ESPE2014 Poster Category 3 Diabetes (4) (12 abstracts)
Multiple Daily Injections Since the Diagnosis of Type 1 Diabetes Mellitus in Children and Adolescents: Assessment of 3 Years
Rita Cardoso , Dora Martins , Nanci Batista , Lina Aveiro , Rita Capitão , Helena Ribeiro , Filomena Freitas , Luisa Simão , Isabel Dinis & Alice Mirante
Coimbra Pediatric Hospital, Coimbra, Portugal
Background: Functional insulin therapy allows precise insulin adjustments to achieve normoglycaemia.
Objective and hypotheses: To assess metabolic control (A1c) and lipid profile in children and adolescents with DM1 in a 3-year period under multiple daily injections (MDI) since the diagnosis.
Method: Retrospective analysis of children and adolescents under functional insulin therapy since the diagnosis of DM1. The variables studied were: age at diagnosis, gender, pubertary stage; insulin daily dose (IDD), average blood glucose, A1c, hypo and hyperglycemias and lipid profile in the first 3 years of disease.
Results: Forty-six children and adolescents were included, 26 (56.5%) females, age at diagnosis was 8.9±3.4 years, 69.6% pre-pubescent. IDD increase significantly over the years: year 1 (0.64±0.19 U/kg per day) and year 3 (0.88±0.24; P<0.001), and average blood glucose (140.85±26.8 mg/dl vs 157.13±29.4; P<0.001). In the pre-pubertal group, there was no significant increase in the first 2 years (142.53±23.9 vs 150.9±27.2; P=0.057). A1c did not vary significantly: year 1 (7.18±0.99%) and year 3 (7.4±0.84%; P=0.139). In the pubescent group A1c increased significantly (6.86±0.93 vs 7.6±1.09; P=0.037). Hyperglycemia increased significantly: year 1 (31.9±18.1%) and year 3 (44.3±15.3%; P<0.001), without variation in hypoglycemia rate: year 1 (9.1±4.4%) and year 3 (9.1±5.8%; P=0.979). There was no significant variation of LDL cholesterol and triglycerides (2.1±0.57 vs 2.2±0.57 mmol/l; P=0.41–0.71±0.29 vs 0.80±0.37 mmol/l; P=0.113).
Conclusion: Functional insulin therapy contributes to good metabolic control with low frequency of hypoglycemia, even in pre-pubertal children. Therapeutic education is needed on how to adjust insulin to avoid hyperglycemia increasing. This therapy is safe since the diagnosis of DM1.
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more