Background/objective and hypotheses: Chest circumference (CC) is related to intrauterine growth rate as well as to development-function of respiratory system. We evaluated the relevance of birth body weight (BW) and blood serum IGF1 (IG1) in birth CC (BC) relations to blood serum IGF-binding-protein-3 (IB3) after control for preterm birth (PTB), oxigen (O2) supplementation as %O2 in respiratory gases (O2R) and assisted ventilation of any kind (AV) in the newborn (NWB) without life-threatening disease.
Method: Data available in each NWB: i) gender (SEX), gestational age (GA, unit:complete week), BW (unit:gr), BC (unit:cm), BW<10th centile for GA (SGA), PTB defined as GA≤36 and, ii) same-day records of postnatal age (PNA;unit:day), O2R, AV and IG1-IB3 RIA measurements (unit:μM/dl) at one of the first 5 postnatal days(x), 5 days after x(y) and 10 days after x(z). 78 NWBs without any among total parenteral nutrition, life-threatening disease, diabetes mellitus (DM), endocrine diagnosis out of DM, malformation, clinically relevant trunk trauma or DM in mother were included (male SEX,n,43; SGA,n,20; GA range=2842; BW range=12004150;BC range=22.039.0;PTB,n,46; presence of O2R,n,x=22,y=11,z=1; presence of AV,n,x=8,y=4,z=1). Natural log-transformed IB3 (IB3-LN) resulted near-normally distributed. Multiple Linear Regression (MLR) was used (computations; male SEX, PTB, AV, condition present=1, condition absent=0).
Results: MLRs with IB3-LN as outcome showed a significant partial correlation (PC) coefficient (r) of BC PCs with IB3-LN when including as predictors either i) PNA, O2R and AV chronologically corresponding to outcome, and SEX, PTB and BC (BC vs. IB3-LNx, r=0.35, P=0.0022; BC vs IB3-LNy, r=0.47; P=0.0000; BC vs IB3-LNz, r=0.53, P=0.0000), or 2)PNA, O2R, AV and IG1 chronologically corresponding to outcome and SEX, PTB and BC (BC vs. IB3-LNx, r=0.30; P=0.0101;BC vs. IB3-LNy, r=0.30; P=0.0104;BC vs. IB3-LNz, r=0.51; P=0.0000), while MLRs showed no significant r of BC PCs with outcome IB3-LN at x, y or z when including as predictors PNA, O2R and AV chronologically corresponding to outcome, as well as SEX, PTB, BC and BW (R2 of MLR models, 0.38-0.66, significant in all cases).
Conclusion: BW appeared more able than IG1 chronologically corresponding to IB3-LN in explaining BC relations to IB3-LN after control for SEX, PTB, PNA, O2R and AV in not-life-threatened NWBs.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology