Background: Cohort SGA in North of Spain EPIPEG.
Objective and hypotheses: Establish a SGA cohort for monitoring, assessment catch-up, and analysis of middle-environmental and social factors.
Method: We study live births in singleton pregnancies in our hospital during 20122014, and are classified according age gestation (EG) and weight/height (Spanish growth 2008). Visits were made at 0, 3, 6, 9, 12 months, with measurements weight, height and perimeter. Blood samples are analyzed and be stored is obtained.
Results: 80 PEG recruited in 18 months (♂44, 55%). Epidemiological data: average age 32.2 years mother brothers previous SGA 11/80 (14%); maternal smoking during pregnancy 32/80 (40%), 4 (315) cigarettes/day; worker during pregnancy 55/80 (68%), of which 80% with >3 h walking/day; drugs during pregnancy 24/80 (30%), 70% for asthma, 20% L-thyroxine and 10% other. Pathologies associated: 41/80 (53%) (gestosis, eclampsia, DM, thyroiditis, psychogenic stress). Childbirth: a term 52/80 (67%), eutocic 68/80 (85%). Facts children at birth: middle weight DS −2.6 (−3.5 to 2.0), average size DS −2.5 (−3.2 to 2.1), for sex and EG. Lactation exclusive breast: 60/80 (75%) during the 1st month of life. RN income or pathology in the 1st month of life 20/80 (25%). PEG cases that have reached 12 months of follow up 48 cases. Income over 12 months 2/48 (4%) (bronchitis). With 12 months of life have 7/48 cases (15%) did not catch up with adequate P and/or T <P10, 28/48 cases (60%) catch up very fast with P and/or T> P90.
Conclusion: The age of the pregnant, their lifestyle (snuff, stress and work) and regular medications (asthma), is causing of SGA. These children seem to require greater use of artificial feeding, a higher rate of hospital admissions at birth than children with PAG, but later is not a disease risk population. However detected since 75% of the RN SGA present a metric inappropriate development with year of life, which may have future implications.
Funding: Pfizer international research grants were used for starting this study and for buying clinical material and a personal computer.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology