Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 2

Puberty and Neuroendocrinology

hrp0082p2-d1-529 | Puberty and Neuroendocrinology | ESPE2014

Is There Any Influence of TSH Serum Levels on Insulin Resistance in Euthyroid Adolescents with Polycystic Ovary Syndrome?

Albu Alice , Radian Serban , Florea Suzana , Fica Simona

Background: Few previous studies suggested an association between insulin resistance (IR) and TSH serum levels in euthyroid patients. This relation could have some particularities in populations characterized by intrinsic insulin resistance like polycystic ovary syndrome (PCOS) patients.Objective and hypotheses: The aim of our study was to study the relationship between IR and TSH serum levels in adolescent euthyroid PCOS patients....

hrp0082p2-d1-530 | Puberty and Neuroendocrinology | ESPE2014

The Vaginal Maturation Index as a Marker of Local Sensitivity to Estrogens in Girls with Congenital Adrenal Hyperplasia During Puberty

Kopylova Irina , Blokh Sofya , Orlova Elizaveta , Yarovaya Irina , Kareva Maria

Background: Introital stenosis is the main complication of vaginoplasty in females with Congenital Adrenal Hyperplasia (CAH) which could result from poor estrogenization of vaginal tissue during puberty.Objective and hypotheses: To evaluate the maturation of vaginal mucosa depending on the degree of compensation.Method: 19 adolescent girls with CAH (salt-wasting (SW) – 9, simple virilizing (SV) – 10; 15.9 years (14.4, 16....

hrp0082p2-d1-531 | Puberty and Neuroendocrinology | ESPE2014

Very Low Estradiol Levels are Independent From Duration of Amenorrhea in Girls with Severe Anorexia Nervosa

Kyheng Christele , De Filippo Gianpaolo , Castell Anne-Laure , Flandrin Jennifer , Durin Julie , Delafoy Manon , Duranteau Lise

Background: Anorexia nervosa (AN) is a primary psychiatric disease, complicated by serious endocrine disturbances. Hypogonadotropic hypogonadism with primary or secondary amenorrhea is the most common endocrine repercussion of AN, with consequent estrogen deficiency and concerns about bone mineral density. Furthermore, establishing regular menstrual cycles is considered as one of the important milestones in girls treated for AN.Aim: To quantify the estro...

hrp0082p2-d1-532 | Puberty and Neuroendocrinology | ESPE2014

Evaluation of the Free Androgen Index in Adolesent Females Diagnosed with Obesity, Hirsutism, and PCOS

Sagsak Elif , Aycan Zehra , Keskin Meliksah , Erdeve Senay Savas , Cenesiz Funda , Ocal Fatma Doga , Cetinkaya Semra

Background: It is difficult to define the laboratory finding of hyperandrogenism and associate it with clinical findings in children and adolescents. Androgen levels can be high in obesity, hirsutism, and PCOS. The free androgen index (FAI) is a simple ratio used to evaluate the biologically active testosteroneObjective and hypotheses: Our aim was to determine the FAI in adolescent females and to evaluated how this index is influenced in adolescents diag...

hrp0082p2-d1-533 | Puberty and Neuroendocrinology | ESPE2014

Polycystic Ovarian Syndrome in Adolescents: Metabolic Profile at Diagnosis, During and After Treatment with Oral Contraceptive

Arcari Andrea , Gryngarten Mirta , Ballerini Maria Gabriela , Freire Analia , Rodriguez Maria Eugenia , Ropelato Maria Gabriela , Bergada Ignacio , Escobar Maria Eugenia

Background: Obesity and unfavorable metabolic profile (insulin resistance and/or dyslipidemia) are frequently observed in Polycystic Ovarian Syndrome in Adolescents (PCOS) girls regardless of weight.Objective and hypotheses: To evaluate clinical features and metabolic profile in PCOS adolescents, before, during and after Oral Contraceptive (OC) treatment.Method: We performed a retrospective study on 51 girls with PCOS diagnosed acc...

hrp0082p2-d1-534 | Puberty and Neuroendocrinology | ESPE2014

Endocrine Disruptors and Polycystic Ovary Syndrome: Phthalates

Akin Leyla , Kendirci Mustafa , Narin Figen , Kurtoglu Selim , Kondolot Meda , Saraymen Recep , Kocak Selda Ozkan , Hatipoglu Nihal , Elmali Ferhan

Background: Polycystic ovary syndrome (PCOS), characterized by hyperandrojenemia, anovulatory periods and polycystic ovaries, is a disorder in which metabolic and reproductive abnormalities overlap. The etiopathogenesis is currently unclarified. Besides the evidence of genetic causes, environmental factors are considered to be involved in development of phenotype. Phthalates are widely used industrial chemicals and have several known untoward effects on human reproductive heal...

hrp0082p2-d1-535 | Puberty and Neuroendocrinology | ESPE2014

Correlation Research of Bisphenol A and Premature Thelarche in 6 Months to 2 Years Old Infant Girls

Wu Haiying , Chen Linqi , He Guangzhao , Wang Weipeng

Background: Now in many causes of precocious puberty, thinking of environmental endocrine disruptors (EDCs) is one of the causes. Bisphenol A (BPA), as a kind of environmental endocrine disruptors, can interfere with normal endocrine activities. But up to now, there is few reports of the influence of BPA in premature thelarche (PT) of below 2 years girls.Objective and hypotheses: To investigate the association between BPA and premature thelarche in 6 mon...

hrp0082p2-d1-536 | Puberty and Neuroendocrinology | ESPE2014

Monitoring GnRH Analog Treatment in Girls with Central Precocious Puberty: a Comparison of Four Methods

Zung Amnon , Burundukov Ella , Ulman Mira , Glaser Tamar , Chen Malka , Zadik Zvi

Background: The gold standard for adequate hormonal suppression during GnRHa treatment for precocious puberty (PP) is attenuated serum LH levels in response to LHRH stimulation.Objective and hypotheses: We aimed to compare basal and post-GnRHa levels of LH to LHRH stimulation test, and to evaluate first-voided urinary LH (ULH) as a non-invasive alternative method for monitoring treatment.Method: Seventeen girls with PP were followe...

hrp0082p2-d1-537 | Puberty and Neuroendocrinology | ESPE2014

The Evaluation of Possible Role of Endocrine Disrupters in Precocious Puberty

Bulus Derya , Asci Ali , Andiran Nesibe , Kocer-Gumusel Belma , Colakoglu Elif Yagli

Background: Human health might be negatively affected by chemicals named as endocrine disrupters. Researchers showed that phthalates (bis-(2-ethylhexyl) phthalate (DEHP), mono-(2-ethylhexyl) phthalate (MEHP)) and bisphenol A (BPA) have an anti-androgenic and/or estrogenic effects. These endocrine disruptors are accused in occurrence and/or possible increase in unusual early puberty in girls in recent years.Objective and hypotheses: The aim of th...

hrp0082p2-d1-538 | Puberty and Neuroendocrinology | ESPE2014

Acute Exposure of Endocrine Disruptor does not Induce Oxidative Stress in the Rat’s Brain

Kumar Neeraj , Sharma Varsha

Background: The ever increasing uses of electronic gadgets are becoming a widespread source of Bisphenol-A accumulation. As studies have been reported that low level BPA accumulation may produce neurological effects but still limited studies have re-examined for its adverse effects in terms of acute exposure from electronic devices.Objective and hypotheses: To investigate the effects of BPA on oxidative damage in terms of activity level of antioxidant en...

hrp0082p2-d1-539 | Puberty and Neuroendocrinology | ESPE2014

Dramatic Rise in the Prevalence of Precocious Puberty in Girls Over the Past 20 Years in the South of France

Gaspari Laura , Morcrette Emilie , Jeandel Claire , Vale Fabienne Dalla , Paris Francoise , Sultan Charles

Background: Epidemiological evidence in Europe indicates the increasing prevalence of premature puberty, especially in girls. This may be attributed to in utero and early-life exposure to environmental estrogen-like compounds present in pesticides, plastics (bisphenol A, phtalates …) and beauty products.Objective and hypotheses: The aim of this study was to assess the prevalence of premature thelarche (PT) and central precocious puberty (C...

hrp0082p2-d1-540 | Puberty and Neuroendocrinology | ESPE2014

A Novel Mutation at a Splice Acceptor Site of WDR11 in a Patient with Combined Pituitary Hormone Deficiency

Izumi Yoko , Suzuki Erina , Yatsuga Shuichi , Sano Shinichiro , Nakabayashi Kazuhiko , Umezawa Akihiro , Hata Kenichiro , Ogata Tsutomu , Fukami Maki , Yoshimura Yasunori

Background: WDR11 has recently been reported as one of the causative genes of hypogonadotropic hypogonadism (HH). To date, five missense mutations in WDR11 have been identified in six patients with normosmic isolated HH (nIHH) or Kallmann syndrome (KS).Methods: We performed mutation screening of WDR11 for 46 cases with various types of HH. RT-PCR was carried out for a patient with a mutation. The protein structure of the mutant...