ESPE Abstracts (2014) 82 P-D-2-1-535

Correlation Research of Bisphenol A and Premature Thelarche in 6 Months to 2 Years Old Infant Girls

Haiying Wua, Linqi Chena, Guangzhao Heb & Weipeng Wangb

aChildren’s Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China; bCollege of Pharmaceutical Science, Suzhou University, Suzhou, Jiangsu, China

Background: Now in many causes of precocious puberty, thinking of environmental endocrine disruptors (EDCs) is one of the causes. Bisphenol A (BPA), as a kind of environmental endocrine disruptors, can interfere with normal endocrine activities. But up to now, there is few reports of the influence of BPA in premature thelarche (PT) of below 2 years girls.

Objective and hypotheses: To investigate the association between BPA and premature thelarche in 6 months to 2 years old infant girls.

Method: Forty infants aged 6 months to 2 years old with breast development and 32 female infants with no breast development as control group in our clinic from March to May 2014 were assigned in this study. Height and weight were measured and feeding condition was inquired. Serum BPA concentration was determined by HPLC–MS-MS. Sex hormones (FSH, LH, E2, and PRL) were detected by chemiluminescence method. The difference between the two groups and the correlation between BPA and sex hormones were analysed.

Results: For PT group, the BPA relevance ratio is 67.5%, and the concentration is 13.95±1.187 ng/ml, which are higher than the control group with relevance ratio 30.9%, and the concentration 8.036±0.548 ng/ml (P<0.05). The FSH and PRL concentrations have no statistical significance (P>0.05) between the two groups. The relevance ratio of E2 of PT group (50%) is higher than the control group (18.75%) (P<0.05). The relevance ratio of LH of PT group (47.5%) is higher than the control group (0.00%) (P<0.001). There are no correlations between BPA and FSH (r=0.179) and PRL (r=0.279). There are correlations between BPA and LH and E2 (P<0.05).

Conclusion: Six months to 2 years old infant girls under the existence of BPA exposure. BPA exposure is likely one of the causes of PT for 6 months to 2 years old infant girls. BPA exposure may affect the secretions of LH and E2.

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