ESPE Abstracts (2015) 84 P-2-381

Metformin in Combination with Lifestyle Changes Effectively Reduces BMI and Waist Circumference in Overweight/Obese Children and Adolescents

Natalija Smetaninaa, Adrone Seibokaitea, Raimondas Valickasb, Gintaras Kuprionisb, Jolanta Janina Grigonienee, Ruta Rokaited, Astra Vitkauskienec, Kerstin Albertsson-Wiklandf & Rasa Verkauskienea


aInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; bDepartment of Radiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; cDepartment of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; dDepartment of Pediatrics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; eLithuanian Sports University, Kaunas, Lithuania; fGP-GRC, Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden


Background: Overweight (OW) and obesity in paediatric population has been shown to be associated with an increase in prevalence of insulin resistance and type 2 diabetes (T2D) in youth.

Objective and hypotheses: The aim of this study was to assess the efficiency and safety of metformin use in combination with lifestyle changes or alone for weight management in OW and obese (OB) children and adolescents.

Methods: Study included 145 10–17 years old OW (BMI 1.0–2.0 S.D.) and OB (BMI ≥2.0 S.D.) children and adolescents of age. Study participants were randomised into four groups: group 1 – controls (n=33), group 2 – lifestyle changes with two-times weekly swimming pool exercise and monthly dietologist consultations (n=26), group 3 – metformin treatment (n=21), and group 4 – metformin treatment in combination with lifestyle changes (n=32). Anthropometric parameters were evaluated in all study subjects at baseline and after 12 months of intervention.

Results: Mean age of study participants was 13.4±2.0 years; 44.1% were boys; 32.6% were OW, others – OB. Reduce in BMI, waist circumference (WC), and WC–SDS adjusted by gender and puberty stages was significantly greater in the group 4 compared to the group 1 (Δ −1.07±2.8 kg/m2 vs Δ 0.18±2.1 kg/m2, P=0.029; Δ −4.5±5.7 cm vs Δ −1.8±5.2 cm, P=0.04, and Δ −0.85±0.8 vs Δ −0.38±0.7, P=0.009 respectively). Changes in these parameters in other groups compared to group 1 were not significant. Initially, mild side effects of metformin (nausea and diarrhoea) were observed in 21.6% of subjects from groups 3 to 4, which disappeared within 1 week of metformin administration.

Conclusion: Twelve months metformin treatment with lifestyle modification was effective and safe method reducing BMI and waist circumference in OW/OB children and adolescents, superior to that of lifestyle changes alone.

Funding: Lithuanian Research Council (grant number MIP-039/2013), grant from Research Foundation of Lithuanian University of Health Sciences (2013).