ESPE2015 Poster Category 2 Diabetes (60 abstracts)
Circulating GLP-1 in Infants Born Small-for-Gestational-Age: Breast-Feeding Vs Formula-Feeding
Marta Díaz a, , Judit Bassols c , Giorgia Sebastiani a, , Abel López-Bermejo c , Lourdes Ibáñez a, & Francis de Zegher d
aUniversity of Barcelona, Hospital Sant Joan de Déu, Barcelona, Spain; bCIBERDEM, Madrid, Spain; cHospital Dr Josep Trueta & IDIBGI, Girona, Spain; dUniversity of Leuven, Leuven, Belgium
Background: Prenatal growth restraint associates with risk for later diabetes particularly if such restraint is followed by postnatal formula-feeding (FOF) rather than breast-feeding (BRF). Circulating incretins can influence the neonatal programming of hypothalamic setpoints for appetite and energy expenditure, and are thus candidate mediators of the long-term effects exerted by early nutrition.
Objective, hypotheses and method: We have tested this concept by measuring (at birth and age 4 months) the circulating concentrations of glucagon-like peptide-1 (GLP-1) in BRF infants born appropriate-for-gestational-age (AGA; N=63) and in small-for-gestational-age (SGA) infants receiving either BRF (N=28) or FOF (N=26).
Results: At birth, concentrations of GLP-1 were similar in AGA and SGA infants. At 4 months, pre-feeding GLP-1 concentrations were higher than at birth; SGA-BRF infants had GLP-1 concentrations similar to those in AGA-BRF infants but SGA-FOF infants had higher concentrations.
Conclusion: Nutrition appears to influence the circulating GLP-1 concentrations in SGA infants and may thereby modulate long-term diabetes risk.
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