Background/objective and hypotheses: Chest circumference (CC) is related to intrauterine growth rate as well as to development-function of respiratory system. We evaluated the relevance of birth body weight (BW) in birth CC (BC) relations to blood serum IGF1 after control for preterm birth (PTB), oxygen (O2) supplementation as %O2 in respiratory gases (O2R) and assisted ventilation of any kind (AV) in the newborn (NWB) without life-threatening disease.
Method: Data available in each NWB: i) gender (SEX), gestational age (GA, unit:complete week), BW (unit:gr), BC (unit:cm), presence/absence of BW<10th centile for GA (SGA) or of PTB defined as GA≤36, and ii) same-day records of AV, O2R, and IG1 RIA-measurements (unit:μM/dl) at one of the first 5 postnatal days (x), 5 days after x(y) and 10 days after x(z), of postnatal age (PNA;unit:day). NWBs with any among total parenteral nutrition, life-threatening disease, diabetes mellitus (DM), endocrine diagnosis out of DM, clinically relevant trunk trauma or DM in mother were excluded. 78 NWBs were included (male SEX,n,43; PTB,n,46; SGA,n,20; GA range=2842; BW range=12004150; BC range=22.039.0; presence of O2R,n,x=22,y=11,z=1; presence of AV,n,x=8,y=4,z=1). Natural log-transformed IGF1 (IGF1-LN) resulted near-normally distributed. Multiple Linear Regression (MLR) was used (computations; male SEX, PTB, AV, condition present=1, condition absent=0).
Results: MLRs with IGF1-LN as outcome showed a significant partial correlation (PC) coefficient (r) of BC PCs with IGF1-LN when including as predictors PNA, O2R and AV chronologically corresponding to outcome, as well as SEX, PTB and BC (BC vs IGF1-LNx, r:0.37, P: 0.0012; BC vs IGF1-LNy, r: 0.40, P: 0.0005; BC vs IGF1-LNz, r: 0.29, P: 0.0142), while no significant r of BC PCs with IGF1-LN at x, y or z was observed in MLRs including i) IGF1-LN as outcome and ii), as predictors, PNA, O2R and AV chronologically corresponding to outcome as well as SEX, PTB, BC and BW (R2 of MLR models, 0.270.54, significant in all cases).
Conclusion: BW could be involved in BC relations to IGF1-LN not explained by SEX, PTB, PNA, O2R and AV in not-life-threatened NWBs.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology