier bacterial colonization of Pseudomonas aeruginosa. The negative effect of estrogens on the clinical course of CF in girls begins to manifest with the onset of puberty and the appearance of secondary sexual characteristics. On the cellular-level estrogens affect: 1.) immu...